Poly(lactide-co-glycolide) copolymers (PLGAs) are biodegradable, biocompatible synthetic materials widely used across pharmaceutical applications. Derived from lactic and glycolic acids, these copolymers break down into non-toxic metabolites, making them particularly well-suited for drug delivery systems and resorbable implants.
One of PLGA's key advantages lies in the precise control over composition and microstructure during manufacturing, allowing their properties to be finely tuned for specific therapeutic needs. However, the broad diversity of PLGA-based materials also presents challenges in ensuring consistent quality. Variability in polymer structure can directly impact performance and safety, making reliable characterization essential.
Despite their established use in many approved drug products, PLGAs have only recently been included in major pharmacopeias, and even then, only a limited number of variants are covered.
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