Efficacy News and Research

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Injection no better than a placebo at preventing influenza in children

U.S. health authorities should have waited for more evidence before recommending routine flu shots for healthy toddlers, according to a new systematic review of studies involving half a million children worldwide.

25 Jan 2006

First-of-its-kind study in heart attack patients seeks to prevent heart failure with stem cells

University of Rochester Medical Center researchers have announced the launch of a study that will examine whether transplanted stem cells can be safely used to treat damaged heart muscle in patients just after their first heart attack.

23 Jan 2006

FDA fast track status for Alfimeprase

Nuvelo Inc. today announced that it has been granted fast track designation by the U.S. Food and Drug Administration (FDA) for its lead product candidate, alfimeprase, for the treatment of acute peripheral arterial occlusion (PAO), or "leg attack."

23 Jan 2006

Novel compound stops brain cell degeneration in Alzheimer's disease

Drug discovery researchers at Northwestern University have developed a novel orally administered compound specifically targeted to suppress brain cell inflammation and neuron loss associated with Alzheimer's disease.

22 Jan 2006

Tamiflu alone won't work in bird flu pandemic

In a review published this week a warning has been issued against the apparent reliance by most countries on the drug Tamiflu to combat a bird flu pandemic.

19 Jan 2006

Uptake of obesity surgery devices to rise as obese population increases

Today, obesity is considered a disease of epidemic proportions. The World Health Organisation (WHO) estimates that obesity has risen by nearly 10-40 per cent in most European countries over the past decade.

18 Jan 2006

Acetazolamide improves central sleep apnea in heart failure

Since sleep apnea is associated with heart failure, patients who take a single dose of acetazolamide - a mild diuretic and respiratory stimulant - before going to bed exhibit less sleep apnea, improved blood oxygen levels and fewer daytime symptoms of sleepiness.

16 Jan 2006

Drugs and electroconvulsive therapy best treatment for severe depression

According to a new study, despite the fact that over the last decade, two treatments which are often castigated in the media, and have raised both public and professional concern, antidepressants such as Prozac and Seroxat, and electroconvulsive therapy (ECT), remain the most effective treatments for moderate to severe depression.

16 Jan 2006

St. Jude projects 90 percent cure rate for acute lymphoblastic leukemia

The cure rate for the once almost universally fatal childhood cancer acute lymphoblastic leukemia (ALL) could reach 90 percent in the near future, thanks to improvements in diagnosis and treatment over the past four decades, according to investigators at St. Jude Children's Research Hospital.

11 Jan 2006

Brain plays a major role in the ability of insulin therapy to lower blood sugar in animals with diabetes

"Our findings suggest that, in individuals with diabetes, the ability of insulin to lower blood sugar involves the brain," said senior author of the study, Michael Schwartz of the University of Washington at Seattle. "This effect is not trivial; the brain makes a substantial contribution to insulin response."

10 Jan 2006

New technique points to safer, more efficient vaccination

Researchers have demonstrated a technique that has the potential to reduce the toxicity of vaccines and to make smaller doses more effective, according to a study published in PLoS Pathogens.

6 Jan 2006

Data establishes safety profile of new GlaxoSmithKline rotavirus vaccine candidate

Data from one of the largest infant vaccine trials ever conducted, published in the New England Journal of Medicine (NEJM), showed GlaxoSmithKline's (GSK) rotavirus vaccine candidate as effective against rotavirus disease (rotavirus gastroenteritis) in the first year of life. Rotavirus is the leading recognized cause of diarrhea-related illness and death among infants and young children.

6 Jan 2006

Prospect of personalized medicine places new demands on the evaluation of new medicines

As we enter the era of personalized medicine, it is time to take a fresh look at how we evaluate new medicines and treatments for cancer, according to Donald Berry, Ph.D., professor and chair of the Department of Biostatistics and Applied Mathematics at The University of Texas M. D. Anderson Cancer Center.

6 Jan 2006

Magnet therapy shows no benefits

Patients should be advised that magnet therapy has no proved benefits, and that any healing effect is likely to be small, say U.S. researchers in this week's British Medical Journal.

6 Jan 2006

Cyclosporine suppresses hepatitis C virus and increases the chance of a sustained virological response after liver transplantation

Liver transplant patients with hepatitis C virus (HCV) achieved significantly better long-term viral response when taking the immunosuppressive agent Cyclosporine along with interferon-ribavirin combination therapy. Cyclosporine also showed efficacy against Hepatitis C virus in vitro.

5 Jan 2006

Abstinence and Abstinence-Only Education: A Review of U.S. Policies and Programs

While few Americans remain abstinent until marriage and most initiate sexual intercourse as adolescents, abstinence from sexual intercourse is an important behavioral strategy for preventing human immunodeficiency virus, other sexually transmitted infections, and unintended pregnancy among adolescents

5 Jan 2006

Surprise discovery helps tackle rabies

In an unexpected discovery, scientists at Jefferson Medical College have found that a tiny change in a rabies virus protein can turn a "safe" virus extremely deadly. The finding has enabled the researchers to refine a vaccine they previously created against rabies in wildlife, making it safer and more effective.

5 Jan 2006

Smokers with a family history of lung cancer encouraged to undergo screening

To detect invasive lung cancer in its early stages, researchers urge current and former smokers who have a strong family history of the disease to take a lung function test and undergo screening with spiral computed tomography. The test is especially important should the previously diagnosed relative be young (around 50).

2 Jan 2006

Technique to reduce the toxicity of vaccines demonstrated

Researchers have demonstrated a technique that has the potential to reduce the toxicity of vaccines and to make smaller doses more effective, according to a study published in PLoS Pathogens.

30 Dec 2005

Stroke risk increases when children with sickle cell disease cease transfusions

Stopping regular blood transfusions in children with sickle cell disease who are at risk for a stroke means their stroke risk likely will return, researchers have found.

30 Dec 2005