Cell Death News and Research

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Study identifies TAK1 gene as a key brake on cancer immunotherapy

Australian researchers have discovered that the TAK1 gene helps cancer cells survive attack from the immune system, revealing a mechanism that may limit the effectiveness of immunotherapy treatments.

19 Dec 2025

New tear gland organoids shed light on the biology of dry eye disease

An estimated 5-15% of people have problems with dry eyes, with symptoms including eye redness, stinging, or burning sensation, and eye fatigue. Dry eye disease (DED) occurs when the eyes' tear glands produce insufficient or poor-quality tears which can be due to allergy or autoimmune disease, hormonal changes, aging, etc.

18 Dec 2025

Study finds a new protein target against KRAS-driven non-small cell lung cancer

Lung cancer is the second-most common cancer and the leading cause of cancer death in the United States.

18 Dec 2025

Combination therapy shows promise to treat a rare, catastrophic pediatric brain cancer

St. Jude Children's Research Hospital scientists identified a promising combination approach to treat a rare, but catastrophic pediatric brain cancer called atypical teratoid rhabdoid tumor (ATRT).

16 Dec 2025

Scientists map how cinnamon’s bioactives interact with cancer signaling

This review synthesizes preclinical evidence showing that cinnamon-derived compounds can modulate inflammation, oxidative stress, apoptosis, and angiogenesis through multiple cancer-related signaling pathways. While biologically plausible, the findings are largely limited to cell and animal models, underscoring the need for pharmacokinetic, safety, and clinical validation.

15 Dec 2025

Researchers explore how the visual brain system recovers following traumatic injury

The brain shows a capacity to recover from traumatic injury, which somewhat contradicts the widely accepted idea that neurons do not regenerate.

15 Dec 2025

New insights into alcohol-related DNA damage and cancer risk

Alcohol consumption leads to the formation of a toxic compound called acetaldehyde, which damages DNA.

15 Dec 2025

Scientists outline how organ rejuvenation strategies could solve the donor shortage

Researchers outline why organs from older donors are often discarded and identify the biological and immunological pathways that make them vulnerable to injury. They also highlight emerging rejuvenation technologies including machine perfusion, senotherapeutics, and regenerative strategies that could safely expand the donor pool.

11 Dec 2025

Psoriasis caused by changes in the fat metabolism of skin cells

A research team led by Erwin F. Wagner from the Medical University of Vienna has discovered a previously unknown molecular mechanism that contributes to the development of psoriasis - and at the same time represents a potential biomarker for a new treatment concept.

11 Dec 2025

Dietary restriction boosts antitumour immunity by rewiring T cell metabolism

Dietary restriction reshapes CD8+ T cell metabolism by increasing ketone body–driven acetyl-CoA production, preventing terminal exhaustion and enhancing tumour control in mice. This metabolic reprogramming also boosts responsiveness to PD-1 blockade, suggesting a potential strategy to improve cancer immunotherapy.

10 Dec 2025

Triaptosis could be a promising strategy in the fight against cancer

Cancer remains one of the most critical global public health challenges, exerting profound social, economic, and clinical burdens while limiting gains in human life expectancy.

10 Dec 2025

Study shines new light on how cancer avoids the mitotic stopwatch pathway

When cell division (mitosis) takes too long, it can be a sign that something is wrong with the cells, for example DNA damage or chromosomal instability.

10 Dec 2025

Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells

This study shows that vacancy-engineered MoS₂ nanoflowers drive mitochondrial biogenesis in human mesenchymal stem cells by activating SIRT1–PGC-1α signaling and reducing oxidative stress. These treated cells transfer more functional mitochondria to injured recipient cells, restoring energy metabolism and redox balance in multiple in vitro models.

9 Dec 2025

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs - a discovery that could open the door to a new class of treatments for leukemia and other hard-to-treat cancers.

9 Dec 2025

Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows quickly, spreads early and lacks the hormone receptors that make other breast cancers treatable with targeted therapies.

5 Dec 2025

Study provides first molecular evidence that ferroptosis can drive neurodegeneration

Researchers at Helmholtz Munich, the Technical University of Munich and the LMU University Hospital Munich uncovered a mechanism that protects nerve cells from premature cell death, known as ferroptosis.

4 Dec 2025

Bacterial enzyme linked to heart complications in pneumonia

Pneumonia is a disease that burdens the healthcare system with more that 1.2 million emergency room visits each year and more than 41,000 adult deaths in the United States.

4 Dec 2025

Early pregnancy placenta models show significant effects from PFAS exposure

Per- and polyfluoroalkyl substances (PFAS) are a group of nearly 10,000 long-lasting chemical compounds that stay in the environment and have been linked to adverse health effects on humans, including pregnant women and their unborn children.

4 Dec 2025

Understanding how adult brains adapt to challenge and change

In a revelatory Genomic Press Interview published today in Brain Medicine, Dr. Paul Lucassen, full professor at the University of Amsterdam and leader of the Brain Plasticity group, shares his scientific journey that helped transform our understanding of how adult brains adapt to challenge and change.

4 Dec 2025