Drug Repurposing News and Research

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Repurposed drug for acute lung injury in COVID-19

Now, a new study addresses the possible use of an FDA-approved monoclonal antibody, called fostamatinib, a spleen tyrosine kinase inhibitor (SYK), to reduce the levels of mucin-1, a molecule associated with acute lung injury and acute respiratory distress syndrome (ARDS). People who have severe COVID-19 disease may develop ARDS.

2 Jul 2020

Researchers perform first X-ray measurements on SARS-CoV-2 main protease

A team of researchers at the Department of Energy's Oak Ridge and Argonne national laboratories has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease -- the enzyme that enables the virus to reproduce.

26 Jun 2020

C-Path announces launch of CURE Drug Repurposing Collaboratory

As millions of patients struggle with diseases that lack adequate treatments, there is a critical need to understand how existing drugs can be used in new ways to improve clinical outcomes.

23 Jun 2020

Steroidal drugs subvert SARS-CoV-2 interaction with ACE2 receptors

A new study by Italian researchers and published online on the preprint server bioRxiv* in June 2020 reports the ability of several existing steroidal drugs to reduce the binding of the SARS-CoV-2 to the ACE2 receptor. This could help define newer strategies using viral entry blockers to reduce viral load.

14 Jun 2020

Does COVID-19 injure the placenta of pregnant women?

News-Medical speaks to Dr. Jeffery Goldstein about whether COVID-19 is damaging the placentas of pregnant women and what women can do to protect themselves.

12 Jun 2020

Research shows potential new therapeutic strategy for slowing down Huntington's disease

Scientists have described a potential new therapeutic strategy for slowing down early-stage Huntington's disease in a new study published today in eLife.

9 Jun 2020

GCS centers support research to fight against global COVID-19 pandemic

In December 2019, the world learned of a new and deadly pathogen. News coming out of Wuhan, China confirmed public health experts' worst fears--a novel coronavirus appeared to have jumped from animals to humans.

11 May 2020

AI-enabled precision medicine may increase survival rate of patients with COVID-19-related sepsis

Data scientists from UK-headquartered AI precision medicine company, PrecisionLife, have used the Company’s proprietary AI enabled precision medicine platform to identify 59 repurposing drug candidates that could be used to develop new therapeutic strategies to increase the survival rate of patients who develop sepsis while suffering from severe COVID-19.

7 May 2020

New study shows the importance of genetic testing in people with solid tumor cancers

A new Cleveland Clinic study demonstrates the importance of genetics evaluation and genetic testing for children, adolescents and young adults with solid tumor cancers

6 May 2020

Low molecular weight heparins inhibit SARS-CoV-2 cell invasion

A recent paper available on the preprint server bioRxiv* reports preliminary data on the ability of low molecular weight heparins to interact with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), elicit structural changes in its key proteins and subsequently halt cell invasion.

3 May 2020

Researchers harness the power of AI to accelerate drug discovery

As the COVID-19 crisis continues to develop, researchers around the world are attempting to find the most effective treatment to combat the poorly understood virus behind this disease.

27 Apr 2020

Biosero and Scripps Research Institute offer automated lab screening for COVID-19 drug therapy candidates

Biosero has designed and implemented an automated lab workflow for Scripps Research Institute so researchers can accelerate the screening of COVID-19 drug therapy candidates.

24 Apr 2020

Scripps Research established international network to find antiviral compounds against COVID-19

With the COVID-19 pandemic continuing to spread around the globe, Scripps Research has quickly established an international network of collaborating scientific laboratories to leverage ReFRAME, the world's leading drug repurposing collection, to find antiviral compounds against the novel coronavirus.

22 Apr 2020

Gold-containing drug auranofin kills 95% of SARS-CoV-2 virus in 48 hours in lab conditions

A drug called auranofin, approved for the treatment of rheumatoid arthritis, effectively inhibits severe acute respiratory syndrome coronavirus (SARS-CoV-2) in laboratory conditions, as described in a new study by Georgia State University researchers.

16 Apr 2020

Scripps Research establishes collaborative global effort to rapidly find drugs against COVID-19

With the COVID-19 pandemic continuing to spread across the globe, Scripps Research has quickly established an international network of collaborating scientific laboratories to leverage ReFRAME, the world's leading drug repurposing collection, to find antiviral compounds against the novel coronavirus.

16 Apr 2020

Pancreatitis drug Nafamostat shows promise for coronavirus

With the increasing number of infections across the globe, scientists have resorted to studying existing drugs in the hope of discovering a cure for the coronavirus disease (COVID-19). A team of researchers has found that an existing drug, Nafamostat or Fusan, a drug used to treat acute pancreatitis, may effectively block the process used by the novel coronavirus to spread and cause illness.

1 Apr 2020

Gero uses AI platform to identify potential anti-COVID-19 drugs

Gero, the leader in AI-driven drug discovery, has used its AI platform to identify the potential anti-COVID-19 drugs. Six of them have been approved, three were withdrawn, and the other nine have been already tested in clinical trials for other indications.

25 Mar 2020

Robots and AI deployed to fight against coronavirus

Robots and artificial intelligence are being deployed across the globe in the fight against the coronavirus pandemic.

12 Mar 2020

Already approved drugs may hold the key to treating new coronavirus

The number of people infected with the new corona virus continues to skyrocket, with more than 80000 cases worldwide as of the end of February.

27 Feb 2020

Artificial Intelligence brings a novel antibiotic compound

Researchers from the Massachusetts Institute of Technology (MIT) have made a scientific breakthrough where their machine-learning algorithm or Artificial Intelligence (AI) program successfully created a novel antibiotic compound. The drug has since then been tested on deadly bacteria in the lab, and in lab mice with a considerable amount of success, explain the researchers. The study results appear in the latest issue of the journal Cell.

20 Feb 2020