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Disrupting protein quality control slows tumor growth in pediatric rhabdomyosarcoma

A new research paper was published in Volume 16 of Oncotarget on August 29, 2025, titled "In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma."

29 Aug 2025

Predictable music phrases found to regulate blood pressure

A new study has found that blood pressure synchronises to predictable phrase structures in music. Blood pressure was more affected by loudness than tempo and was more strongly influenced by phrase structures that were more predictable.

29 Aug 2025

How do common painkillers drive stronger E. coli resistance?

Research shows that non-antibiotic medications like ibuprofen can enhance E. coli mutations, raising concerns about antimicrobial resistance in older adults.

29 Aug 2025

First clinical trial in cats tests targeted therapy for deadly head and neck cancer

Researchers have reported results from the first-ever clinical trial of a new class of targeted therapy in pet cats with head and neck squamous cell carcinoma (HNSCC)-a cancer which is notoriously deadly and difficult to treat.

28 Aug 2025

Evidence-based calculator to guide hypertension treatment choices

A first-of-its-kind Blood Pressure Treatment Efficacy Calculator built on data from nearly 500 randomized clinical trials in over 100,000 people allows doctors to see by how much different medications are likely to lower blood pressure.

28 Aug 2025

Study brings hope for a more personalized approach to treat ER+ breast cancer

A new study from researchers at Baylor College of Medicine brings hope for a more personalized approach to treat estrogen receptor-positive (ER+) breast cancer, the most common type of this cancer.

28 Aug 2025

New advances offer hope in the fight against KRAS-driven pancreatic cancer

Accounting for nearly 90% of all pancreatic cancers, pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of just 13%. Late-stage diagnosis, limited surgical options, and toxic chemotherapy regimens contribute to its poor outcomes.

28 Aug 2025

Researchers develop novel exosome-based therapeutic agent for treating traumatic CNS injuries

Traumatic injuries of the central nervous system (CNS)-such as traumatic brain injury (TBI) and traumatic spinal cord injury (SCI)-are characterized by oxidative damage and neuroinflammation.

28 Aug 2025

New global consensus offers hope for women with inflammatory bowel disease during pregnancy

For women with inflammatory bowel disease (IBD), pregnancy can be an uncertain time due to limited clinical data about how IBD medications impact pregnancy outcomes and infants who have been exposed to IBD medications in utero.

28 Aug 2025

Alcohol misuse among college students linked to academic and mental health harms

It's well known that alcohol misuse can harm not only drinkers themselves but also those around them. Now, a new report in the Journal of Studies on Alcohol and Drugs shows that, among college students, harms such as lower grades, mental distress and even suicidal thoughts are linked to being exposed to a drinker's poor behavior.

28 Aug 2025

Probiotic enhances cholesterol drug efficacy but raises safety concerns at high doses

A recent study published in Engineering has shed light on the complex interactions between probiotics and drugs, particularly focusing on the effects of the probiotic Lacticaseibacillus paracasei Zhang (LCZ) on the cholesterol-lowering drug lovastatin.

28 Aug 2025

New swallowable device enables noninvasive gut nerve stimulation

Scientists have long struggled with how to study the gut's vast nervous system - often called the body's 'second brain' - without damaging it.

28 Aug 2025

Chronic neuron overactivation may drive Parkinson's disease progression

Certain brain cells are responsible for coordinating smooth, controlled movements of the body. But when those cells are constantly overactivated for weeks on end, they degenerate and ultimately die.

28 Aug 2025

Gut mast cells produce key molecules driving food allergy anaphylaxis

Food allergies affect more than half a billion people worldwide. In severe cases, even a small bite of the wrong food can trigger anaphylaxis - a rapid, body-wide allergic reaction that can cause difficulty breathing, a dangerous drop in blood pressure and even death.

28 Aug 2025

Certain dietary fats found to trigger hard-to-treat asthma in children

Researchers at Children's Hospital of Philadelphia (CHOP) found that certain lipids, or fats, in obesity-causing foods also cause asthma-like lung inflammation.

27 Aug 2025

Increasing numbers of bariatric surgery patients turn to GLP-1 drugs

Bariatric surgery is usually effective on its own for weight loss, but an increasing proportion of patients who undergo bariatric surgery start taking one of the new glucagon-like 1 peptide receptor agonist (GLP-1) weight-loss drugs in the years after their surgery, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

27 Aug 2025

Regenerative strategy offers hope for women with pelvic organ prolapse

Pelvic organ prolapse (POP) is a disorder that primarily affects older women who have experienced multiple vaginal childbirths.

27 Aug 2025

Why Salmonella Dublin poses a food safety threat in beef and dairy

The study on Salmonella Dublin highlights its genomic similarities and resistance traits, raising concerns for food safety and antimicrobial resistance.

27 Aug 2025

Targeting gut signaling protein may protect against alcohol-related liver damage

Alcohol-associated liver disease (ALD) is a major cause of liver transplantation and death worldwide, and its impact is only growing. In 2022, the annual cost of ALD in the United States was $31 billion.

27 Aug 2025

Adjusting fertility drug timing boosts ovulation success in rat models

Researchers at Osaka Metropolitan University have found that changing the timing of fertility drugs to match the follicle maturity period significantly increases the number of ovulated oocytes-the cells that develop into eggs-during artificial fertilization, even in rats that typically produce few oocytes.

27 Aug 2025