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Triple antibody cocktail is a promising candidate for immunotherapy against SARS-CoV-2 variants of concern

Researchers generated a panel of bnAbs against SARS-CoV, SARS-CoV-2, and its variant VOCs, including Omicron from sequentially immunized mice.

28 Feb 2022

Study finds Omicron sublineage BA.2 is less pathogenic in rodent models than prior SARS-CoV-2 variants

Researchers evaluated the pathogenicity and replication potential of SARS-CoV-2 VOC Omicron lineage, BA.2 in immunocompetent mice and hamsters.

28 Feb 2022

Noncovalent protease inhibitors against SARS-CoV-2 and other coronaviruses

In a new study published in ACS Infectious Diseases journal, scientists biochemically and structurally evaluated the PLpro from a subgroup 2b bat coronavirus, BtSCoV-Rf1.2004, to identify unique structural features or enzymatic biases of the subgroup 2b.

28 Feb 2022

Harvard’s new kidney engineering technology licensed to San Diego-based Trestle Biotherapeutics

A newly launched startup is building upon innovations developed over several years at the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering & Applied Sciences (SEAS), and Brigham and Women’s Hospital (Brigham) to engineer functional kidney tissue for renal repair and replacement therapy.

25 Feb 2022

Osteoblast-derived vesicles regulate the switch from bone formation to resorption via a miRNA-mediated mechanism

Osteoblasts act in a group to make bone over the course of several months. However, how osteoblasts cooperate with each other in vivo is still unknown.

25 Feb 2022

Should SARS-CoV-2 Omicron be considered a serotype?

A recent article provides evidence for and against the hypothesis of SARS-CoV-2 serotypes.

24 Feb 2022

Deep-learning based image reconstruction approach may improve detection of breast cancer

Researchers have developed a new image reconstruction approach that could contribute to better breast cancer detection. The deep learning algorithm overcomes a major hurdle in multi-modality imaging by allowing images to be recovered in real time.

24 Feb 2022

Study explores the boosting of SARS-CoV-2 adenovirus vaccine-induced immunity by capsid decoration

Researchers demonstrated that decorating the capsid surface of adenovirus vaccine vectors with a newly discovered protein superglue, DogTag/DogCatcher generates potent SARS-CoV-2-specific humoral and cellular immunity.

24 Feb 2022

Study reveals sex-dimorphic immune imprints and in vivo functional impacts of mild COVID-19

Researchers used a systems immunology approach to analyze the immune states of healthy and non-obese subjects who recovered from mild COVID-19 and compared them with age- and sex-matched COVID-19-naive controls.

24 Feb 2022

Scientists discover how a rare genetic disorder disrupts key neural interactions in the developing brain

Every time you chew, talk, yawn, or sense the zap of a toothache, cranial nerve cells are shuttling electrochemical signals to your brain.

23 Feb 2022

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

The role played by the host enzyme TMPRSS2 in infection and cancer is the focus of a new study.

23 Feb 2022

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

In a recent study posted to the Research Square* preprint server, which is under consideration at Scientific Reports, a team of researchers developed a novel human Alveolar Epithelial Lentivirus immortalized (hAELVi) cell infection model to estimate the replication potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses in the lower respiratory tract of humans.

23 Feb 2022

Exploring the potential of mosaic RBD nanoparticles to fight SARS-CoV-2

Researchers explore the potential of mosaic receptor-binding domain nanoparticles in protective immunity against SARS-CoV-2

22 Feb 2022

New method to develop nanoengineered bacteria for photothermal cancer immunotheranostics

There is substantial interest regarding the understanding and designing of nanoengineered bacteria to combat various fatal cancerous diseases.

22 Feb 2022

Study offers a new, effective therapeutic option against glioblastoma

A study recently accepted for publication in The Journal of Clinical Investigation describes a new and effective therapy to treat glioblastoma: the concomitant use of ADI-PEG20 together with focal brain radiotherapy.

22 Feb 2022

Study provides a potent biparatopic antibody against all SARS-CoV-2 variants of concern

Researchers demonstrated the potent neutralization of SARS-CoV-2 VOCs, including Omicron by the biparatopic human heavy chain variable domain.

22 Feb 2022

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

Researchers investigate the potential of picolinic acid (PA) as an anti-SARS-CoV-2 treatment option.

21 Feb 2022

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Researchers at The University of Texas MD Anderson Cancer Center have developed a new radio-labeled molecule capable of selectively reacting with certain high-energy radicals that are characteristic of innate immune activity, which may allow a non-invasive approach to monitor inflammation in real time by positron emission tomography (PET) imaging.

21 Feb 2022

Novel ACE2-blocking antibody protects against all SARS-CoV-2 VOCs

Researchers identify 87G7, a SARS-CoV-2 neutralizing human monoclonal antibody with remarkable broad-spectrum neutralization and protection efficacy.

21 Feb 2022

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Researchers demonstrated the composition and importance of SARS-CoV-2 lipid envelope and assessed the antiviral potential of oral mouthwashes targeting these lipid envelopes.

21 Feb 2022

in vivo News and Research

Triple antibody cocktail is a promising candidate for immunotherapy against SARS-CoV-2 variants of concern

Study finds Omicron sublineage BA.2 is less pathogenic in rodent models than prior SARS-CoV-2 variants

Noncovalent protease inhibitors against SARS-CoV-2 and other coronaviruses

Harvard’s new kidney engineering technology licensed to San Diego-based Trestle Biotherapeutics

Osteoblast-derived vesicles regulate the switch from bone formation to resorption via a miRNA-mediated mechanism

Should SARS-CoV-2 Omicron be considered a serotype?

Deep-learning based image reconstruction approach may improve detection of breast cancer

Study explores the boosting of SARS-CoV-2 adenovirus vaccine-induced immunity by capsid decoration

Study reveals sex-dimorphic immune imprints and in vivo functional impacts of mild COVID-19

Scientists discover how a rare genetic disorder disrupts key neural interactions in the developing brain

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

Exploring the potential of mosaic RBD nanoparticles to fight SARS-CoV-2

New method to develop nanoengineered bacteria for photothermal cancer immunotheranostics

Study offers a new, effective therapeutic option against glioblastoma

Study provides a potent biparatopic antibody against all SARS-CoV-2 variants of concern

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Novel ACE2-blocking antibody protects against all SARS-CoV-2 VOCs

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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