Messenger RNA (mRNA) News and Research

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Research indicates that mRNA vaccine-induced T cells respond robustly to new SARS-CoV-2 variants

To address the gaps in the knowledge, a team of researchers from the University of California and the Gladstone Institute of Virology conducted 39-parameter phenotyping by cytometry by time of flight (CyTOF) on 33 longitudinal specimens from 11 mRNA-vaccinated individuals, of which six had previously been infected and recovered from COVID-19.

18 Oct 2021

Mix-and-match booster shots beneficial in boosting SARS-CoV-2 immunity

Should you get a second dose of the same vaccine if you’ve received the one-dose Johnson & Johnson shot? According to new clinical trial results published on the preprint medRxiv* server, a booster shot of a messenger RNA (mRNA) vaccine may increase your chances of neutralizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Oct 2021

Study reveals the zoonotic potential of the rat Sialodacryoadenitis virus

A new review aimed to describe the current state of knowledge on Sialodacryoadenitis virus, along with its characteristics and potential zoonotic threat.

13 Oct 2021

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

Researchers in Germany have developed a promising approach to suppressing the viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

12 Oct 2021

Role of S-acylation in SARS-CoV-2 infectivity

A new study published in Developmental Cell investigates S-acylation of the SARS-CoV-2 S protein.

10 Oct 2021

Israeli Pfizer COVID vaccine/myocarditis study, 136 cases out of 5 million

A new study, published in the New England Journal of Medicine, aimed to present clinical, epidemiological, and follow-up findings of myocarditis cases diagnosed in temporal proximity to COVID-19 vaccination and explore the possibility of a causal relationship between the two.

7 Oct 2021

Acute myocarditis extremely rare after COVID mRNA vaccination in adults

Now, a new study published in the journal JAMA Internal Medicine evaluated the incidence of acute myocarditis and clinical outcomes among adults who received the mRNA vaccine in an integrated health care system in the United States.

5 Oct 2021

Moderna's COVID-19 vaccine proves effective against multiple SARS-CoV-2 variants, including delta

Researchers in the United States have demonstrated the real-world effectiveness of Moderna’s mRNA-1273 vaccine at protecting against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and preventing hospitalization due to coronavirus disease 2019 (COVID-19).

4 Oct 2021

Pediatric transplant recipients mount a more robust immune response after two COVID-19 vaccine doses

In a study published today in the American Journal of Transplantation, Johns Hopkins Medicine researchers say that children between the ages of 12 and 18 who have received solid organ transplants appear to mount a more robust immune response than their adult counterparts after a standard two-dose vaccination regimen against SARS-CoV-2, the virus that causes COVID-19.

30 Sep 2021

Quantification of antibody titers against SARS-CoV-2 variants elicited by BNT162b2 vaccine

A new study discusses the development of dedicated reagents against the SARS-CoV-2 spike protein through the use of an automated CLEIA system.

28 Sep 2021

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

A new review article investigates the clinical and viral characteristics, pathogenesis, as well as human genetic basis associated with COVID-19.

27 Sep 2021

mRNA COVID vaccines prove effective in the elderly

Coronavirus disease 2019 (COVID-19) proved extremely difficult to control once it entered a country – while there were a few success stories such as New Zealand, most countries ended up resorting to lengthy and economically painful lockdowns, among other restriction measures.

27 Sep 2021

Design of mRNA vaccines to combat COVID-19

A recent review study discusses fundamental concepts in the successful delivery of nucleic acids in therapeutics.

23 Sep 2021

New discovery offers clues to overcoming resistance to cancer therapies

Cancer cells proliferate despite a myriad of stresses - from oxygen deprivation to chemotherapy - that would kill any ordinary cell.

23 Sep 2021

Study shows efficacy of mRNA vaccines against SARS-CoV-2 in individuals with obesity

A new study evaluated the antibody response against SARS-CoV-2 between individuals who were affected by abdominal obesity (AO) and those who were not,

19 Sep 2021

New NIH-funded research to solve the male infertility and spermatogenesis puzzle

Male infertility is on the rise, with significant declines in sperm quantity and quality occurring across the human population worldwide in the past two decades.

16 Sep 2021

Pfizer-BioNTech’s COVID-19 vaccine proves effective against recent SARS-CoV-2 variants

Researchers in the United States and Germany have conducted a study showing that the Pfizer-BioNTech vaccine designed to protect against coronavirus disease 2019 (COVID-19) is effective against recently emerged variants of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2).

16 Sep 2021

Heart inflammation more common among men following mRNA-based COVID-19 vaccination

Researchers in the UK have assessed data from around the world to better understand the frequency and risk factors for myocarditis and pericarditis following immunization with messenger RNA (mRNA)-based vaccines designed to protect against coronavirus disease 2019 (COVID-19).

16 Sep 2021

New SARS-CoV-2 mechanism of host gene suppression

A new study finds that the viral non-coding RNA dubbed vmiR-5p, derived from the viral gene ORF7a, appears to reduce host transcription.

13 Sep 2021

Researchers find a way to turn SARS-CoV-2’s virulence mechanism against itself

A recent study, currently available on the bioRxiv* preprint server, reveals that a specific region of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be targeted by antisense oligonucleotides to potently inhibit viral replication, and consequently the development of coronavirus disease (COVID-19).

12 Sep 2021

Messenger RNA (mRNA) News and Research

Research indicates that mRNA vaccine-induced T cells respond robustly to new SARS-CoV-2 variants

Mix-and-match booster shots beneficial in boosting SARS-CoV-2 immunity

Study reveals the zoonotic potential of the rat Sialodacryoadenitis virus

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

Role of S-acylation in SARS-CoV-2 infectivity

Israeli Pfizer COVID vaccine/myocarditis study, 136 cases out of 5 million

Acute myocarditis extremely rare after COVID mRNA vaccination in adults

Moderna's COVID-19 vaccine proves effective against multiple SARS-CoV-2 variants, including delta

Pediatric transplant recipients mount a more robust immune response after two COVID-19 vaccine doses

Quantification of antibody titers against SARS-CoV-2 variants elicited by BNT162b2 vaccine

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

mRNA COVID vaccines prove effective in the elderly

Design of mRNA vaccines to combat COVID-19

New discovery offers clues to overcoming resistance to cancer therapies

Study shows efficacy of mRNA vaccines against SARS-CoV-2 in individuals with obesity

New NIH-funded research to solve the male infertility and spermatogenesis puzzle

Pfizer-BioNTech’s COVID-19 vaccine proves effective against recent SARS-CoV-2 variants

Heart inflammation more common among men following mRNA-based COVID-19 vaccination

New SARS-CoV-2 mechanism of host gene suppression

Researchers find a way to turn SARS-CoV-2’s virulence mechanism against itself

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