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Researchers identify chemical signals that promote breast cancer metastasis

Working with mice, Johns Hopkins researchers report they have identified chemical signals that certain breast cancers use to recruit two types of normal cells needed for the cancers' spread.

23 May 2014

Erlotinib, gefitinib have similar efficacy in NSCLC patients with EGFR mutation

Disease progression-free survival is similar for patients with non-small-cell lung cancer and epidermal growth factor receptor mutations whether they receive erlotinib or gefitinib, show the results of a South Korean study.

21 May 2014

IL-8 expression predicts lung adenocarcinoma prognosis

Interleukin -8 expression is associated with a poor lung adenocarcinoma prognosis, say Japanese researchers, especially in patients whose tumours are positive for the KRAS mutation.

19 May 2014

FibroGen’s Phase 2a study supports safety and efficacy of FG-3019 in IPF patients

FibroGen, Inc. (FibroGen) announced today the presentation of clinical data at the American Thoracic Society (ATS) International Conference supporting the safety and efficacy of FG-3019 in patients with idiopathic pulmonary fibrosis (IPF), a debilitating and life-threatening lung disease for which there is currently no approved therapy in the United States.

19 May 2014

Global scientists to discuss latest findings on diagnosis, causes and treatments of ASD

The International Society for Autism Research (INSAR), a scientific and professional organization devoted to advancing knowledge about autism spectrum disorders, convened more than 1700 researchers, delegates, autism specialists and students from 40 countries for the 13th Annual International Meeting for Autism Research (IMFAR), the world's largest scientific gathering on autism research, from May 15 through May 17 at the Atlanta Marriott Marquis in Atlanta, GA.

15 May 2014

Study links triple-negative breast cancer to ethnicity, independent of socioeconomics

An analysis of a large nationwide dataset finds that regardless of their socioeconomic status, black women were nearly twice as likely as white women to be diagnosed with triple-negative (TN) breast cancer, a subtype that has a poorer prognosis.

14 May 2014

Inflammation may accentuate age-related bladder function decline

Age-associated biochemical changes in the bladder may accentuate the inflammation associated with overactive bladder, study findings indicate.

12 May 2014

New drug approach for safer clean-up of deformed blood vessels in eye

A new drug approach has been developed for safer clean-up of deformed blood vessels in the eye by a research team at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital in Toronto.

12 May 2014

Regular grape consumption may help alleviate pain linked with symptomatic osteoarthritis of knee

New research presented last week at the Experimental Biology conference in San Diego, California, suggests that regular grape consumption may help alleviate pain associated with symptomatic osteoarthritis of the knee, and improve joint flexibility and overall mobility.

12 May 2014

New paper offers new insights into role carcinoma-associated fibroblasts play in tumor biology

A new paper by a team of researchers led by Zachary T. Schafer, Coleman Assistant Professor of Cancer Biology in the Department of Biological Sciences at the University of Notre Dame, offers important new insights into the role carcinoma-associated fibroblasts (CAFs) play in tumor biology.

9 May 2014

Clovis Oncology reports net loss of $30.7 million for first quarter 2014

Clovis Oncology, Inc. reported financial results for its first quarter ended March 31, 2014, and provided an update on the Company's clinical development programs for the rest of 2014.

9 May 2014

TAG-1 induces apoptosis-related gene expression without triggering apoptosis in glioma cells

A recent study reported by Haigang Chang and co-workers from the First Affiliated Hospital of Xinxiang Medical University in China verified the effects of transient axonal glycoprotein-1 (TAG-1) on cell viability and p53, epidermal growth factor receptor (EGFR), and amyloid precursor protein (APP) intracellular C-terminal domain (AICD) expression in U251 glioma cells.

8 May 2014

Scientists develop methods to convert non-embryonic stem cells into eye cells

In two separate studies, scientists have developed methods to convert non-embryonic stem cells into eye cells that could be used to restore sight. The research is being presented at the 2014 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) this week in Orlando.

7 May 2014

Novartis presents Phase III results of Signifor LAR therapy in patients with acromegaly

Novartis today presented results from a pivotal Phase III trial of investigational therapy Signifor® LAR (pasireotide LAR; SOM230) in patients with acromegaly for whom current standard of care provides inadequate disease control.

6 May 2014

Researchers identify novel proceed to treat brittle bone disease

Researchers at Baylor College of Medicine have identified a new approach to treating brittle bone disease, a congenital disorder that results in fragile bones that break easily.

5 May 2014

Ranibizumab trial gets promising results for CNV

Patients with visual impairment due to myopic choroidal neovascularisation achieve better visual acuity after 3 months of individualised treatment with ranibizumab than with verteporfin photodynamic therapy, show the results of a phase III randomised controlled trial.

1 May 2014

Gene expression profiling tests play critical role in women’s chemotherapy decision

Gene expression profiling tests play a critical role when women with early-stage breast cancer decide whether to have chemotherapy, but many of them do not fully understand what some of the test results mean, new research suggests.

29 Apr 2014

Study: Functional electrical stimulation promotes neural cell proliferation in brains of rats with cerebral infarction

Previous studies have shown that proliferation of endogenous neural precursor cells cannot alone compensate for the damage to neurons and axons. From the perspective of neural plasticity, Dr. Yun Xiang and co-workers from Sun Yat-sen University in China observed the effects of functional electrical stimulation treatment on endogenous neural precursor cell proliferation and expression of basic fibroblast growth factor and epidermal growth factor in the rat brain on the infarct side.

25 Apr 2014

Study offers evidence supporting use of autologous stem cell-based treatment for stroke

People who have had a stroke, often suffer motor deficits with little potential to restore neurological function.

25 Apr 2014

Studies identify 2 genes highly associated with IBD

Inflammatory Bowel Disease (IBD), a group of chronic inflammatory disorders of the intestine that result in painful and debilitating complications, affects over 1.4 million people in the U.S., and while there are treatments to reduce inflammation for patients, there is no cure.

23 Apr 2014

Growth Factor News and Research

Researchers identify chemical signals that promote breast cancer metastasis

Erlotinib, gefitinib have similar efficacy in NSCLC patients with EGFR mutation

IL-8 expression predicts lung adenocarcinoma prognosis

FibroGen’s Phase 2a study supports safety and efficacy of FG-3019 in IPF patients

Global scientists to discuss latest findings on diagnosis, causes and treatments of ASD

Study links triple-negative breast cancer to ethnicity, independent of socioeconomics

Inflammation may accentuate age-related bladder function decline

New drug approach for safer clean-up of deformed blood vessels in eye

Regular grape consumption may help alleviate pain linked with symptomatic osteoarthritis of knee

New paper offers new insights into role carcinoma-associated fibroblasts play in tumor biology

Clovis Oncology reports net loss of $30.7 million for first quarter 2014

TAG-1 induces apoptosis-related gene expression without triggering apoptosis in glioma cells

Scientists develop methods to convert non-embryonic stem cells into eye cells

Novartis presents Phase III results of Signifor LAR therapy in patients with acromegaly

Researchers identify novel proceed to treat brittle bone disease

Ranibizumab trial gets promising results for CNV

Gene expression profiling tests play critical role in women’s chemotherapy decision

Study: Functional electrical stimulation promotes neural cell proliferation in brains of rats with cerebral infarction

Study offers evidence supporting use of autologous stem cell-based treatment for stroke

Studies identify 2 genes highly associated with IBD

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