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Mediterranean diet wins on weight but misses on memory in diverse aging population

A 14-month randomized trial in older African American adults with obesity found that adopting a Mediterranean diet, with or without calorie-restricted weight loss, significantly improved diet quality and reduced body weight and visceral fat. However, no cognitive benefits were observed compared to usual diet.

2 Jul 2025

Caltech researchers develop safer and smarter breast imaging technique

A Caltech-led team has developed a safe, effective, and painless breast imaging technique that incorporates machine learning to help differentiate between suspicious and healthy tissue.

30 Jun 2025

Gene therapy shows promise for reducing stroke risk in patients with sickle cell disease

Gene therapy for sickle cell disease may help improve a major contributing factor to stroke risk in patients, reports a new study from St. Jude Children's Research Hospital.

30 Jun 2025

Just 150 minutes of exercise a week could reverse prediabetes

Engaging in more than 150 minutes of physical activity per week quadrupled the odds of reversing prediabetes to normal glucose levels in Colombian adults. Higher BMI and HbA1c remained strong barriers to reversal, highlighting the power of lifestyle interventions.

29 Jun 2025

Methylene blue emerges as an adjunct in septic shock

Recent evidence suggests methylene blue may help reduce vasopressor needs and ICU stays in septic shock, but current data do not support replacing standard therapies. Further research is needed to clarify its optimal dosing, timing, and patient selection for best outcomes.

26 Jun 2025

Tirzepatide rewires appetite and slashes calorie intake in new obesity trial

A 6-week randomized trial found that tirzepatide significantly reduced energy intake, appetite, and cravings in adults with overweight or obesity, outperforming liraglutide and placebo. Brain imaging revealed that tirzepatide also lowered neural responses to high-fat, high-sugar food cues, offering mechanistic insight into its potent weight-loss effects.

25 Jun 2025

Once-monthly obesity injection shows double-digit weight loss in major clinical trial

Researchers found that once-monthly maridebart cafraglutide led to substantial weight loss and improved glycemic control in adults with obesity, with or without diabetes, in a phase 2 randomized trial. The drug demonstrated an acceptable safety profile and supports further study in phase 3 trials.

24 Jun 2025

Amycretin delivers unprecedented weight loss in early trial for obesity treatment

Once-weekly amycretin, a novel peptide activating GLP-1, amylin, and calcitonin receptors, produced rapid, substantial, and sustained weight loss in adults with overweight or obesity during a phase 1b/2a trial. The treatment was generally well tolerated, with mostly mild to moderate gastrointestinal side effects, supporting further investigation in larger, longer studies.

23 Jun 2025

Use of sleep heart rate patterns to forecast diabetes risk in pregnancy

This study highlights the potential of heart rate variability as an early indicator of gestational diabetes, facilitating proactive healthcare in pregnancy.

23 Jun 2025

FIM programs show promise in improving diet quality and food security

Food is medicine (FIM) programs that incorporate healthy food into health care for people with or at high risk for chronic disease show great potential in improving diet quality and food security, but additional research is needed to understand clinical outcomes, according to a systematic review of randomized controlled trials in the U.S conducted by the American Heart Association.

19 Jun 2025

New gene therapy strategy reactivates dormant genes to treat blood disorders

Researchers have found a promising new method for gene therapy. They successfully restarted inactive genes by bringing them closer to genetic switches on the DNA called enhancers.

19 Jun 2025

Meal and sleep timing play key roles in diabetes prevention

High-resolution digital tracking reveals how daily habits, meal timing, sleep, and physical activity shape metabolic risk for type 2 diabetes. Meal timing, sleep patterns, and activity windows each play distinct roles in insulin resistance and glucose control.

12 Jun 2025

Uncovering the genetic link between type 2 diabetes and brain structure

Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disorder worldwide. Beyond glucose dysregulation, it exerts significant effects on the central nervous system.

11 Jun 2025

Digital twin technology improves diabetes control with artificial pancreas

New technology that allows a University of Virginia-developed artificial pancreas system to adapt to users' changing bodies – and lets users test changes to how the system operates – improved control of their type 1 diabetes, a study has found.

10 Jun 2025

Plant-based portfolio diet linked to fewer heart-related deaths

The portfolio diet significantly lowers heart disease risk, with long-term benefits for cardiovascular health and all-cause mortality in diverse populations.

3 Jun 2025

Heavy smoking triggers systemic inflammation and vascular damage in new biomarker study

Heavy smoking in adult males significantly increases oxidative stress, inflammation, and vascular dysfunction, as shown by comprehensive blood and tissue biomarker analysis. The findings highlight measurable biological damage and reinforce the urgent need for targeted public health interventions.

26 May 2025

Chokeberry juice reduces blood vessel resistance in people with pre-diabetes

A German crossover trial found that drinking polyphenol-rich red berry juice improved peripheral resistance and helped preserve muscle mass in pre-diabetic adults. No significant changes were seen in glucose control or oxidative stress over the 14-day interventions.

12 May 2025

How urine caffeine levels may help detect diabetic eye damage early

Researchers found that higher urinary levels of caffeine and specific metabolites, especially in men, were significantly associated with diabetic retinopathy risk. The cross-sectional study used NHANES 2009–2014 data and highlights potential biomarkers for early detection in diabetic populations.

7 May 2025

Low testosterone linked to higher kidney stone risk in men, study finds

A large cross-sectional study in South Korea found that men with low testosterone levels (below 3.33 ng/mL) were significantly more likely to have kidney stones. This association held even after adjusting for age and metabolic risk factors, suggesting testosterone may play a protective role.

6 May 2025

Semaglutide clears liver inflammation and cuts fibrosis in MASH patients, trial shows

A phase 3 trial shows that once-weekly semaglutide significantly improves liver histology in patients with metabolic dysfunction-associated steatohepatitis (MASH). The interim results also reveal meaningful weight loss and improved cardiometabolic markers, with a favorable safety profile.

4 May 2025