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Polyuridine sequence of mouse coronavirus can be targeted to prevent host cell death

A new study reports the use of a modified deoxyribonucleic acid (DNA) oligonucleotide that has a 3’ polyadenine (polyA) tail to bind to the 5’-polyU tract in the mouse coronavirus (MHV-A59). Treatment of mouse cells infected with MHV-A59 with this molecule led to a marked reduction in cell deaths.

2 Aug 2021

Could novel biosensors facilitate SARS-CoV-2 antiviral drug research?

An intriguing new study presents a novel approach to biosensor-based evaluation of promising drugs that could inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via its 3C-like protease (3CLpro), a viral protease.

2 Aug 2021

Intradermal administration of low-dose mRNA COVID-19 vaccine induces strong immune response, study finds

Scientists in the Netherlands recently conducted an open-level, randomized-controlled trial to evaluate the safety and immunogenicity of fractional intradermal doses of the mRNA-based COVID-19 vaccine mRNA-1273 (Moderna). The trial findings reveal that the fractional dose regimen of the Moderna vaccine is well tolerated and safe and is capable of inducing robust antibody responses in vaccine recipients. The study is currently available on the medRxiv* preprint server.

2 Aug 2021

In-depth sequencing of SARS-CoV-2 variants crucial in controlling outbreaks

In this interview, News-Medical speaks to Professor Dana Crawford about her research efforts during the COVID-19 pandemic.

2 Aug 2021

Oh deer! Antibodies to SARS-CoV-2 detected in 40% of wild white-tailed deer in four U.S. states

Researchers conducting a serosurveillance study of a North American deer species have provided evidence of exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among the animals across four U.S. states.

1 Aug 2021

Researchers develop two complementary bladder models to study UTIs

Urinary tract infections (UTIs) are among the most common bacterial infections. They usually require treatment with antibiotics, and almost a quarter of treated cases lead to recurrent infection.

30 Jul 2021

Prior SARS-CoV-2 infection enhances Johnson and Johnson Ad26.COV2.S vaccine immunogenicity

A new study reports that the Johnson and Johnson vaccine against COVID-19 shows enhanced efficacy when administered to individuals with pre-existing antibodies.

30 Jul 2021

Spike-containing virus-like particles induce robust sterilizing immunity against SARS-CoV-2 in macaques

A team of international scientists has recently developed virus-like particles (VLPs) by coating liposomes with the synthetic spike glycoprotein of SARS-CoV-2.

28 Jul 2021

Mini-antibodies efficiently block SARS-CoV-2 virus

Göttingen researchers have developed mini-antibodies that efficiently block the coronavirus SARS-CoV-2 and its dangerous new variants.

28 Jul 2021

T cells are not critical for recovery of primates from acute COVID-19 infections, study reveals

New research conducted in monkeys reveals that T cells are not critical for the recovery of primates from acute COVID-19 infections.

27 Jul 2021

A novel interferon-γ release assay for detection of SARS-CoV-2 specific T-cell response

A new study evaluates a commercially available IFN‐γ release assay (IGRA) to determine T-cell responses targeted against SARS-CoV-2.

26 Jul 2021

Bacteria use a 'sense of touch' mechanism to navigate on surfaces

Many disease-causing bacteria such as Pseudomonas aeruginosa crawl on surfaces through a walk-like motility known as "twitching". Nanometers-wide filaments called type IV pili are known to power twitching, but scientists ignore which sensory signals coordinate the microbes' movements.

23 Jul 2021

CDC monitoring over 200 individuals possibly exposed to monkeypox

The United States Centers for Disease Control and Prevention (CDC) is monitoring over 200 people who may have been exposed to the monkeypox virus.

22 Jul 2021

Cell-analysis method could pave the way for new vaccine strategies against tuberculosis

A new method that analyzes how individual immune cells react to the bacteria that cause tuberculosis could pave the way for new vaccine strategies against this deadly disease, and provide insights into fighting other infectious diseases around the world.

22 Jul 2021

SARS-CoV-2 reprograms host chromatic network to induce immune dysfunction

A recent study conducted at the University of Texas Science Center, Houston, in the USA, has revealed that upon infection, SARS-CoV-2 alters the host chromatin architecture to suppress antiviral interferon-responsive genes and augment inflammatory genes. The study is currently available on the bioRxiv* preprint server.

22 Jul 2021

Research provides new insight into uncontrolled inflammation in COVID-19 patients

Research led by Queen Mary University of London provides new insight into the mechanisms that lead to uncontrolled inflammation in COVID-19 patients.

22 Jul 2021

Scientist explore conserved RNA elements as potential targets for anti-SARS-CoV-2 drugs

The study, published in the journal Angewandte Chemie International Edition, identified many small molecules that bind to certain parts of the SARS-CoV-2 genome that are less likely altered by mutations using dedicated substance libraries. The scientists derived key functional units and groups in ligands for effective and safe targeting of SARS-CoV-2 RNA.

22 Jul 2021

Pathogen News and Research

Polyuridine sequence of mouse coronavirus can be targeted to prevent host cell death

Could novel biosensors facilitate SARS-CoV-2 antiviral drug research?

Intradermal administration of low-dose mRNA COVID-19 vaccine induces strong immune response, study finds

In-depth sequencing of SARS-CoV-2 variants crucial in controlling outbreaks

Oh deer! Antibodies to SARS-CoV-2 detected in 40% of wild white-tailed deer in four U.S. states

Researchers develop two complementary bladder models to study UTIs

Prior SARS-CoV-2 infection enhances Johnson and Johnson Ad26.COV2.S vaccine immunogenicity

Spike-containing virus-like particles induce robust sterilizing immunity against SARS-CoV-2 in macaques

Mini-antibodies efficiently block SARS-CoV-2 virus

T cells are not critical for recovery of primates from acute COVID-19 infections, study reveals

A novel interferon-γ release assay for detection of SARS-CoV-2 specific T-cell response

Bacteria use a 'sense of touch' mechanism to navigate on surfaces

CDC monitoring over 200 individuals possibly exposed to monkeypox

Cell-analysis method could pave the way for new vaccine strategies against tuberculosis

SARS-CoV-2 reprograms host chromatic network to induce immune dysfunction

Research provides new insight into uncontrolled inflammation in COVID-19 patients

Scientist explore conserved RNA elements as potential targets for anti-SARS-CoV-2 drugs

Scientists seek to block pathogen’s most reliable weapon to cause severe malaria

Scientists identify gut microbiota dysbiosis as a potential risk factor for long COVID

COVIDcast API: An open repository of real-time COVID-19 indicators

Best practices - optimize qPCR processes for pathogen detection eBook

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