Neurodegenerative Diseases News and Research

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Diesel exhaust particles can impair microglial functions

Diesel exhaust particles can disturb the function of human brain immune cells, known as microglia, according to a recent study led by the University of Eastern Finland.

25 Nov 2025

Scientists uncover how brain enzyme OTULIN controls tau expression

Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease.

25 Nov 2025

Can diet calm early memory problems? Anti-inflammatory Mediterranean eating shows promise

Older women who follow a strongly anti-inflammatory Mediterranean diet report far fewer subjective memory complaints than those who do not. The AnMED pattern outperforms both traditional Mediterranean and MIND diets, showing a clear advantage for protecting early cognitive symptoms.

24 Nov 2025

Does coffee truly boost memory and focus or is it all hype?

Coffee’s bioactive compounds, especially caffeine, show potential cognitive, neuroprotective, and neuroplasticity benefits across animal and human studies. However, most findings are observational, mechanisms remain uncertain, and optimal intake is still unclear.

23 Nov 2025

Oral arginine reduces amyloid buildup in Alzheimer’s models

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is one of the leading causes of dementia worldwide, and currently has no definitive cure. Although antibody-based therapies that target amyloid β (Aβ) have recently been developed, their clinical effectiveness remains limited.

21 Nov 2025

Study clarifies how spermine can guard against Alzheimer’s and Parkinson’s

Researchers at the Paul Scherrer Institute PSI have clarified how spermine - a small molecule that regulates many processes in the body's cells - can guard against diseases such as Alzheimer's and Parkinson's: it renders certain proteins harmless by acting a bit like cheese on noodles, making them clump together.

21 Nov 2025

Astrocyte-driven approach shows potential to reverse cognitive decline in Alzheimer’s

Researchers at Baylor College of Medicine have discovered a natural mechanism that clears existing amyloid plaques in the brains of mouse models of Alzheimer's disease and preserves cognitive function.

21 Nov 2025

Study reveals how aging reshapes protein chemistry in the brain

A study by the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena shows that the chemical composition of proteins in the brain undergoes fundamental changes with aging.

20 Nov 2025

Muscle-driven gene therapy shows promise for protecting memory in Alzheimer’s

Alzheimer's disease (AD) is a devastating cause of memory loss and cognitive decline, for which no curative treatment is available.

18 Nov 2025

Polymer physics offers fresh perspectives on neurodegenerative diseases

Researchers from Tokyo Metropolitan University have applied ideas from polymer physics to illuminate the mechanism behind a key pathology in Alzheimer's disease, the formation of fibrils of tau proteins.

17 Nov 2025

Preclinical study shows aged garlic extract improves memory and reduces anxiety

Long-term aged garlic extract supplementation improved specific anxiety-related behaviors and enhanced memory and learning in aging mice. Proteomic profiling revealed extensive hippocampal and cortical molecular changes linked to synaptic signaling, neuroplasticity, and stress-response pathways.

16 Nov 2025

TRIMTECH Therapeutics appoints Dr Mike Hutton to Scientific Advisory Board

TRIMTECH Therapeutics, a biotech company creating novel, small molecule therapeutics that selectively degrade protein aggregates, to combat neurodegenerative diseases, today announced the appointment of Dr Mike Hutton to its Scientific Advisory Board (SAB).

From TRIMTECH Therapeutics 12 Nov 2025

What the air you breathe may be doing to your brain

For years, the two patients had come to the Penn Memory Center at the University of Pennsylvania, where doctors and researchers follow people with cognitive impairment as they age, as well as a group with normal cognition.

12 Nov 2025

Stress-induced neuron loss shown to disrupt blood flow and neural communication

While the exact causes of neurodegenerative brain diseases like Alzheimer's and dementia are still largely unknown, researchers have been able to identify a key characteristic in affected brains: reduced blood flow.

11 Nov 2025

Midlife blood test may reveal Alzheimer’s disease risk in advance

A simple blood test for platelet activity at middle age could one day help identify people at risk for Alzheimer's disease decades ahead of time, allowing for possible preventive therapy.

11 Nov 2025

Targeting RNA splicing errors protects against tau-induced neurodegeneration

Alzheimer's Disease (AD), the leading cause of dementia, affects nearly 40 million individuals globally, resulting in a gradual loss of memory and independence. Despite extensive research over the past decades, no treatments have been found that can halt or reverse the progression of this devastating disease.

11 Nov 2025

Scientists pinpoint a reason Alzheimer’s patients forget loved ones

One of the most devastating moments for family members of a patient with Alzheimer's is when their loved one forgets who they are. New University of Virginia School of Medicine research may explain why that happens and could lead to a way to prevent it.

10 Nov 2025

Harnessing nanotechnology to deliver CBD to the brain for neuropathic pain relief

Reaching for CBD-infused lotion or oil may seem like a low-risk way to find pain relief, but little is actually known about the impact that CBD has on the nervous system.

7 Nov 2025

Low-dose THC mitigates harmful side effects and inflammation caused by HIV treatment

Long-term, low doses of THC mitigate many harmful side effects and inflammation caused by HIV and antiretroviral therapy (ART), according to new research from Texas Biomedical Research Institute.

6 Nov 2025

Scientists map kinesin-2 tail structure to understand cargo binding

For decades, scientists have known that motor proteins like kinesin-2 ferry vital cargo along microtubule "highways" inside cells. But how these molecular vehicles identify and bind to the right cargo remained a mystery. The new study provides a key piece of this puzzle by revealing the atomic-level structure of the kinesin-2 tail and its interaction with cargo and adaptor proteins.

6 Nov 2025