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Breakthrough gene discovery offers new hope for medulloblastoma therapy

Scientists at The Hospital for Sick Children (SickKids) have identified a key gene that could lead to next-generation treatments for medulloblastoma, the most common malignant brain tumor in children.

24 Jan 2025

NUS researchers develop DNA barcoded nanoparticles for targeted cancer therapy

A team of researchers from the National University of Singapore (NUS) has developed a novel method to enhance the precision of cancer treatment using gold nanoparticles tagged with DNA barcodes.

24 Jan 2025

Breakthrough study targets tumor cell clusters to prevent metastasis

Certain tumor types do not remain at their point of origin but spread throughout the body and form metastases.

24 Jan 2025

Multi-omics approach identifies potential drug combinations for AML treatment

Acute myeloid leukaemia (AML) is mainly characterized by an increase in the number of myeloid cells in the bone marrow and a decrease in mature cells, accounting for 28% of leukaemia cases, with a five-year survival rate of only 30.5%.

23 Jan 2025

New approach to treating ependymoma with leukemia drug

Rakesh Jain PhD, Director of the E.L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital and A. Werk Cook Professor of Radiation Oncology at Harvard Medical School, is senior author of a new study in PNAS, Targeting EPHB2/ABL1 Restores Anti-Tumor Immunity in Preclinical Models of Ependymoma.

23 Jan 2025

Researchers map genetic differences across children with Wilms tumor

Genetically tailored treatment plans for children with a type of kidney cancer could help provide the most effective care while minimizing side effects as much as possible.

23 Jan 2025

Metronomic chemotherapy offers hope for children with neuroblastoma

Neuroblastoma is the most common extracranial solid tumor in children, with nearly 50% of cases diagnosed at an advanced stage, often with metastatic disease.

23 Jan 2025

Researchers investigate a new combination therapy against cancer

A research team at the Medical University of Vienna led by Maria Sibilia has investigated a new combination therapy against cancer.

23 Jan 2025

AGA releases updated guidelines on hepatitis B reactivation in patients on immunosuppressive drugs

The American Gastroenterological Association (AGA) has unveiled an updated clinical practice guideline in Gastroenterology addressing the prevention and management of hepatitis B virus reactivation (HBVr) in patients on immunosuppressive drugs.

23 Jan 2025

Insilico Medicine doses first patient in Phase I Trial of ISM6331 for mesothelioma

Insilico Medcine( "Insilico") , a clinical stage generative artificial intelligence (AI)-driven biotechnology company today announced the first patient has been dosed in the global multicenter Phase I Trial of ISM6331, a novel pan-TEAD inhibitor developed from Insilico's generative chemistry engine Chemistry42, for the treatment of mesothelioma and other solid tumors.

22 Jan 2025

New copper detection tool may lead to lung cancer treatment breakthrough

The Chang Lab at Princeton Chemistry continues in its mission to elucidate the role of metal nutrients in human biology: last year, iron; this year, copper.

22 Jan 2025

Single dose of novel drug shows tumor-clearing potential in breast cancer models

Despite significant therapeutic advances, breast cancer remains a leading cause of cancer-related death in women.

22 Jan 2025

Study offers insight into how senescent cells survive after cancer treatment

After treating a tumor with chemotherapy and radiotherapy, cells known as senescent cells can appear.

22 Jan 2025

Muscle fat infiltration predicts heart disease risk better than BMI, study finds

Skeletal muscle fat infiltration (IMAT) is linked to coronary microvascular dysfunction and increased cardiovascular risk, independent of BMI and traditional risk factors.

21 Jan 2025

Study finds anti-correlation of KLRG1 and PD-1 expression in tumor fighting T cells

A new research paper was published in Oncotarget's Volume 16 on January 20, 2025, titled "Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells."

21 Jan 2025

Research shows epigenetic aging in the blood as potential breast cancer marker

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) on December 5, 2024, Volume 16, Issue 22, titled "DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility."

21 Jan 2025

Automated technology streamlines astatine-211 production for cancer therapy

Astatine-211 (At-211) is one of a handful of promising alpha emitting radioisotopes for cancer therapy.

20 Jan 2025

Exploring the use of genomic classifier tests in prostate cancer risk stratification

A systematic review found that while genomic classifier (GC) tests may influence risk classifications or treatment decisions for patients with localized prostate cancer (PCa), there is a need for better data on their cost-effectiveness, clinical utility, and their impact on racial and ethnic groups, particularly Black men.

20 Jan 2025

Study reveals how children's immune systems react to cancer

Researchers at Karolinska Institutet and the Astrid Lindgren Children's Hospital in Sweden have determined how children's immune systems react to different kinds of cancer depending on their age.

20 Jan 2025