Hippocampus News and Research

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The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain.

Breakthrough discovery reveals key role of ovoid cells in object recognition memory

Take a look around your home and you'll find yourself surrounded by familiar comforts-photos of family and friends on the wall, well-worn sneakers by the door, a shelf adorned with travel mementos.

13 Feb 2025

Identifying key brain circuit opens doors for new psychosis treatments

Our study investigated the brain circuits involved in psychosis-a condition characterized by delusions, hallucinations, disorganized thinking and detachment from reality.

13 Feb 2025

Novel biomarker for early prevention of Alzheimer’s disease

New serine biomarkers show promise for early Alzheimer's detection, linking tau assemblies to cognitive decline and offering potential for timely intervention.

11 Feb 2025

Research unveils synergistic effects of tau and beta-amyloid in Alzheimer's

A research team from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has discovered that the two key pathological hallmarks of Alzheimer's-tau protein and beta-amyloid-affect brain circuits in distinct yet synergistic ways, particularly those linked to memory and emotions.

6 Feb 2025

Fruit fly research uncovers brain signals behind alcohol-induced insomnia

Alcohol use disorder, which affects over 10% of Americans, can lead to persistent and serious insomnia. Difficulties falling asleep and staying asleep can last even after months of sobriety, increasing the risk of relapse.

6 Feb 2025

Experimental drug shows promise in restoring memory in Alzheimer's model

A paradigm-shifting study from the Centre for Addiction and Mental Health (CAMH) shows an experimental drug, GL-II-73, has the potential to restore memory and cognitive function in a mouse model of Alzheimer's disease.

4 Feb 2025

Lycopene shows potential as a natural antidepressant

Emerging evidence suggests that lycopene-a natural plant extract-may have antidepressant properties. New research in Food Science & Nutrition reveals the mechanisms behind its antidepressant effects.

4 Feb 2025

Lifelong exercise linked to lower dementia risk

People who exercise throughout their lives have a better chance of avoiding dementia - even if they show signs of diseases like Alzheimer's, finds a new study led by UCL researchers.

31 Jan 2025

Prolonged REM sleep latency linked to Alzheimer’s disease biomarkers

Research indicates longer REM latency is associated with higher Alzheimer's biomarkers, pointing to its potential as an early indicator of neurodegeneration.

29 Jan 2025

Study reveals sex-specific differences in microglial response to CSF1R inhibition

Researchers investigate the sex-dependent microglial response to a colony-stimulating factor 1 receptor (CSF1R) inhibitor.

24 Jan 2025

New genomic insights could transform bipolar disorder treatment

Study published in Nature identifies nearly 300 genomic regions associated with bipolar disorder, and 36 key genes involved in the disease.

23 Jan 2025

Diagnostic guidelines released for limbic-predominant age-related TDP-43 encephalopathy

New guidelines will help doctors identify patients with a common memory-loss syndrome that is often misdiagnosed as Alzheimer's disease in older adults.

22 Jan 2025

New study uncovers brain neurons driving fat and sugar consumption

Researchers identify distinct neuronal populations within the dorsal HPC that respond to certain nutrients and influence obesity.

20 Jan 2025

Mapping neuronal IL-1R1 expression reveals insights into brain function

Interleukin-1 (IL-1) is a key molecule involved in inflammation and plays an important role in both healthy and diseased states.

17 Jan 2025

Brain neurons that respond to sugar and fat offer new insights into obesity control

The study uncovers hippocampal neurons that differentially respond to sugars and fats, suggesting new avenues for combating obesity through targeted therapies.

17 Jan 2025

Researchers develop a computational model of grid cell-mediated episodic encoding

Nearly 50 years ago, neuroscientists discovered cells within the brain's hippocampus that store memories of specific locations. These cells also play an important role in storing memories of events, known as episodic memories. While the mechanism of how place cells encode spatial memory has been well-characterized, it has remained a puzzle how they encode episodic memories.

16 Jan 2025

Unlocking the neural basis of overeating

Can memory influence what and how much we eat? A groundbreaking Monell Chemical Senses Center study, which links food memory to overeating, answered that question with a resounding "Yes." Led by Monell Associate Member Guillaume de Lartigue, PhD, the research team identified, for the first time, the brain's food-specific memory system and its direct role in overeating and diet-induced obesity.

16 Jan 2025

Exercise offers hope in the Alzheimer's battle

Regular aerobic exercise could significantly reduce disease markers associated with Alzheimer's, new research led by scientists at the University of Bristol (UK) and the Federal University of São Paulo (Brazil) has found. The findings provide new hope in the battle against this devastating disorder.

16 Jan 2025

Uncovering the neurobiological mechanisms of delta opioid receptor agonists

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, including slow action and adverse effects with long-term use. This underscores the urgent need for novel, rapidly-acting therapeutic agents with minimal side effects.

15 Jan 2025

Sleep loss triggers intrusive memories by disrupting REM sleep

Sleep deprivation affects the brain's memory control, with REM sleep essential for effective suppression of intrusive memories and cognitive function.

13 Jan 2025