Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Age-related increases in brain inflammation may link Alzheimer's disease risk with sleep disturbance

A multisite research team from the University of California, Irvine, the University of Wisconsin–Madison and Wake Forest University has discovered that brain inflammation may link Alzheimer's disease risk with sleep disturbance, which may aid early detection and prevention efforts by identifying novel treatment targets at preclinical stages.

13 Jul 2022

Prion imaging could lead to better understanding of what causes fatal neurological disorders

Prion diseases are incurable, deadly neurological disorders that can affect both humans and animals–including Creutzfeldt-Jakob Disease (CJD) in people, Bovine Spongiform Encephalopathy (also known as Mad Cow Disease) and Chronic Wasting Disease found in deer.

13 Jul 2022

Surveillance program for high risk patients aids in early detection of pancreatic cancer

Surveillance programs for people at high risk of developing pancreatic cancers can help detect precancerous conditions and cancers early, when they are most treatable, according to a new multicenter study directed by experts at the Johns Hopkins Kimmel Cancer Center.

13 Jul 2022

Study reveals a specific metabolic adaptation in some patients with acute myeloid leukemia

An article published in the journal Nature Communications describes a specific metabolic adaptation in some patients with acute myeloid leukemia affected by tandem mutations in the FLT3 gene.

13 Jul 2022

DNA must be enormously compressed in sperm cells, study says

If you are moaning once again about your suitcase being far too small as your vacation approaches, you should take human sperm cells as an inspiration.

11 Jul 2022

SARS-CoV-2 spike protein downregulates ACE2 expression

In a new study, researchers observed the downregulation of ACE2 by SARS-CoV-2.

11 Jul 2022

Study sheds light on cell type-specific biomarkers of melanoma

A new UC Davis-led study sheds light on cell type-specific biomarkers, or signs, of melanoma. The research was recently published in the Journal of Investigative Dermatology.

10 Jul 2022

Study illustrates how the use of whole exome sequencing can better predict treatment response

Immunotherapies, such as immune checkpoint inhibitors, have transformed the treatment of advanced stage cancers.

8 Jul 2022

COVID-19 and brain damage explained

In a recent study published in the Brain journal, researchers in the United States analyzed the neurovascular injury in coronavirus disease 2019 (COVID-19).

7 Jul 2022

COVID-19 impairs the insulin/IGF signaling pathway

Scientists evaluate the impact of SARS-CoV-2 on the insulin/IGF signaling pathway.

6 Jul 2022

The role of myostatin in female fertility

A new study discusses some of the key functions of myostatin in female reproductive health and disease.

6 Jul 2022

DZNE and Intravacc receive € 2.5 million EU funding to develop a prototype ALS vaccine

DZNE and Intravacc B.V., a world leading contract development and manufacturing organization (CDMO) of preventive and therapeutic vaccines, have been awarded a funding of € 2.5 million from the European Union (EIC Transition Grant) to further develop a prototype ALS vaccine, including process development, scale-up, and toxicology study.

6 Jul 2022

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

A new study investigated the role of complement component 5a (C5a) and its receptor (C5a receptor type 1, C5aR1) in the pathophysiology of COVID-19.

6 Jul 2022

Study reports how opioids cause gastric inflammation

Opioids are the gold standard for treatment of chronic and acute pain; however, their use may result in significant gastrointestinal side effects, including nausea, vomiting, and constipation.

6 Jul 2022

Researchers reveal the exceptional capacity of Omicron to evade the immune system

The current wave of COVID-19 highlights a particularly high risk of reinfection by the Omicron variant of SARS-CoV-2.

6 Jul 2022

Genetically engineered kidney organoids solve mystery of a rare disease

Researchers have solved a medical mystery in a poorly understood disease by uncovering which cells cause tumors in patients with tuberous sclerosis complex (TSC).

6 Jul 2022

Bone marrow transplants may be an effective treatment for ALS, research suggests

Along with the central nervous system, the immune system may play a fundamental role in Amyotrophic Lateral Sclerosis (ALS), suggesting that bone marrow transplants may be an effective novel treatment for the neurodegenerative disease.

6 Jul 2022

Study results underscore the challenges in treating interstitial pneumonia with autoimmune features

Interstitial pneumonia with autoimmune features (IPAF) is a disease with many possible causes and no standard of care, making it particularly difficult to treat.

5 Jul 2022

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

The viral replication cycle is crucial for a virus to spread inside the body and cause disease. Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) polymerases.

4 Jul 2022

SARS-CoV-2 infection of lung endothelial cells and pulmonary capillary microthrombosis

Researchers evaluated the presence of RNA of SARS-CoV-2 in lung tissue of deceased patients.

4 Jul 2022

Pathology News and Research

Further Reading

Age-related increases in brain inflammation may link Alzheimer's disease risk with sleep disturbance

Prion imaging could lead to better understanding of what causes fatal neurological disorders

Surveillance program for high risk patients aids in early detection of pancreatic cancer

Study reveals a specific metabolic adaptation in some patients with acute myeloid leukemia

DNA must be enormously compressed in sperm cells, study says

SARS-CoV-2 spike protein downregulates ACE2 expression

Study sheds light on cell type-specific biomarkers of melanoma

Study illustrates how the use of whole exome sequencing can better predict treatment response

COVID-19 and brain damage explained

COVID-19 impairs the insulin/IGF signaling pathway

The role of myostatin in female fertility

DZNE and Intravacc receive € 2.5 million EU funding to develop a prototype ALS vaccine

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

Study reports how opioids cause gastric inflammation

Researchers reveal the exceptional capacity of Omicron to evade the immune system

Genetically engineered kidney organoids solve mystery of a rare disease

Bone marrow transplants may be an effective treatment for ALS, research suggests

Study results underscore the challenges in treating interstitial pneumonia with autoimmune features

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

SARS-CoV-2 infection of lung endothelial cells and pulmonary capillary microthrombosis

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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