Crystallography News and Research

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World's first fully reversible manipulation of the circadian clock

The Nagoya University Institute of Transformative Bio-Molecules research team of Designated Associate Professor Tsuyoshi Hirota, Postdoctoral Fellow Simon Miller, Professor Kenichiro Itami and graduate student Tsuyoshi Oshima (Research Fellowship for Young Scientists, JSPS), in collaboration with the group of Professor Ben Feringa and Postdoctoral Fellow Dušan Kolarski of Groningen University in the Netherlands, have achieved a world first: fully reversible manipulation of the period of the circadian clock using light, by exchanging part of a compound with a light-activated switch.

25 Jan 2021

Scientists uncover elusive mechanism behind the most severe cases of blood disorder

With a name like glucose-6-phosphate dehydrogenase deficiency, one would think it is a rare and obscure medical condition, but that's far from the truth.

19 Jan 2021

Study improves understanding of the chemistry behind potent antibiotic synthesis

Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic's synthesis.

18 Jan 2021

Study reports promising new monoclonal antibody against SARS-CoV-2’s spike protein

An encouraging new study describes a promising new therapeutic antibody that shows potent neutralizing activity against SARS-CoV-2, the causative agent of COVID-19.

15 Jan 2021

New UK-derived SARS-CoV-2 variant does not affect neutralizing antibodies efficiency, study says

A team of scientists conducted structural analysis of a newly emerged UK variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They present evidence that suggests that while the new variant has increased infectivity it is not resistant to neutralizing antibodies.

13 Jan 2021

New results help understand biological phenomena mediated by cell membrane integrin receptors

Researchers at Tampere University, Finland, have published new results in collaboration with an international research network that help to understand the biological phenomena mediated by cell membrane integrin receptors and contribute to the development of methods for the treatment of cancer.

13 Jan 2021

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

12 Jan 2021

Scientists decipher the structure of protein found in parasites that cause neglected tropical diseases

Brazilian researchers have managed to decipher the structure of a protein found in parasites that cause neglected tropical diseases, paving the way to the development of novel medications.

8 Jan 2021

Study shows how sodium ions drive glutamate transport in the central nervous system

Scientists from the MIPT Research Center for Molecular Mechanisms of Aging and Age-Related Diseases have joined forces with their colleagues from Forschungszentrum Jülich, Germany, and uncovered how sodium ions drive glutamate transport in the central nervous system.

22 Dec 2020

Multidisciplinary research sheds new light on reaction mechanisms in cellular processes

Multidisciplinary research involving crystallography, kinetic studies, molecular docking, genetics and other techniques in biochemistry has yielded a wealth of knowledge about the reaction mechanisms in cellular processes.

1 Dec 2020

Researchers identify acrylamides that inhibit SARS-CoV-2 main protease

A new study in the preprint server bioRxiv published in November 2020 describes the discovery of acrylamide fragments that can effectively disable key enzymes in both the hand, foot and mouth virus and SARS-CoV-2 virus.

11 Nov 2020

Study shows dexamethasone can reduce chance of COVID-19-related death

Research has shown that dexamethasone, a widely available steroid, can significantly reduce the chance of death from COVID-19.

10 Nov 2020

New strategy for designing COVID-19 antiviral drugs to inhibit key viral protein

SARS-CoV-2, the respiratory virus that causes COVID-19, attacks the body in multiple steps. Gaining entry into cells deep within the lungs and hijacking the human host cell's machinery to churn out copies of itself are two of the earliest steps -- both essential for viral infection.

9 Nov 2020

APS technique shows how SARS-CoV-2 virus camouflages itself inside the human body

Scientists using the Advanced Photon Source have discovered new insights into the ways the SARS-CoV-2 virus camouflages itself inside the human body.

30 Oct 2020

Researchers demonstrate potent antibody that fights against coronavirus

Scientists at Fred Hutchinson Cancer Research Center in Seattle have shown that a potent antibody from a COVID-19 survivor interferes with a key feature on the surface of the coronavirus's distinctive spikes and induces critical pieces of those spikes to break off in the process.

28 Oct 2020

Scientists design 3D map to understand the behavior of novel coronavirus

To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.

28 Oct 2020

Scientists lay out a novel rationale for COVID-19 drug design

American and Polish scientists, reporting Oct. 16 in the journal Science Advances, laid out a novel rationale for COVID-19 drug design - blocking a molecular "scissor" that the virus uses for virus production and to disable human proteins crucial to the immune response.

19 Oct 2020

Molecular stilts help deadly parasites to invade host cells

In biological terms, gliding refers to the type of movement during which a cell moves along a surface without changing its shape. This form of movement is unique to parasites from the phylum Apicomplexa, such as Plasmodium and Toxoplasma.

13 Oct 2020

New approach to reveal high-resolution protein structural details

The number of proteins in the human body, collectively known as the proteome, is vast. Somewhere between 80,000 and 400,000 proteins circulate in our cells, tissues and organs, carrying out a broad range of duties essential for life.

6 Oct 2020

Crystallography News and Research

World's first fully reversible manipulation of the circadian clock

Scientists uncover elusive mechanism behind the most severe cases of blood disorder

Study improves understanding of the chemistry behind potent antibiotic synthesis

Study reports promising new monoclonal antibody against SARS-CoV-2’s spike protein

New UK-derived SARS-CoV-2 variant does not affect neutralizing antibodies efficiency, study says

New results help understand biological phenomena mediated by cell membrane integrin receptors

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

Scientists decipher the structure of protein found in parasites that cause neglected tropical diseases

Study shows how sodium ions drive glutamate transport in the central nervous system

Multidisciplinary research sheds new light on reaction mechanisms in cellular processes

Researchers identify acrylamides that inhibit SARS-CoV-2 main protease

Study shows dexamethasone can reduce chance of COVID-19-related death

New strategy for designing COVID-19 antiviral drugs to inhibit key viral protein

APS technique shows how SARS-CoV-2 virus camouflages itself inside the human body

Researchers demonstrate potent antibody that fights against coronavirus

Scientists design 3D map to understand the behavior of novel coronavirus

Scientists lay out a novel rationale for COVID-19 drug design

Molecular stilts help deadly parasites to invade host cells

New approach to reveal high-resolution protein structural details

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