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Codon frequency optimization shows SARS-CoV-2 antiviral potential

A study conducted by researchers in the US has revealed that optimization of codon for bacterial expression causes the production of an inactive enzyme non-structural protein 12 (Nsp12), a catalytic subunit of RNA-dependent RNA polymerase of SARS-CoV-2.

26 Jan 2021

New partnership to develop test for predicting disease course in pediatric Crohn's patients

The Crohn's & Colitis Foundation, the leading non-profit organization focused on both research and patient support for inflammatory bowel disease (IBD), has entered into a partnership with LifeArc, an independent medical research charity that advances translation of early science into health care treatments or diagnostics, to potentially develop the first clinical lab test to predict disease course in pediatric patients with Crohn's disease and response to treatment.

25 Jan 2021

Researchers update automated computation tool for SARS-CoV-2 genome analysis

Researchers updated a previous version of an automated tool to include SARS-CoV-2 genome analysis. Genome analysis using the freely available software could help track the evolution of the virus and promptly identify variants that increase viral transmission or virulence.

22 Jan 2021

The structure dynamics of the SARS-CoV-2 genome in cells, cell lysates and virions

Now, a new preprint research paper posted to the bioRxiv server describes the structures observed during the lifecycle of the RNA virus in terms of both canonical and alternative structures, RNA-RNA interactions, and replication regulation.

19 Jan 2021

New SARS-CoV-2 variant emerges in the U.S.

Even as the rollout of vaccines all over the world brings a glimmer of hope that the current coronavirus disease 2019 (COVID-19) pandemic may end in the near future, new variants continue to emerge, some with the potential to escape vaccine-induced or therapeutic antibodies. Now, a new preprint research paper published on the bioRxiv server describes a new American variant that may have become the dominant strain in the USA.

18 Jan 2021

Stem cells with regenerative abilities could be closer on the horizon, shows study

A new type of stem cell - that is, a cell with regenerative abilities - could be closer on the horizon, a new study led by UNSW Sydney shows.

14 Jan 2021

New tests may help reveal the transcriptome of SARS-CoV-2 and predict disease course

As the COVID-19 pandemic continues to infect people in their hundreds of thousands around the world, a new study describes a panel of novel tests for genomic (g) and subgenomic (sg) mRNAs generated by SARS-CoV-2. Most assays in use at present are either qualitative or semi-quantitative, and cannot evaluate the transcription molecules in detail.

14 Jan 2021

Scientists discover genetic variations that have a drastic impact on small molecules

The human organism requires a variety of small molecules, such as sugars or fats, in order to function properly.

14 Jan 2021

Researchers receive $5.1 million to expand clinical trial of drug to prevent ARDS in COVID-19 patients

Researchers evaluating whether an investigational oral drug, vadadustat, can help prevent acute respiratory distress s to expand the Phase II clinical trial at The University of Texas Health Science Center at HoustonQ.

13 Jan 2021

New deep-learning framework predicts gene regulation at single-cell level

Scientists at the University of California, Irvine have developed a new deep-learning framework that predicts gene regulation at the single-cell level.

13 Jan 2021

Study: 82% respondents ventilate more frequently to protect themselves from corona

Despite cold temperatures, the population counts on fresh air to avoid contracting the coronavirus. This is shown by the results of the 26th edition of the BfR-Corona-Monitor, a regular survey by the German Federal Institute for Risk Assessment (BfR). In all age groups, about four out of five respondents say they ventilate more frequently.

13 Jan 2021

Patient with hypertension or cardiovascular diseases experienced critical disease progression with COVID-19

COVID-19 patients who also suffer from high blood pressure are more likely to fall severely ill with the disease, which also leaves them at greater risk of death.

11 Jan 2021

Nuclear DICER complex disrupts cytoplasmic microRNAome in glioblastoma cancer cells

Like Peter Pan, some cells never grow up. In cancer, undifferentiated stem cells may help tumors such as glioblastoma become more aggressive than other forms of the disease.

8 Jan 2021

Study examines the impact of COVID-19 pandemic on dental students' career plans

The COVID-19 pandemic has significantly impacted dental education and training. The study "COVID-19 and Dental and Dental Hygiene Students' Career Plans," published in the JDR Clinical & Translational Research (JDR CTR), examined the short-term impact of the COVID-19 pandemic on dental hygiene and dental students' career intentions.

7 Jan 2021

Proteogenomics can help determine effective treatment for head and neck squamous cell carcinoma

Proteogenomic analysis may offer new insight into matching cancer patients with an effective therapy for their particular cancer.

7 Jan 2021

International consortium awarded SNSF Sinergia grant to improve treatment for pediatric brain tumors

SNSF Sinergia grant awarded to research groups in Switzerland and Norway to identify novel treatment strategies for children with aggressive brain tumors.

7 Jan 2021

Researchers provide comprehensive molecular characterization of head and neck cancers

In what is believed to be the most comprehensive molecular characterization to date of the most common type of head and neck cancer, researchers from the Johns Hopkins departments of pathology and oncology, the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine, and 18 other centers around the U.S. and Poland have clarified the contribution of key cancer-associated genes, proteins and signaling pathways in these cancers, while proposing possible new treatment avenues.

7 Jan 2021

MD Anderson and Xencor to develop novel antibody therapeutics to treat cancer patients

The University of Texas MD Anderson Cancer Center and Xencor, Inc. today announced a strategic research collaboration and commercialization agreement to develop novel CD3 bispecific antibody therapeutics for the potential treatment of patients with cancer.

7 Jan 2021

Mount Sinai and Rumi Scientific join hands to initiate autism drug discovery pipeline

The Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai and Rumi Scientific announced today that they will team up to initiate a drug discovery pipeline for rare genetic disorders that carry a high risk of autism.

6 Jan 2021

Researchers develop detailed map of protein-protein interactions between SARS-CoV-2 and the host

By conducting a state-of-the-art interactome study between SARS-CoV-2 and host cells, researchers from the University of Texas MD Anderson Cancer Center in Houston identified 437 human proteins as the high-confidence interacting proteins – with substantial implications for understanding coronavirus disease 2019 (COVID-19) pathology and potential treatments.

5 Jan 2021

Translation News and Research

Codon frequency optimization shows SARS-CoV-2 antiviral potential

New partnership to develop test for predicting disease course in pediatric Crohn's patients

Researchers update automated computation tool for SARS-CoV-2 genome analysis

The structure dynamics of the SARS-CoV-2 genome in cells, cell lysates and virions

New SARS-CoV-2 variant emerges in the U.S.

Stem cells with regenerative abilities could be closer on the horizon, shows study

New tests may help reveal the transcriptome of SARS-CoV-2 and predict disease course

Scientists discover genetic variations that have a drastic impact on small molecules

Researchers receive $5.1 million to expand clinical trial of drug to prevent ARDS in COVID-19 patients

New deep-learning framework predicts gene regulation at single-cell level

Study: 82% respondents ventilate more frequently to protect themselves from corona

Patient with hypertension or cardiovascular diseases experienced critical disease progression with COVID-19

Nuclear DICER complex disrupts cytoplasmic microRNAome in glioblastoma cancer cells

Study examines the impact of COVID-19 pandemic on dental students' career plans

Proteogenomics can help determine effective treatment for head and neck squamous cell carcinoma

International consortium awarded SNSF Sinergia grant to improve treatment for pediatric brain tumors

Researchers provide comprehensive molecular characterization of head and neck cancers

MD Anderson and Xencor to develop novel antibody therapeutics to treat cancer patients

Mount Sinai and Rumi Scientific join hands to initiate autism drug discovery pipeline

Researchers develop detailed map of protein-protein interactions between SARS-CoV-2 and the host

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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