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Loss of structural protein ACTL7B blocks spermatogenesis in male mice

Mature spermatozoa are characterized by an head, midpiece and a long tail for locomotion. Now, researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Unit "Life & Health" at the University of Bonn have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice.

27 Oct 2023

Cuproptosis subtypes and immune infiltration provide insights into prognosis of hepatocellular carcinoma

Announcing a new publication for Acta Materia Medica journal. The role of cuproptosis, a newly discovered form of programmed cell death, remains poorly understood in hepatocellular carcinoma (HCC).

27 Oct 2023

Genetics and sedimentology combined to refine cyanobacteria biomarker diagnostics

Cyanobacteria are a key species in Earth's history, as they introduced atmospheric oxygen for the first time. The analysis of their evolution therefore provides important insights into the formation of modern aerobic ecosystems.

27 Oct 2023

New treatment combination shows promise for metastatic colorectal cancer patients with rare genetic mutation

An international Phase 3 clinical trial found that metastatic colorectal cancer patients with a rare genetic tumor mutation called KRAS G12C experienced superior progression-free survival rates compared to standard of care when offered a combination treatment of KRAS inhibitor sotorasib and monoclonal antibody panitumumab.

27 Oct 2023

AI-nanopore platform can detect SARS-CoV-2 variants with high accuracy

A rapid, accurate way of testing for COVID-19 infection would be a big step in overcoming the virus' hold over our society.

27 Oct 2023

Somatic mutations in the skin not responsible for the start or spread of psoriasis

Psoriasis -; a chronic skin condition -; is not caused or spread by spontaneous genetic mutations in the skin, new research suggests.

26 Oct 2023

New AI-nanopore platform could revolutionize COVID-19 testing

A rapid, accurate way of testing for COVID-19 infection would be a big step in overcoming the virus' hold over our society.

26 Oct 2023

Increased homozygosity leads to negative effects on fertility in human population, study finds

When it comes to the architecture of the human genome, it's only a matter of time before harmful genes -; genes that could compromise future generations -; arise in a population.

25 Oct 2023

Marijuana's psychoactive compound may alter brain wiring in adolescents

In a mouse study designed to explore the impact of marijuana's major psychoactive compound, THC, on teenage brains, Johns Hopkins Medicine researchers say they found changes to the structure of microglia, which are specialized brain immune cells, that may worsen a genetic predisposition to schizophrenia.

25 Oct 2023

Omicron's edge: boosters pressure SARS-CoV-2 to adapt and evolve

The effects of vaccine booster doses on the adaptive evolution of the virus.

25 Oct 2023

BA.2.86 Omicron sub-variant shows high receptor affinity but moderate neutralization resistance

Study investigates the receptor affinity and antigenicity of the SARS-CoV-2 Omicron BA.2.86 variant, revealing that it does not show higher resistance to neutralization by human sera than other recent variants. Despite its high number of mutations and receptor affinity, the variant is slightly more sensitive to neutralization than the EG.5.1 variant, warranting continued surveillance.

24 Oct 2023

HIF-2α inhibitor belzutifan significantly reduces progression of clear cell renal cell carcinoma

Belzutifan significantly reduced the risk of progression of clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer, in patients previously treated with immune checkpoint inhibitors and anti-angiogenic therapies compared with everolimus in a phase 3 clinical trial.

24 Oct 2023

Genomic surveillance could help detect and slow the spread of deadly 'superbugs'

Harnessing new advances in genomic surveillance technology could help detect the rise of deadly 'superbugs' and slow their evolution and spread, improving global health outcomes, a new Australian study suggests.

24 Oct 2023

Quick genetic test offers hope for sick, undiagnosed kids. but few insurers offer to pay.

Just 48 hours after her birth in a Seattle-area hospital in 2021, Layla Babayev was undergoing surgery for a bowel obstruction.

23 Oct 2023

Decoding schizophrenia: insights and impacts from genetic discoveries

A recent study in Molecular Psychiatry delves into the genetic architecture of schizophrenia, uncovering insights into common and rare genetic variants, treatment resistance, and the evolutionary paradox of the disorder. This research highlights the complex nature of schizophrenia and the need for a transdiagnostic approach to psychiatric research.

22 Oct 2023

Scientists develop gene therapy approach for rare paralyzing disease

The 50 families stretch from the Netherlands and the United Kingdom to the United States and China. Each family has a child who is paralyzed from a mutation in a single gene named Contactin-Associated Protein 1 (Cntnap1).

20 Oct 2023

Atovaquone "chemical vaccine" for malaria could be more feasible than thought

Johns Hopkins researchers looking to develop a long-acting, injectable malaria preventive using atovaquone have shown in a new study that resistance may not be the challenge scientists thought it was, particularly when using atovaquone as a malaria preventive.

20 Oct 2023

Mutation News and Research

Loss of structural protein ACTL7B blocks spermatogenesis in male mice

Cuproptosis subtypes and immune infiltration provide insights into prognosis of hepatocellular carcinoma

Genetics and sedimentology combined to refine cyanobacteria biomarker diagnostics

New treatment combination shows promise for metastatic colorectal cancer patients with rare genetic mutation

AI-nanopore platform can detect SARS-CoV-2 variants with high accuracy

Somatic mutations in the skin not responsible for the start or spread of psoriasis

New AI-nanopore platform could revolutionize COVID-19 testing

Increased homozygosity leads to negative effects on fertility in human population, study finds

Marijuana's psychoactive compound may alter brain wiring in adolescents

Omicron's edge: boosters pressure SARS-CoV-2 to adapt and evolve

BA.2.86 Omicron sub-variant shows high receptor affinity but moderate neutralization resistance

HIF-2α inhibitor belzutifan significantly reduces progression of clear cell renal cell carcinoma

Genomic surveillance could help detect and slow the spread of deadly 'superbugs'

Quick genetic test offers hope for sick, undiagnosed kids. but few insurers offer to pay.

Decoding schizophrenia: insights and impacts from genetic discoveries

Scientists develop gene therapy approach for rare paralyzing disease

Atovaquone "chemical vaccine" for malaria could be more feasible than thought

Ferroptosis regulation of GLS2 as a potential therapeutic strategy against liver diseases

Plant geneticists explore predictability of natural and CRISPR mutations

Precision oncology therapies account for nearly half of new cancer drug approvals since 1998

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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