Microscopy News and Research

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Direct electron introduces Apollo

Direct Electron, a leading producer of next-generation direct detection cameras for transmission electron microscopes (TEM), today announces Apollo, a revolutionary new event-based direct detection camera for electron cryo-microscopy (cryo-EM). Based on a next generation sensor and camera architecture delivering electron counting in hardware, Apollo is the highest throughput direct detector for cryo-EM.

From Direct Electron, LP 4 Mar 2021

Researchers identify drug target to fight Parkinson’s and Alzheimer’s disease

Neurodegenerative disorders such as Parkinson's and Alzheimer's disease are in the firing line after researchers identified an attractive therapeutic drug target.

3 Mar 2021

$High-resolution imaging, 3D computer modeling reveal the fractal nature of neurons$

High-resolution imaging, 3D computer modeling reveal the fractal nature of neurons

High-resolution imaging and 3D computer modeling show that the dendrites of neurons weave through space in a way that balances their need to connect to other neurons with the costs of doing so.

3 Mar 2021

COVID-19 disrupts heart muscle contraction, may lead to heart failure

Since early in the pandemic, COVID-19 has been associated with heart problems, including reduced ability to pump blood and abnormal heart rhythms.

3 Mar 2021

Study reveals how cells build 'mini-muscles' underneath their nucleus

Research groups at the University of Helsinki uncovered how motor protein myosin, which is responsible for contraction of skeletal muscles, functions also in non-muscle cells to build contractile structures at the inner face of the cell membrane.

2 Mar 2021

Researchers explore early stages of ribosome formation to identify new targets for antibiotics

Ribosome formation is viewed as a promising potential target for new antibacterial agents. Researchers from Charité - Universitätsmedizin Berlin have gained new insights into this multifaceted process.

2 Mar 2021

Researchers study the digestion process of drug-loaded DNA nanostructures in real time

DNA nanotechnology - the research field using DNA molecules as building material - has developed rapidly during recent years and enabled the construction of increasingly complex nanostructures.

2 Mar 2021

Newly discovered protein regulates molecular motors in response to light

Single-celled algae and animal sperm cells are widely separated in evolution but both swim in the same way, by waving their protruding hairs, called cilia or flagella. Motion is driven by molecular motors, complex assemblies of proteins that exert a force when changing shape.

1 Mar 2021

New method to enhance images of the SARS-CoV-2 virus

Researchers report a method of removing noise from high-resolution transmission electron microscopy images using probabilistic generative models.

28 Feb 2021

Commonly used sweeteners may promote antibiotic resistance

Researchers in Australia have conducted a study showing that commonly used nonnutritive sweeteners can promote the spread of antibiotic-resistant genes in the intestine.

28 Feb 2021

New 'E-Morph' test method replaces animal experiments to detect hormone-like effects

Endocrine disruptors (EDs) are hormone-like substances that can have undesirable effects on health. For example, chemicals can increase the risk of breast cancer if they act in a manner similar to the female sex hormone estrogen.

26 Feb 2021

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

A new study by researchers at Brookhaven National Laboratory and Stony Brook University in the U.S. describes the key interaction between the viral envelope (E) protein and the human cell junction protein, PALS1. The latter is necessary to establish and maintain cell polarity and tight junctions between cells.

26 Feb 2021

Borosilicate Glass Microplates Improve Imaging Sensitivity

Porvair Sciences new Krystal™ Glass Bottom microplate with high quality specialty glass from Schott provides unmatched performance for whole-plate CCD imaging and laser detection applications.

From Chromatrap® - Porvair Sciences Ltd 26 Feb 2021

Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells

The clinical phenotype of COVID-19, caused by SARS-CoV-2, is remarkable for its wide range of severity among individual patients. Genetic variations are known to mediate part of these differences. To examine these differences, researchers in a new study used human induced pluripotent stem cells (iPSCs) from different genetically diverse individuals. These cells are used to model genetic disease since they contain the donor’s genetic information. Researchers use a panel of iPSCs from over 500 individuals. The researchers preferred undifferentiated iPSCs to reduce the time required to differentiate them, especially since infection is not always reliable.

25 Feb 2021

Novel single-particle digital assay using plasmonic nanobubbles

An interdisciplinary team from the University of Texas applied DIAMOND to the respiratory syncytial virus (RSV) diagnostics and demonstrated that DIAMOND is 150 times more sensitive than commercial lateral flow assays. They found that the measurements are completed within 2 minutes. The results of this study are published on the medRxiv* preprint server.

25 Feb 2021

KTH researchers identify 300 proteins that regulate cell division process

With the hope of contributing to the fight against cancer, researchers in Sweden have published a new molecular mapping of proteins that regulate the cell division process - identifying 300 such proteins.

24 Feb 2021

AI-based 3D holographic microscopy found to be better at analyzing cancer immunotherapy

Live tracking and analyzing of the dynamics of chimeric antigen receptor (CAR) T-cells targeting cancer cells can open new avenues for the development of cancer immunotherapy.

24 Feb 2021

Microfluidic chip and AI-powered automated microscope help measure hemoglobin levels

One of the most performed medical diagnostic tests to ascertain the health of patients is a complete blood count, which typically includes an estimate of the hemoglobin concentration.

24 Feb 2021

Researchers use powerful X-rays to analyze brain tissues of schizophrenia patients

Schizophrenia, a chronic, neurological brain disorder, affects millions of people around the world. It causes a fracture between a person's thoughts, feelings and behavior.

24 Feb 2021

Two potent SARS-CoV-2 neutralizing antibodies effective against B.1.351 and B.1.1.7 variants

By analyzing the cryoEM structures of antibodies against the SARS-CoV-2 virus, researchers report that the neutralizing capabilities of two antibodies are not affected by new strains as these antibodies target regions of the virus away from the ACE2 binding regions.

23 Feb 2021

Microscopy News and Research

Direct electron introduces Apollo

Researchers identify drug target to fight Parkinson’s and Alzheimer’s disease

High-resolution imaging, 3D computer modeling reveal the fractal nature of neurons

COVID-19 disrupts heart muscle contraction, may lead to heart failure

Study reveals how cells build 'mini-muscles' underneath their nucleus

Researchers explore early stages of ribosome formation to identify new targets for antibiotics

Researchers study the digestion process of drug-loaded DNA nanostructures in real time

Newly discovered protein regulates molecular motors in response to light

New method to enhance images of the SARS-CoV-2 virus

Commonly used sweeteners may promote antibiotic resistance

New 'E-Morph' test method replaces animal experiments to detect hormone-like effects

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

Borosilicate Glass Microplates Improve Imaging Sensitivity

Study explores individual differences of SARS-CoV-2 infection in ACE2-expressing stem cells

Novel single-particle digital assay using plasmonic nanobubbles

KTH researchers identify 300 proteins that regulate cell division process

AI-based 3D holographic microscopy found to be better at analyzing cancer immunotherapy

Microfluidic chip and AI-powered automated microscope help measure hemoglobin levels

Researchers use powerful X-rays to analyze brain tissues of schizophrenia patients

Two potent SARS-CoV-2 neutralizing antibodies effective against B.1.351 and B.1.1.7 variants

Industry Focus eBook - Life Science Microscopy (2nd Edition) eBook

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