Oncology News and Research

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Oncology, meaning bulk, mass, or tumor, and the suffix ''-logy'', meaning "study of") is a branch of medicine that deals with tumors (cancer). A medical professional who practices oncology is an ''oncologist''.

Study could pave the way for synergistic therapeutic combinations to better treat SF3B1-mutant MDS

A new study from researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations provides insight into the underlying mechanisms of gene mutations commonly seen in patients with myelodysplastic syndromes (MDS) and other myeloid neoplasms.

11 Dec 2023

Combination of dasatinib and blinatumomab offers effective treatment for older Ph+ ALL patients

Older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who were not good candidates for the standard treatment of intensive chemotherapy had a median overall survival (OS) of 6.5 years on an alternate regimen of dasatinib and blinatumomab.

11 Dec 2023

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

Early results from a Phase I clinical trial of AT101, a new CAR T cell therapy that uses a distinct binding mechanism to target CD19, show a 100 percent complete response (CR) rate at the higher dose levels studied in the trial, according to researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine's Abramson Cancer Center.

11 Dec 2023

New organoid model could revolutionize neuroendocrine tumor research

The Organoid Group (Hubrecht Institute) and the Rare Cancers Genomics Team (IARC/WHO) found a way to grow samples of different types of neuroendocrine tumors (NETs) in the lab.

11 Dec 2023

Natural compound activates macrophages to fight resistant tuberculosis bacteria

Tuberculosis (TB) is a prevalent infectious disease that affects millions of people each year. It was previously the leading cause of death from a single pathogen before the COVID-19 pandemic.

11 Dec 2023

ChatGPT models excel in neurology exam, surpassing human student performance

Study shows two ChatGPT large language models (LLMs) outperformed human neurology students in an entrance exam, with one model achieving 85% accuracy, demonstrating their potential in clinical neurology and medical education.

10 Dec 2023

Low-risk DCIS patients may safely skip radiotherapy after surgery, study finds

Patients with low-risk ductal carcinoma in situ (DCIS) who skipped adjuvant radiotherapy after breast-conserving surgery had comparable five-year outcomes to those with high-risk DCIS who received adjuvant radiotherapy, according to results from the E4112 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

8 Dec 2023

MD Anderson and Rigel partner to expand olutasidenib evaluation in AML and other cancers

The University of Texas MD Anderson Cancer Center and Rigel Pharmaceuticals, Inc. today announced a multi-year strategic development collaboration to expand the evaluation of olutasidenib in acute myeloid leukemia (AML) and other hematologic cancers.

8 Dec 2023

Study identifies targetable fusion RNAs in breast cancer

Comprehensive profiling of fusion RNAs present in a large cohort of metastatic breast tumors revealed unique fusion mutations that may be therapeutically targetable, according to results presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

8 Dec 2023

Women undergoing chemotherapy may not benefit from common fertility protection drug

A new study from Karolinska Institutet in Sweden has found no evidence that a common drug used to protect the ovaries of women undergoing chemotherapy increases their chances of having children after cancer treatment.

8 Dec 2023

Exploring the role of liquid biopsies in early-stage prostate cancer

A new research perspective was published in Oncoscience (Volume 10) on November 30, 2023, entitled, "Evolving insights in blood-based liquid biopsies for prostate cancer interrogation."

8 Dec 2023

T cells can recognize and fight the "Pirola" variant, new study suggests

In August, researchers detected a new SARS-CoV-2 "variant of concern" in patients in Israel and Denmark.

8 Dec 2023

A class of diabetes medications may reduce the risk of colorectal cancer

A groundbreaking study by researchers at Case Western Reserve University suggests a class of medications used to treat type 2 diabetes may also reduce the risk of colorectal cancer (CRC).

7 Dec 2023

Anastrozole efficacy in breast cancer prevention for high-risk women linked to estrogen levels

Study examines the efficacy of anastrozole in preventing breast cancer in postmenopausal women at high risk, focusing on the role of baseline estradiol levels and their impact on treatment outcomes.

7 Dec 2023

Study underscores need for primary prevention in advanced breast cancer

While regular screenings may decrease the chance of diagnosis of advanced breast cancer in some women and lead to a 20% reduction in breast cancer mortality, other women will be diagnosed with advanced breast cancer despite screening at regular intervals.

7 Dec 2023

Breakthrough discovery paves the way for new methods to detect and treat leukemia

Researchers led by François Fuks - Laboratory of Cancer Epigenetics, ULB Faculty of Medicine, ULB Cancer Research Center and Jules Bordet Institute, H.U.B. - have made a major breakthrough in the understanding and treatment of leukemia.

7 Dec 2023

IDEA trial: Skipping radiotherapy safe for younger postmenopausal patients with early-stage breast cancer

Almost all postmenopausal patients aged 50-69 years with stage I hormone receptor (HR)-positive breast cancer and low scores on a common genetic test who opted out of adjuvant radiotherapy were disease free five years after surgery, according to results from the IDEA clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

7 Dec 2023

Blocking an allergy pathway unleashes antitumor immunity in mouse models of non-small cell lung cancer

Researchers at the Icahn School of Medicine at Mount Sinai have identified an allergy pathway that, when blocked, unleashes antitumor immunity in mouse models of non-small cell lung cancer (NSCLC).

6 Dec 2023

New drug combo fights breast cancer with brain metastases

A combination of two HER2-targeted drugs, tucatinib (Tukysa) and trastuzumab emtansine (Kadcyla, T-DM1), extended progression-free survival among patients with unresectable locally advanced or metastatic HER2-positive breast cancer, compared with T-DM1 alone, according to results from the HER2CLIMB-02 trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

6 Dec 2023

Neoadjuvant chemotherapy can eliminate need for regional nodal irradiation in breast cancer

For patients whose breast cancer converted from lymph node-positive to lymph node-negative disease after neoadjuvant chemotherapy, skipping adjuvant regional nodal irradiation (RNI) did not increase the risk of disease recurrence or death five years after surgery, according to results from the NRG Oncology/NSABP B-51/RTOG 1304 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

6 Dec 2023

Oncology News and Research

Further Reading

Study could pave the way for synergistic therapeutic combinations to better treat SF3B1-mutant MDS

Combination of dasatinib and blinatumomab offers effective treatment for older Ph+ ALL patients

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

New organoid model could revolutionize neuroendocrine tumor research

Natural compound activates macrophages to fight resistant tuberculosis bacteria

ChatGPT models excel in neurology exam, surpassing human student performance

Low-risk DCIS patients may safely skip radiotherapy after surgery, study finds

MD Anderson and Rigel partner to expand olutasidenib evaluation in AML and other cancers

Study identifies targetable fusion RNAs in breast cancer

Women undergoing chemotherapy may not benefit from common fertility protection drug

Exploring the role of liquid biopsies in early-stage prostate cancer

T cells can recognize and fight the "Pirola" variant, new study suggests

A class of diabetes medications may reduce the risk of colorectal cancer

Anastrozole efficacy in breast cancer prevention for high-risk women linked to estrogen levels

Study underscores need for primary prevention in advanced breast cancer

Breakthrough discovery paves the way for new methods to detect and treat leukemia

IDEA trial: Skipping radiotherapy safe for younger postmenopausal patients with early-stage breast cancer

Blocking an allergy pathway unleashes antitumor immunity in mouse models of non-small cell lung cancer

New drug combo fights breast cancer with brain metastases

Neoadjuvant chemotherapy can eliminate need for regional nodal irradiation in breast cancer

Event guide: 10th CAR-TCR Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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