Neuropore Therapies is a California-based drug discovery company dedicated to halting the progression of neurodegenerative diseases by targeting the core processes that underlie these disorders. Neuropore uses handheld pipettes from INTEGRA to accelerate research in both in vivo and in vitro pharmacology departments.
Neuropore Therapies have supported INTEGRA for a long time, starting with the first generation of VOYAGER adjustable tip-spacing pipettes, EVOLVE manual pipettes and VIAFLO electronic pipettes, and continuing through successive generations of products.
“We have been using INTEGRA pipettes in our R&D activities for a number of years,” said a scientist at the company. “We initially started with just the VIAFLO electronic multichannel pipettes. As our biochemical and cell-based assay capabilities expanded, we needed a versatile solution that would allow us to reformat among the different volume and plate requirements of each workflow.”
Easy Sample Reformatting
VOYAGER pipettes are perfect for sample formatting between different labware because, depending on configuration, tip spacing can adjust automatically between 4.5 and 33 mm at the push of a button.
“Our cell cultures are grown in 24, 48 or 96 well plates to ensure that we generate enough material to perform biochemical assays, but we then assess the cells in a 384 well format. We therefore needed a system that would allow us to quickly and easily reformat samples from their culture environment to the assay plate. The automatically adjustable tip spacing offered by the VOYAGER electronic pipette was ideal. We initially had only one VOYAGER from each volume range, but quickly purchased more; now we have several of each size and configuration, shared between the two departments.”
Smaller is Better
Similarly to many other drug discovery laboratories worldwide, Neuropore is interested in assay miniaturization as a way of reducing the cost of experiment sand increasing throughput.
“Scaling down assays allows you to test more parameters per experiment. This saves time, space and consumables, helping to reduce the overall cost per test. Increasing our throughput and expanding our high content screening activities, without sacrificing data quality, required the ability to quickly and accurately pipette multiple low volume samples into 384 well plates. Our VIAFLO and VOYAGER electronic multichannel pipettes provide the necessary precision, while reducing errors associated with large numbers of individual samples, giving us complete confidence in our results.”
Simplifying Day-to-Day Activities
The GripTip pipette tip system that is used for all INTEGRA pipettes means that the tips are perfectly aligned, never leak, and are always firmly attached, while still being easy to pick up and eject.
“We have also recently purchased a number of EVOLVE manual pipettes, as having one set of tips at the bench to satisfy all our pipetting needs makes life easier. The ergonomics of the three dial system on the EVOLVE makes it much faster to adjust between high and low volumes, which has sped up a lot of our single channel pipetting activities. It’s a win-win situation.”
About INTEGRA Biosciences
INTEGRA provides innovative solutions for Liquid Handling and Media Preparation applications which serve the needs of their customers in research, diagnostics and quality control laboratories.
Their instruments and plastic consumables are developed and manufactured in Zizers, Switzerland and Hudson, NH USA. In order to remain close to their customers, they maintain a direct sales and support organization in North America, the UK, France and Germany, as well as a network of over 100 highly trained distribution partners worldwide.
In recent years they have focused on developing a new and technologically advanced range of handheld electronic pipettes which are simple to use and meet the ergonomic needs of their customers. Today they are proud to offer the widest range of electronic pipettes in the market spanning a range from single channel pipettes up to 384 channel bench-top instruments.
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