Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

The obesity paradox

It's called the obesity paradox. Although obese people are more apt to suffer from inflammatory diseases, such as diabetes, heart disease, and stroke, they are also more likely to survive a major attack caused by one of those conditions.

26 Feb 2009

Immune system found to be more versatile than previously thought

By studying how mice fight off infection by intestinal worms - a condition that affects more than 1 billion people worldwide - scientists have discovered that the immune system is more versatile than has long been thought.

26 Feb 2009

Two compounds show great promise for cerebral palsy

Two compounds developed by Northwestern University chemists have been shown to be effective in pre-clinical trials in protecting against cerebral palsy, a condition caused by neurodegeneration that affects body movement and muscle coordination.

25 Feb 2009

Stat3 signaling tips the balance of immunity in favor of cancer

New research reveals how a cancer-associated protein enables tumor cells to evade the immune system by both suppressing antitumor influences and promoting tumor-enhancing conditions, in essence turning the immune system to the dark side of the force.

2 Feb 2009

New genetic clues on molecular evolution of Q fever pathogen

Scientists from the National Institute of Allergy and Infectious Diseases, Texas A&M Health Center, and the Virginia Bioinformatics Institute at Virginia Tech have uncovered genetic clues about why some strains of the pathogen Coxiella burnetii are more virulent than others.

2 Feb 2009

Helicobacter pylori can multiply in autophagic vesicles

Helicobacter pylori , a Gram-negative, flagellated, microaerophilic bacterium, can selectively colonize in the human stomach.

29 Jan 2009

Lisofylline drug improves type 2 insulin action; reduces harm of fat in preclinical study

Results of a preclinical study involving DiaKine Therapeutics' lead drug candidate Lisofylline (LSF) indicate the compound may reduce two key risk factors for type 2 diabetes.

23 Jan 2009

New folate antagonists selectively target pathway important in rheumatoid arthritis

Methotrexate (MTX), a folate antagonist that blocks folic acid activity, is the most widely used disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis.

13 Jan 2009

Tuberculosis commandeers body's defenses to gain foothold

Tuberculosis bacteria can commandeer the body's defenses in the early stages of infection and redirect them for their own offensive strategies, according to results reported in the scientific journal, Cell.

9 Jan 2009

New avenue for TB therapy

Masses of immune cells that form as a hallmark of tuberculosis (TB) have long been thought to be the body's way of trying to protect itself by literally walling off the bacteria.

8 Jan 2009

Active Hexose Correlated Compound shown to enhances immune system by increasing production of key dendritic cells

A recently published study in Nutrition and Cancer (60(5), 643-651) by researchers at Kansai Medical University in Osaka, Japan has shown that AHCC (Active Hexose Correlated Compound) enhances immune function by increasing the number of dendritic cells (DCs).

6 Jan 2009

Lung cancer cells activate inflammation to induce metastasis

A research team from the University of California, San Diego School of Medicine has identified a protein produced by cancerous lung epithelial cells that enhances metastasis by stimulating the activity of inflammatory cells.

1 Jan 2009

Key survival circuit discovered in Salmonella bacteria

Hundreds of trillions of bacteria make their home in the vertebrate gut. Though many of these microbes perform helpful duties for their host, others - the pathogens - are unwelcome visitors, causing disease.

17 Dec 2008

Mucosal lining of the female genital tract no barrier to HIV sexual transmission

Contrary to a widely-held assumption about heterosexual transmission of HIV, the normal mucosal lining of the female genital tract is not a foolproof barrier to viral penetration, scientists at the Northwestern University School of Medicine in Chicago report at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco.

16 Dec 2008