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Anxiety and negative emotions reduced by brain circuit that consciously slows breathing

Findings on the dACC→PnC circuit show how breathing patterns influence anxiety, paving the way for new therapeutic approaches to emotional regulation.

22 Nov 2024

New microscopy technique enables 3D RNA analysis in intact mouse brains

Researchers at Karolinska Institutet and Karolinska University Hospital have developed a groundbreaking microscopy method that enables detailed three-dimensional (3D) RNA analysis at cellular resolution in whole intact mouse brains.

22 Nov 2024

AI models redefine TIL scoring in breast cancer but face challenges in real-world validation

AI models analyzing tumor-infiltrating lymphocytes show promise in predicting outcomes for triple-negative breast cancer, but external validation reveals critical performance gaps.

21 Nov 2024

BiomedParse transforms biomedical image analysis with groundbreaking precision and scalability

BiomedParse, a revolutionary biomedical model, unifies image segmentation, detection, and recognition across nine modalities, outperforming traditional methods and enabling scalable, precise analysis of complex biomedical images.

21 Nov 2024

New neuroimaging marker may identify persons at risk of dementia in future clinical trials

A new neuroimaging marker of cerebral small vessel disease is related to general cognition and may serve to identify persons at risk of dementia in future clinical trials, a landmark study has found.

21 Nov 2024

UVA researchers discover how blood pressure medications affect kidneys

University of Virginia School of Medicine researchers have discovered how long-term treatment of high blood pressure with commonly prescribed drugs can destroy the kidney's ability to filter and purify blood.

21 Nov 2024

Researchers reveal cellular foundations of functional brain networks in humans

Rutgers researchers at the Brain Health Institute (BHI) and Center for Advanced Human Brain Imaging Research (CAHBIR) have uncovered how different types of brain cells work together to form large-scale functional networks in the human brain – interconnected systems that support everything from sensory processing to complex decision-making – paving the way for new insights into brain health and disease.

21 Nov 2024

Study links prenatal immune activity to Alzheimer's risk in later life

Findings from a Mass General Brigham-led study that has followed participants since before birth may offer clues about the origins of Alzheimer's disease.

21 Nov 2024

Camouflage detection boosts neural networks for brain tumor diagnosis

Research shows that CNNs trained on camouflage detection improve brain tumor classification in MRI scans, highlighting the potential of unconventional training.

21 Nov 2024

New atlas maps 1.6 million human gut cells in unprecedented detail

The most comprehensive cell map of the human gut to date has been created by combining spatial and single-cell data from 1.6 million cells.

21 Nov 2024

Titrzepatide reduces risk of death or worsening heart failure for patients with obesity-related heart failure

Weight-loss and diabetes drug tirzepatide can reduce the risk of death or worsening heart failure for patients with heart failure, preserved heart pump function and obesity, new research from UVA Health reveals.

21 Nov 2024

Nanoparticle coating enhances cancer drug delivery and reduces side effects

A spoonful of sugar might actually help the medicine go down, according to recent research from the University of Mississippi. And it could reduce the harmful side effects of cancer treatment.

21 Nov 2024

Jaw muscle size linked to sarcopenia risk in older adults

As populations age, the prevalence of sarcopenia - a progressive loss of muscle mass and function - has become an increasingly urgent public health concern. Sarcopenia increases the risk of falls and frailty, reduces the quality of life for older adults, and heightens the likelihood of requiring long-term care. Preventing sarcopenia is, therefore, crucial for alleviating this healthcare burden.

20 Nov 2024

Decoding the genetic roots of stroke and heart attack

In a new study published in the European Heart Journal, researchers at Karolinska Institutet show that genetic traits influence the cellular composition of atherosclerotic plaques, which over time will affect the risk of such lesions to cause a stroke or heart attack. The new knowledge can be used to improve the risk assessment and treatment of patients with atherosclerosis in the future.

20 Nov 2024

Squid-inspired technology could replace needles for medications and vaccines

The MiDe systems, inspired by squid propulsion, demonstrate effective needle-free drug delivery in the gastrointestinal tract, rivaling traditional methods.

20 Nov 2024

Barcoding small extracellular vesicles with new CRISPR-based system

Cell-to-cell communication through nanosized particles, working as messengers and carriers, can now be analyzed in a whole new way, thanks to a new method involving CRISPR gene-editing technology.

20 Nov 2024

AI models can be trained to distinguish brain tumors from healthy tissue

A new paper in Biology Methods and Protocols, published by Oxford University Press, shows that scientists can train artificial intelligence models to distinguish brain tumors from healthy tissue.

20 Nov 2024

Creativity camp boosts well-being in teens with depression

Published in Child Psychiatry and Human Development, a research team led by the University of Minnesota Medical School found that Creativity Camp, a two-week arts intervention delivered as a day camp, had a positive impact on mental health and well-being in adolescents with depression.

20 Nov 2024

Experts identify five elements of brain-based visual impairment in children

Experts convened by the National Institutes of Health (NIH) have identified five elements of a brain-based condition that has emerged as a leading cause of vision impairment starting in childhood in the United States and other industrialized nations.

20 Nov 2024

SARS-CoV-2 hijacks cholesterol trafficking to fuel infection and evade immune responses

SARS-CoV-2 disrupts cholesterol metabolism by using its ORF3a protein to sequester cholesterol in lysosomes, reducing BMP levels and optimizing viral survival. This novel mechanism offers insights into long-term metabolic complications of COVID-19.

19 Nov 2024