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Researchers identify subtypes of retinal ganglion cells using single-cell RNA sequencing

Single-cell sequencing technologies are filling in fine details in the catalog of life. Researchers at the University of Connecticut Health Center and The Jackson Laboratory have identified 40 subtypes of retinal ganglion cells along with the genetic markers and transcription factors that differentiate them.

19 Jul 2018

Advanced MRI technique predicts risk of disease progression in MS

An advanced MRI technique could help to identify patients with MS who are at an increased risk of developing a physical disability.

17 Jul 2018

Study findings highlight importance of early detection of SMA through newborn screening

Spinal muscular atrophy is a genetic disease that affects motor neurons in the spinal cord, resulting in muscle atrophy and widespread weakness that eventually impair swallowing and breathing.

17 Jul 2018

Study highlights potential of fetal gene therapy to prevent lethal neurodegenerative disease

A fatal neurodegenerative condition known as Gaucher disease can be prevented in mice following fetal gene therapy, finds a new study led by UCL, the KK Women's and Children's Hospital and National University Health System in Singapore.

16 Jul 2018

UW-Madison researchers develop new method to track Parkinson's damage in the heart

A new way to examine stress and inflammation in the heart will help Parkinson's researchers test new therapies and explore an unappreciated way the disease puts people at risk of falls and hospitalization.

13 Jul 2018

Immunotherapies may increase overall survival in patients with melanoma brain metastases

Among patients with cutaneous melanoma who had brain metastases (MBM), first-line treatment with a checkpoint inhibitor was associated with a 1.4-fold increase in median overall survival, according to results from a national cohort.

13 Jul 2018

Sodium nitroprusside treatment prevents schizophrenia symptoms in animal model

Researchers at the Federal University of São Paulo in Brazil have tested a treatment with sodium nitroprusside in a strain of rats that spontaneously develop some of the symptoms associated with schizophrenia.

12 Jul 2018

FDA requires safety labeling changes for fluoroquinolones to strengthen warnings on adverse reactions

The U.S. Food and Drug Administration today is requiring safety labeling changes for a class of antibiotics called fluoroquinolones to strengthen the warnings about the risks of mental health side effects and serious blood sugar disturbances, and make these warnings more consistent across the labeling for all fluoroquinolones taken by mouth or given by injection.

11 Jul 2018

Study explores occurrence and treatment of brain metastases in ROS1 lung cancer

Increasingly, doctors are treating lung cancer based on the genetic rearrangements driving the disease. For example, cancers that are driven by changes in the genes ALK, EGFR, and ROS1 can now all be paired with drugs that target these specific changes.

10 Jul 2018

Fluorescent fish could help find origins of neuroblastoma

A new type of zebrafish that produces fluorescent tags in migratory embryonic nerve precursor cells could help a Rice University neurobiologist and cancer researcher find the origins of the third-most common pediatric cancer in the U.S.

10 Jul 2018

Researchers identify genes associated with aggressive behavior

Researchers from the University of Barcelona and collaborators have pin-pointed forty genes that are associated with aggressive behaviors in humans and in mice.

9 Jul 2018

Scientists synthesize new compound with anticarcinogenic properties

The patent has been registered from the University of Seville and licensed by the British company Evgen Pharma, which is currently developing programmes aimed at breast cancer, subarachnoid haemorrhage and multiple sclerosis, among others

5 Jul 2018

Scoring system based on PIRO helps predict mortality in surgical ICU patients with severe sepsis

A new classification system that scores the variables associated with mortality rates for patients who develop intra-abdominal sepsis after surgery may help guide care and improve outcomes

2 Jul 2018

New molecular imaging method could help effectively tackle brain conditions

A new molecular imaging method can monitor the success of gene therapy in all areas of the brain, potentially allowing physicians to more effectively tackle brain conditions such as Parkinson's disease, Alzheimer's disease and multiple sclerosis.

26 Jun 2018

UVA research shows true nature of immune cells blamed in Alzheimer's

Immune cells commonly blamed in Alzheimer's and other neurodegenerative diseases are actually precision cleaning machines protecting the central nervous system, new research from the University of Virginia School of Medicine shows.

26 Jun 2018

CRISPR technique reduces repetitive behavior in fragile X syndrome mouse models

Scientists have used CRISPR-Cas9 gene editing to lessen some autism symptoms in mice with a form of fragile X syndrome, the most common known single-gene cause of autism spectrum disorder.

25 Jun 2018

Scientists identify immune cells that remove degenerating neurons after brain injury

Researchers have identified the immune cells that are responsible for clearing dead and dying nerve cells following a brain injury.

25 Jun 2018

Researchers use gene editing to reduce autism symptoms in mice

Researchers have used CRISPR-Cas9 gene editing to treat symptoms of autism in mice. It is hoped that the tool could one day be used to help humans.

25 Jun 2018

Studying The Effects of Microgravity on Muscle Mass

Studying the effects of gravity on muscle cells can give us an insight into muscle wastage diseases, and potentially guide the development of new therapies. Professor Louis Yuge discusses his research and the cellular changes that occur in response to microgravity.

25 Jun 2018

UC Riverside researcher receives grants to advance cancer, ALS research

Maurizio Pellecchia, who holds the Daniel Hays Chair in Cancer Research at the University of California, Riverside, has received two grants to continue his research aimed at finding therapeutics for cancer, amyotrophic lateral sclerosis, and other neurodegenerative diseases.

21 Jun 2018

Central Nervous System News and Research

Researchers identify subtypes of retinal ganglion cells using single-cell RNA sequencing

Advanced MRI technique predicts risk of disease progression in MS

Study findings highlight importance of early detection of SMA through newborn screening

Study highlights potential of fetal gene therapy to prevent lethal neurodegenerative disease

UW-Madison researchers develop new method to track Parkinson's damage in the heart

Immunotherapies may increase overall survival in patients with melanoma brain metastases

Sodium nitroprusside treatment prevents schizophrenia symptoms in animal model

FDA requires safety labeling changes for fluoroquinolones to strengthen warnings on adverse reactions

Study explores occurrence and treatment of brain metastases in ROS1 lung cancer

Fluorescent fish could help find origins of neuroblastoma

Researchers identify genes associated with aggressive behavior

Scientists synthesize new compound with anticarcinogenic properties

Scoring system based on PIRO helps predict mortality in surgical ICU patients with severe sepsis

New molecular imaging method could help effectively tackle brain conditions

UVA research shows true nature of immune cells blamed in Alzheimer's

CRISPR technique reduces repetitive behavior in fragile X syndrome mouse models

Scientists identify immune cells that remove degenerating neurons after brain injury

Researchers use gene editing to reduce autism symptoms in mice

Studying The Effects of Microgravity on Muscle Mass

UC Riverside researcher receives grants to advance cancer, ALS research

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