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Already approved drug avapritinib shows promise in treating high-grade gliomas

High-grade glioma, an aggressive form of pediatric and adult brain cancer, is challenging to treat given the tumor location, incidence of recurrence and difficulty for drugs to cross the blood-brain barrier.

13 Mar 2025

MIT engineers develop efficient method to convert skin cells into neurons

Converting one type of cell to another - for example, a skin cell to a neuron - can be done through a process that requires the skin cell to be induced into a "pluripotent" stem cell, then differentiated into a neuron.

13 Mar 2025

CRISPR technologies paving the way for advances in regenerative medicine

A recent review published in the journal Engineering delves into the significant advancements and potential of CRISPR technologies in the field of regenerative medicine.

13 Mar 2025

Researchers discover race-associated molecular differences in pancreatic tumors

Researchers have discovered race-associated molecular differences in tumors that may impact the way patients with pancreatic cancer respond to immunotherapies.

12 Mar 2025

Researchers uncover 195 genetic risk factors driving women’s reproductive diseases

Scientists identified 195 genetic risk loci across 42 female reproductive health conditions, revealing shared genetic pathways and developing a polygenic risk score for intrahepatic cholestasis of pregnancy (ICP). These findings pave the way for personalized reproductive healthcare and targeted treatments based on genetic risk.

12 Mar 2025

People from families with exceptional longevity have lower risk of peripheral artery disease

A new research paper was published in Aging (Aging-US) on February 25, 2025, Volume 17, Issue 2, titled "Epidemiology and genetic determination of measures of peripheral vascular health in the Long Life Family Study."

12 Mar 2025

New malaria control strategy targets protein system in mosquitoes

A molecular quality-control system in Anopheles mosquitoes-the species responsible for most of the world's malaria cases-is a promising target for future malaria-control strategies, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

11 Mar 2025

Study identifies genetic changes in blood stem cells of frequent blood donors

Researchers at the Francis Crick Institute have identified genetic changes in blood stem cells from frequent blood donors that support the production of new, non-cancerous cells.

11 Mar 2025

Environmental factors and genes play key role in cancer development

A new editorial was published in Oncotarget, Volume 16, on March 10, 2025, titled "EXPOSOMES and GENES: The duo influencing CANCER initiation and progression."

11 Mar 2025

Maternal cannabis use disorder linked to increased risk of child behavioral disorders

Researchers determine how maternal cannabis use disorder during and after pregnancy impacts the child’s behavior.

11 Mar 2025

Novel regulators in digestive tract disease progression and treatment

This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive tract diseases, positioning these molecules as potential biomarkers for diagnosis, prognosis, and targeted therapies. The comprehensive review explores the biogenesis, classification, and biological functions of tsRNAs, shedding light on their influence over cellular processes such as translation regulation, epigenetic modification, and protein interactions.

11 Mar 2025

Study reveals the role of transcription factors as therapeutic gateways in MAFLD

Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions worldwide. This complex liver disorder ranges from simple steatosis to more severe forms, including metabolic dysfunction-associated steatohepatitis (MASH), which may progress to fibrosis, cirrhosis, and even liver cancer.

11 Mar 2025

Decoding programmed cell death in breast cancer

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC remains a significant global health challenge.

11 Mar 2025

Study highlights the role of ELF4 as a key transcription factor in development, immunity, and oncology

ELF4, a transcription factor belonging to the ETS family, has emerged as a pivotal regulator in cell differentiation, immune system function, and cancer progression. This newly published review underscores its molecular complexity and clinical significance, shedding light on its dual role in tumor suppression and oncogenesis.

11 Mar 2025

Deciphering the tumor-immune interplay in endometrial carcinoma

A new review article published in Genes & Diseases sheds light on the complex molecular mechanisms through which tumor-infiltrating immune cells regulate endometrial carcinoma (EC). As one of the most prevalent gynecological cancers, EC continues to challenge researchers and clinicians due to its dynamic interaction with the immune microenvironment.

11 Mar 2025

Study reveals TCM-Based strategies for ferroptosis modulation

Innovative insights into the role of ferroptosis, a unique form of programmed cell death, are reshaping the landscape of disease treatment. This growing field highlights how Traditional Chinese Medicine (TCM) can effectively modulate ferroptosis, offering novel therapeutic approaches for various conditions, including cancer, cardiovascular diseases, neurodegenerative disorders, and organ injuries.

11 Mar 2025

Harnessing lncRNAs for early diagnosis and intervention in acute kidney injury

A new review published in Genes & Diseases on long non-coding RNAs (lncRNAs) highlights their critical role in the development, diagnosis, and potential treatment of acute kidney injury (AKI) and chronic kidney disease (CKD). The findings emphasize the importance of exosomal lncRNAs, which function as molecular regulators in kidney pathology and hold promise for future biomarker discovery and therapeutic advancements.

11 Mar 2025

Ovarian cancer mutations across populations show similarities and unique differences

An extensive tumor genomic analysis of individuals with ovarian cancer, led by researchers from Huntsman Cancer Institute at the University of Utah (the U) and Emory University, revealed that Black women have nearly identical mutations to other previously studied populations.

10 Mar 2025

Platelet-rich plasma may enhance ovarian rejuvenation and improve egg quality in women

A new research paper was published in Aging (Aging-US) on February 18, 2025, Volume 17, Issue 2, titled "Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP)."

10 Mar 2025

Combination of Epstein-Barr virus antibodies and genes linked to increased risk of MS

In multiple sclerosis (MS), antibodies to the common Epstein-Barr virus can accidentally attack a protein in the brain and spinal cord. New research shows that the combination of certain viral antibodies and genetic risk factors can be linked to a greatly increased risk of MS.

10 Mar 2025

Genes News and Research

Already approved drug avapritinib shows promise in treating high-grade gliomas

MIT engineers develop efficient method to convert skin cells into neurons

CRISPR technologies paving the way for advances in regenerative medicine

Researchers discover race-associated molecular differences in pancreatic tumors

Researchers uncover 195 genetic risk factors driving women’s reproductive diseases

People from families with exceptional longevity have lower risk of peripheral artery disease

New malaria control strategy targets protein system in mosquitoes

Study identifies genetic changes in blood stem cells of frequent blood donors

Environmental factors and genes play key role in cancer development

Maternal cannabis use disorder linked to increased risk of child behavioral disorders

Novel regulators in digestive tract disease progression and treatment

Study reveals the role of transcription factors as therapeutic gateways in MAFLD

Decoding programmed cell death in breast cancer

Study highlights the role of ELF4 as a key transcription factor in development, immunity, and oncology

Deciphering the tumor-immune interplay in endometrial carcinoma

Study reveals TCM-Based strategies for ferroptosis modulation

Harnessing lncRNAs for early diagnosis and intervention in acute kidney injury

Ovarian cancer mutations across populations show similarities and unique differences

Platelet-rich plasma may enhance ovarian rejuvenation and improve egg quality in women

Combination of Epstein-Barr virus antibodies and genes linked to increased risk of MS

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