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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Disrupting ChIP Assay Technology with New Advancements

The Chromatrap ChIP technology is a bead-free method of performing ChIP. The potential of the technology emerged from our capabilities in manufacturing porous plastic filters for the filtration and separation of biological materials.

From Chromatrap® - Porvair Sciences Ltd 27 Jun 2019

Compelling New Evidence Further Suggests Parkinson’s Disease Begins in the Gut

A new mouse study has revealed more evidence that Parkinson’s disease originates in the gut before traveling to the brain via the body’s neurons.

27 Jun 2019

Scientists reveal mechanism of tumor metastasis and tumor-suppressive role of UDP-glucose

Scientists from Dalian Institute of Chemical Physics and Shanghai Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences revealed that UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis.

27 Jun 2019

Scientists suggest possible cell-based therapy for premature infants with rare lung condition

Researchers suggest a possible cell-based therapy to stimulate lung development in fragile premature infants who suffer from a rare condition called Bronchopulmonary Dysplasia, which in the most severe cases can lead to lifelong breathing problems and even death.

27 Jun 2019

A metabolic intermediate in the uronic acid pathway impairs lung cancer metastasis

In a study published online in Nature on June 26, research teams led by Dr. YANG Weiwei at the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences and Dr. LI Guohui from the Dalian Institute of Chemical Physics of CAS reported a new function of uridine diphosphate glucose (UDP-glucose), a metabolic intermediate in the uronic acid pathway: It impairs lung cancer metastasis by accelerating SNAI1 mRNA decay.

27 Jun 2019

Cascade aggravates hereditary storage diseases

In rare, hereditary storage diseases such as Sandhoff's disease or Tay-Sachs syndrome, the metabolic waste from accumulating gangliosides cannot be properly disposed of in the nerve cells because important enzymes are missing.

26 Jun 2019

How an orchestra of neurons control hunger pangs

A new study has shown that multiple neurons within the brain come together to regulate the need to eat and feeling of fullness, or satiety.

26 Jun 2019

Researchers challenge conventional understanding of cause of Parkinson's

An international team of researchers involving members of the University of Basel's Biozentrum challenges the conventional understanding of the cause of Parkinson's disease.

26 Jun 2019

Study reveals dual effects of new osteoporosis therapy on bone tissue

Sclerostin is a protein produced by osteocytes in the bone that inhibits bone formation. A recent analysis of results from a clinical trial reveals the beneficial effects of romosozumab, an antibody therapy that targets sclerostin, on bone tissue in postmenopausal women with osteoporosis.

26 Jun 2019

ELISA test performed in 3D-printed pipette tips simplifies process, reduces cost

Scientists have taken a common, yet laborious lab test and redesigned it to be performed in small 3D printed pipette tips used to measure and transfer fluids in the laboratory.

26 Jun 2019

Using Light Scattering to Characterize Protein-Nucleic Acid Interactions

Harnessing the interactions between DNA, RNA, and proteins holds much promise for detecting biomarkers, diagnosing disease, and improving cancer-targeting therapeutics. Quantifying these interactions is essential for understanding and controlling their biomolecular mechanisms.

From Waters | Wyatt Technology 26 Jun 2019

Stability Testing of Therapeutic Proteins using DLS and Machine Learning

PIPPI scientists from different fields are developing methodologies, tools, and databases to guide the rational formulation of robust protein-based therapeutics. Their overall goal is to develop a database to guide product formulation development.

From Waters | Wyatt Technology 26 Jun 2019

Measuring blood protein levels in diabetic patients to predict risk of stroke

Having diabetes is a risk factor for many other health conditions, including stroke.

26 Jun 2019

Study discusses beneficial effects of antibody therapy that targets sclerostin

26 Jun 2019

Study shows how gastric stem cells fight colonizing bacteria

Stem cells are not only key players in tissue regeneration, they are also capable of taking direct action against bacteria.

25 Jun 2019

Researchers develop simple blood test for detecting Alzheimer’s disease

Researchers from Lund University, together with the Roche pharmaceutical company, have used a method to develop a new blood marker capable of detecting whether or not a person has Alzheimer's disease.

25 Jun 2019

Coffee may boost weight loss, concludes study

Coffee has been shown to increase the release of heat from brown fat, potentially boosting weight loss efforts.

25 Jun 2019

Researchers reveal fundamental role of protein associated with Alzheimer's

Researchers from the University of Seville, the Seville Biomedicine Institute and Lund University have been able to describe how the body responds to a component present in the brain in Alzheimer's patients.

25 Jun 2019

Promising new technique for high throughput protein purification

Postnova Analytics has published an application report that describes a promising new protein purification technique based on diffusion.

From Postnova Analytics 25 Jun 2019

PhoreMost and C4XD sign neurodegeneration drug discovery collaboration agreement

PhoreMost Limited, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, and C4X Discovery Holdings plc, a pioneering drug discovery company, today announced they have signed a neurodegeneration drug discovery collaboration agreement.

From PhoreMost 25 Jun 2019