Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

New drug targeting genetic weakness could become first treatment for childhood brain cancer

A new type of drug that targets a genetic weakness in an untreatable childhood brain cancer could become the first ever treatment designed to target the disease.

9 May 2019

Small molecule drug may help overcome ibrutinib resistance in mantle cell lymphona

A study at The University of Texas MD Anderson Cancer Center demonstrated how a small molecule drug discovered at the institution may help overcome resistance to treatment with ibrutinib in patients with mantle cell lymphoma.

9 May 2019

Aptamer Therapeutics collaborates with Cancer Research UK for drug development program

Following the successful awarding of a CRUK Biotherapeutic Drug Discovery Project Award, Aptamer Therapeutics Limited, part of Aptamer Group, is pleased to announce a new collaboration with Dan Wiseman and the Oglesby Leukemia Research Program at the University of Manchester and Cancer Research UK.

From Aptamer Group 6 May 2019

New HKBU method could lead to the production of higher quality medicinal drugs

Physics and Chemistry scholars from Hong Kong Baptist University (HKBU) have invented a new method which could speed up the drug discovery process and lead to the production of higher quality medicinal drugs which are purer and have no side effects.

29 Apr 2019

New chemical synthesis strategy leads to identification of novel, simpler derivatives

A new chemical synthesis strategy to harvest the rich information found in natural products -- organic compounds isolated from natural sources -- has led to the identification of novel, simpler derivatives with potential to selectively protect neurons, important for neurodegenerative diseases like Alzheimer's disease, or to prevent the immune system from rejecting organ transplants, according to a Baylor University-led study.

25 Apr 2019

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania talks to News-Medical and Life Sciences about the importance of light scattering techniques for investigating structure and mechanism of action in his ongoing research into HIV integrase and the development of HIV therapeutics.

From Waters | Wyatt Technology 24 Apr 2019

Scientists identify 104 high-risk genes for schizophrenia

Using a unique computational "framework" they developed, a team of scientist cyber-sleuths in the Vanderbilt University Department of Molecular Physiology and Biophysics and the Vanderbilt Genetics Institute has identified 104 high-risk genes for schizophrenia.

23 Apr 2019

New discovery transforms conventional microfluidics into open-space microfluidics

Microfluidics refers to the manipulation of fluids in microscale devices. Commonly called "labs on a chip," microfluidic systems are used to study and analyze very small-scale chemical or biological samples, replacing the extremely expensive and cumbersome instruments used for traditional biological analyses.

19 Apr 2019

Scientists enter research collaboration to find a cure for cancer

Cancer is a disease that afflicts an alarming number of people, with one in two being diagnosed with a type of cancer during their lifetime.

17 Apr 2019

Researchers create new small molecules that may combat equine encephalitis viruses

Viruses without a preventative vaccine or treatment option pose a looming threat. But for viruses in this category that have already been weaponized and are recognized as human biothreats by the Centers for Disease Control and Prevention, it's a race to find a cure.

17 Apr 2019

Using slime mold to produce accessible biosensors

An EU-funded project is using slime mold to produce accessible sensing devices with a wide range of applications, including environmental monitoring and health - helping European industry become more competitive in the growing biosensor device market.

15 Apr 2019

Biomolecular researcher provides comprehensive profile of B cells in rheumatoid arthritis

Biomolecular researcher Navin Varadarajan has published in Arthritis & Rheumatology journal a first-of-its-kind study - a comprehensive profile of B cells in rheumatoid arthritis.

12 Apr 2019

Study describes vulnerability shared by large subset of cancer cell lines

Cancer cells adapt to potentially fatal mutations and other molecular malfunctions by adjusting one or more other genes' activity, in the process becoming dependent on those genes for their survival and growth.

12 Apr 2019

USC researchers report breakthrough to prevent osteonecrosis of the jaw

USC researchers and collaborators report a breakthrough to prevent damage to the jaw, a side effect suffered by some people undergoing treatment for cancer or osteoporosis.

11 Apr 2019

GARDP forms multi-actor partnerships to discover new antibiotics

Multi-actor partnership tests natural products and compound libraries for antibacterial activity Discovery efforts will focus on World Health Organization's priority pathogens The Global Antibiotic Research and Development Partnership is partnering with Calibr, the Helmholtz Centre for Infection Research, in particular its location Helmholtz-Institute for Pharmaceutical Research Saarland, and the University of Queensland's Community for Open Antimicrobial Drug Discovery in its efforts to develop and ensure new antibiotics are globally available to all patients who need them.

11 Apr 2019

Pittcon 2019 in Philadelphia proves successful

Pittcon 2019, the 70th annual conference and exposition for analytical chemistry and applied spectroscopy, saw an increase in attendance over last year’s Orlando event.

From Pittcon 11 Apr 2019

Bruker highlights innovative NMR capabilities and products at ENC 2019

At ENC 2019, Bruker highlights innovative NMR capabilities and products for biomolecular, materials research and pharmaceutical applications, as well as new scientific software solutions.

From Bruker BioSpin Group 10 Apr 2019

Researchers aim to identify potential new drugs for wide range of diseases using AI

A half dozen University of Connecticut researchers are now working to identify potential new drugs to treat a wide range of diseases and conditions through a unique partnership that offers access to cutting-edge artificial intelligence technology and screening compounds at no cost.

10 Apr 2019

UTMB receives grant to combat highly-lethal hemorrhagic fever viruses

The University of Texas Medical Branch at Galveston, Profectus Biosciences, Vanderbilt University Medical Center, Mapp Biopharmaceutical and Genevant Sciences Corp. have been awarded up to $35 million to advance the development of rapid-acting vaccines and broad-spectrum treatments of the highly-lethal hemorrhagic fever viruses Ebola and Marburg.

9 Apr 2019

New clinical trials to investigate combination immunotherapy for treating advanced cancers

City of Hope physician-scientists recently opened two clinical trials to investigate a combination of cytokines and immunotherapy that may be able to transform nearly-impossible-to-treat cancer into a disease that can be corralled into remission.

8 Apr 2019

Drug Discovery News and Research

Further Reading

New drug targeting genetic weakness could become first treatment for childhood brain cancer

Small molecule drug may help overcome ibrutinib resistance in mantle cell lymphona

Aptamer Therapeutics collaborates with Cancer Research UK for drug development program

New HKBU method could lead to the production of higher quality medicinal drugs

New chemical synthesis strategy leads to identification of novel, simpler derivatives

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

Scientists identify 104 high-risk genes for schizophrenia

New discovery transforms conventional microfluidics into open-space microfluidics

Scientists enter research collaboration to find a cure for cancer

Researchers create new small molecules that may combat equine encephalitis viruses

Using slime mold to produce accessible biosensors

Biomolecular researcher provides comprehensive profile of B cells in rheumatoid arthritis

Study describes vulnerability shared by large subset of cancer cell lines

USC researchers report breakthrough to prevent osteonecrosis of the jaw

GARDP forms multi-actor partnerships to discover new antibiotics

Pittcon 2019 in Philadelphia proves successful

Bruker highlights innovative NMR capabilities and products at ENC 2019

Researchers aim to identify potential new drugs for wide range of diseases using AI

UTMB receives grant to combat highly-lethal hemorrhagic fever viruses

New clinical trials to investigate combination immunotherapy for treating advanced cancers

eBook: Image-guided automated cell culture for 2D, iPSC, and organoid workflows eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo