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A promising strategy to overcome drug resistance developed by blood cancer cells

In a collaborative study published in Blood Advances, a research group led by Beate Heissig at Juntendo University and Yousef Salama at An Najah University report a strategy to overcome drug resistance developed by blood cancer cells.

27 Mar 2020

Roscovitine enhances nuclear enrichment of traditionally cytoplasmic signaling molecules

Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear enrichment of certain traditionally cytoplasmic signaling molecules and enhanced differentiation and cell cycle arrest.

26 Mar 2020

Lipid aids healing of scratches on the cornea

A species of a lipid that naturally helps skin injuries heal appears to also aid repair of common corneal injuries, even when other conditions, like diabetes, make healing difficult, scientists report.

26 Mar 2020

Overexpression of hPCL3S could contribute to tumor progression in prostate cancer

The cover for issue 12 of Oncotarget features Figure 11, "Global analyses of the RNA-Seq data of LNCaP empty vector and LNCaP cells overexpressing hPCL3S (Clone 12)" by Abdelfettah, et al.

25 Mar 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

DSI alumni use computational design to quickly discover treatments for COVID-19

Two graduates of the Data Science Institute at Columbia University are using computational design to quickly discover treatments for the coronavirus.

21 Mar 2020

New UCI-led study reveals how skin cells prepare to heal wounds

Scientists have revealed how skin cells prepare to heal, potentially leading to better understanding of healing within diabetes.

20 Mar 2020

Study reveals major changes that occur in mammalian skin cells during wound healing

A team of University of California, Irvine researchers have published the first comprehensive overview of the major changes that occur in mammalian skin cells as they prepare to heal wounds.

19 Mar 2020

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

The cover for issue 11 of Oncotarget features Figure 6, "Effects of AZD8186 in combination with anti-PD1 on syngeneic models," by Owusu-Brackett, et al.

18 Mar 2020

Strict measures to halt coronavirus spread will reduce deaths

Amid the coronavirus global pandemic, it is still unclear which government measures are useful in curbing the spread of the virus. Some countries had imposed lockdowns and community quarantines, while others took time to restrict population movement before they closed schools and nonessential businesses. Others are still allowing regular routines despite an increasing number of infections.

18 Mar 2020

NCAM2 protein is a vital factor in the formation of cerebral cortex, neuronal morphogenesis

The molecule NCAM2, a glycoprotein from the superfamily of immunoglobulins, is a vital factor in the formation of the cerebral cortex, neuronal morphogenesis and formation of neuronal circuits in the brain, as stated in the new study published in the journal Cerebral Cortex.

13 Mar 2020

What does COVID-19 do to the body?

The novel coronavirus SARS-CoV-2, also known as 2019-nCoV, is the virus that causes COVID-19, and that is spreading throughout the world is causing panic in almost all countries. With a death rate ranging from 1% to 2% in young patients but about 5%-8% in elderly and sick patients, it is capable of ravaging multiple organ systems in the human body.

12 Mar 2020

Understanding how cancer cells interact and collaborate to metastasize

Cancer cells are known to migrate and collaborate to form networks that function as conduits providing access to nutrients and blood vessels.

12 Mar 2020

Blood test for microbial DNA could warn of cancer

A new study published in the journal Nature on March 11, 2020, could transform the currently held views on cancer causation and diagnosis. The researchers have come up with a new technique to detect the presence and type of cancer by looking at microbial DNA circulating in the blood of the person being screened.

11 Mar 2020

Study identifies a mutation that triggers deadly amyloidosis

Bone marrow plasma cells produce antibodies. These comprise two long and two short protein chains. The pathological proliferation of plasma cells can lead to an overproduction of the short chains.

10 Mar 2020

Combination of anti-cancer nanodrugs with Intralipid enhances therapeutic efficacy

Pairing chemotherapy nanodrugs with a nutritional supplement can lessen devastating side-effects while reducing the amount of the expensive drugs needed to treat cancer according to a study from Carnegie Mellon University and Taiwan's National Health Research Institutes.

10 Mar 2020

Researchers explore the role of SLC25A32 in cancer cell proliferation

Oncotarget Volume 11 Issue 8 reported that while it is known that cancer cells require one-carbon and FAD-dependent mitochondrial metabolism to sustain cell proliferation, the role of SLC25A32 in cancer cell growth remains unexplored.

28 Feb 2020

New discovery may be useful for developing novel cancer treatments

Researchers from the University of Copenhagen have discovered that our cells replicate their DNA much more loosely than previously thought.

28 Feb 2020

Cancer chemical from common gut microbe

Many common gut bacteria carry cancer-causing mutations, says a new study published in the journal Nature on the 27th February 2020.

27 Feb 2020

Study analyzes the effect of maternal smoking on newborns’ body size and proportion

Although quitting smoking during the 1st trimester of pregnancy reduces the risk of low birth weight, it isn't enough to protect the unborn child from being born shorter and with smaller brain size, a new study from the University of Eastern Finland shows.

26 Feb 2020