Proliferation News and Research

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Discovery identifies an adaptation by cancer cells that promotes metastasis

The discovery identifies an adaptation by cancer cells that facilitates their spreading to distant sites, and the potential for targeting these features to prevent or slow the progression of metastatic hormone receptor-positive breast cancer.

12 Feb 2020

Major breakthrough in understanding how malaria parasite grows and multiplies

Scientists have made a major breakthrough in understanding how the parasite that causes malaria is able to multiply at such an alarming rate, which could be a vital clue in discovering how it has evolved, and how it can be stopped.

11 Feb 2020

Study explores how some mammals postpone development of their embryos

How do some mammals postpone the development of their embryos to await better conditions for having offspring? A recent study at the UW Medicine Institute for Stem Cell and Regenerative Medicine explored this reproductive enigma, which can occur in more than 130 species of mammals as well as in some marsupials.

10 Feb 2020

CD19 CAR NK cell therapy clinical trial shows encouraging results for hematologic cancers

According to results from a Phase I/IIa trial at The University of Texas MD Anderson Cancer Center, treatment with cord blood-derived chimeric antigen receptor natural killer (NK)-cell therapy targeting CD19 resulted in clinical responses in a majority of patients with relapsed or refractory non-Hodgkin's lymphoma and chronic lymphocytic leukemia, with no major toxicities observed.

6 Feb 2020

Largest genome study sheds light on how genetic glitches trigger tumor formation

It is well-known that when a gene mutates, it triggers tumor formation by stimulating abnormal cell growth and proliferation. Cancer starts from a mutant gene that kickstarts a series of abnormal growth, forming a tumor. However, the exact mechanism of how this happens remains unclear.

6 Feb 2020

Study suggests potential therapy option for early-stage breast cancer

Radionuclide therapy has proven successful in delaying the growth of disseminated tumor cells (DTCs) in early-stage breast cancer in a small animal model, suggesting its use as a potential adjuvant therapy for retarding the proliferation of DTCs.

5 Feb 2020

Age-linked cognitive decline could be slowed by immune activation

A new study published in February 2020 in the Journal of Experimental Medicine (JEM), reports that activating a specific type of immune cell found in the brain could delay reduced cognition often found in older people, and even prevent neurologic degeneration of age.

5 Feb 2020

Targeting the microenvironment of cancer cells to inhibit tumor growth

The recognition of bacterial infections or foreign substances is mediated and controlled by the human immune system. This innate and adaptive immune system comprises the most important metabolic and cellulare processes to fight against infections and other diseases.

5 Feb 2020

Good rehab is hard to find

Pattie Vargas saw with frightening clarity that her son Joel, 25 at the time, had a life-threatening drug problem. He came home one day in 2007 "high as a kite," went to bed and slept four days straight, Vargas, now a 65-year-old resident of Vacaville, California, recalls.

5 Feb 2020

Heart muscle cells of zebrafish change their metabolism during heart regeneration

Researchers from the group of Jeroen Bakkers at the Hubrecht Institute have found that the muscle cells in the heart of zebrafish change their metabolism, the way in which they generate energy, during heart regeneration.

5 Feb 2020

Princeton researchers find link between microbes and cancers in threatened California foxes

Can staph microbes lead to cancer? Microbes are known to affect digestion, mood and overall health, and now Princeton researchers have shown that a shift in the microbiome is linked to cancer -- at least in a threatened subspecies of foxes found only on one island off the California coast.

4 Feb 2020

Study reveals new strategies to prevent skin scarring

A new study in Burns & Trauma, published by Oxford University Press, reveals promising new strategies to prevent skin scarring after injuries.

4 Feb 2020

New step toward understanding cancer prevention in evolutionary terms

A new Scientific Reports paper puts an evolutionary twist on a classic question. Instead of asking why we get cancer, Leonardo Oña of Osnabrück University and Michael Lachmann of the Santa Fe Institute use signaling theory to explore how our bodies have evolved to keep us from getting more cancer.

4 Feb 2020

Ludwig Cancer Research study develops a safer CAR-T therapy

A Ludwig Cancer Research study has devised a new type of chimeric antigen-receptor (CAR) T cell - a family of promising immunotherapies for cancer- that can be switched on and off on demand.

3 Feb 2020

Choice of anesthetic for breast tumor resection may influence cancer outcomes

A study led has added to the evidence that the type of anesthetic administered to cancer patients during tumor surgical resection may affect cancer outcomes.

31 Jan 2020

Turning stink into therapy for atherosclerosis

In an amusing but amazing turnaround, it seems the most foul-smelling compound on earth, called putrescine, could help relieve chronic inflammation, most importantly in the arterial thickening called atherosclerosis. This discovery is reported in the journal Cell Metabolism in January 2020.

30 Jan 2020

Increased brain growth, mutations and autism linked in new study

Salk Institute researchers have now found a pattern of DNA damage that is unique to brain cells derived from individuals with a single form of autism spectrum disorder (ASD) called macrocephalic ASD. The study, published in the journal Cell Stem Cell in January 2020, may offer an explanation about the developmental misstep that caused this disease.

30 Jan 2020

Study may help develop ibrutinib-based combination therapies for blood cancer

Chronic lymphocytic leukemia (CLL) is the most common form of blood cancer (leukemia) in the Western world, affecting approximately 1.2% of all cancer patients.

30 Jan 2020

Research reveals key molecular target for colorectal cancer therapy

Serine racemase is a multifunctional enzyme that carries out several different reactions in human cells, including the conversion of L-serine into pyruvate.

29 Jan 2020

Study shows protective cells reduce lung cancer risk in ex-smokers

A new study could explain how lung cancer risk is reduced by quitting smoking. Published in the journal Nature in January 2020, the study shows that ex-smokers have a greater number of lung cells that have healthy genes compared to current smokers. Healthy genes are less likely to transform into cancerous cells.

29 Jan 2020