Proliferation News and Research

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Nervous system can "put the brakes" on immune response and prevent excessive inflammation

Cells in the nervous system can "put the brakes" on the immune response to infections in the gut and lungs to prevent excessive inflammation, according to research by Weill Cornell Medicine scientists. This insight may one day lead to new ways to treat diseases caused by unchecked inflammation, such as asthma and inflammatory bowel disease.

2 Mar 2018

Researchers develop method to make adult cardiomyocytes divide and repair damaged hearts

Some organisms have a remarkable capacity for regenerating tissue. If a fish or salamander suffers heart damage, for instance, their cells are able to divide and successfully repair the injured organ. Imagine if you could do the same.

2 Mar 2018

UNIGE researchers discover why premature cell division promotes tumor formation

The accumulation of mutations in the human genome is at the origin of cancers, as well as the development of resistance to treatments. The Cyclin E and Myc genes are active in the control of cell division.

28 Feb 2018

Pancreatic progenitor cells could be used to treat diabetes, suggests study

Researchers have confirmed the existence of progenitor cells in the pancreas that can be stimulated to turn into glucose-responsive beta cells.

28 Feb 2018

Researchers demonstrate novel process to produce cell-sized lipid vesicles

A team of researchers at the University of California in Irvine, California has demonstrated a novel process to produce cell-sized lipid vesicles (CLVs) from microfluidically generated double emulsion templates by investigating the interfacial parameters that control double emulsion stability for storage, and their subsequent dewetting to form multisomes or GUVs (subsets of CLVs).

24 Feb 2018

Carbon monoxide enhances efficacy of antibiotic against stomach infection

Carbon monoxide can improve the effectiveness of antibiotics, making bacteria more sensitive to antibiotic medication, according to a study led by Georgia State University.

22 Feb 2018

Researchers discover new interaction mechanism of unstructured proteins

Proteins are among the most important biomolecules and are the key mediators of molecular communication between and within cells. For two proteins to be able to bind, specific regions of their three-dimensional structure have to exactly match one another - like a key that fits into a lock.

22 Feb 2018

Researchers target abnormal epigenetic mechanisms involved in childhood cancers

Several childhood cancer cell types show features of immature neural cells, and there is evidence suggesting that these tumors may arise from neural crest stem cells that underwent abnormal changes during embryonic development.

20 Feb 2018

Key protein involved in epigenetic regulation of gene expression guides skin cell renewal

Approximately once a month, our skin completely renews itself. If this highly coordinated process goes awry, it can lead to a variety of skin diseases, ranging from skin cancer to psoriasis.

19 Feb 2018

Scientists use novel epigenetic-centered techniques to inhibit cancer metastases

In one of the first successes of its kind, researchers from Case Western Reserve University School of Medicine and six other institutions have inhibited the spreading of cancer cells from one part of the body to another.

12 Feb 2018

Researchers use molecular simulations to understand lung cancer drug resistance

Scientists from the Universities of Bristol and Parma, Italy, have used molecular simulations to understand resistance to osimertinib - an anticancer drug used to treat types of lung cancer.

12 Feb 2018

Cardiomyocytes fuse transiently during heart development and regeneration

Cardiomyocytes fuse during cardiac development and regeneration. A scientist of the German Centre for Cardiovascular Research (DZHK) discovered these previously unknown processes with the aid of genetically modified zebrafish in which fused cells fluoresce.

9 Feb 2018

CSU researchers find cause of Legionnaires' disease outbreak in Flint

An outbreak of Legionnaires' disease in 2014-15 in Flint, Michigan, was likely caused by a change in the city's drinking water supply, according to a study led by Colorado State University researchers.

6 Feb 2018

Ribosomes found to be cause of somatic cell pluripotency

In 2012, a Japanese research group discovered that human skin cells acquire pluripotency when introduced to lactic acid bacteria. Now, the same group of researchers have found that the cause of somatic cell conversion into pluripotent stem cells is the ribosome, a protein synthesizing cellular organelle.

5 Feb 2018

Researchers use innovative method to screen kinases for cancer drug's effectiveness

In recent years, a powerful suite of drugs known as kinase inhibitors have been developed to treat cancer and other diseases. Primary targets of such drugs include a family of receptor tyrosine kinases (RTKs) which protrude from cell surfaces like antennae and can activate cancer-related pathways in virtually all types of cancer when signaling molecules bind with them.

5 Feb 2018

Higher susceptibility of some babies to Zika virus has a genetic origin, study shows

Microcephaly, brain calcification, skeletal alterations, auditory and visual deficits - these are examples of the damage that can be caused by Zika virus in babies born to mothers infected during pregnancy.

2 Feb 2018

Researchers identify cause of severe genetic disease

Mutations in the p63 protein lead to a number of disorders, but none is as severe as the AEC syndrome. Scientists at Goethe University Frankfurt in collaboration with a research group from the University of Naples Federico II have now discovered that this syndrome resembles diseases such as Alzheimer's, Parkinson's or ALS more closely than it does other p63-based syndromes.

2 Feb 2018

Scientists discover role of two specific HOX genes in colon cancer development

In breakthrough colon cancer research, scientists at Christiana Care Health System's Center for Translational Cancer Research of the Helen F. Graham Cancer Center & Research Institute have discovered that over-expression of HOXA4 and HOXA9 genes in colon cancer stem cells promotes cell replication and contributes to the overpopulation of stem cells that drives colon cancer development.

31 Jan 2018

Study provides novel insights into evolutionary pathways of pancreatic cancer

Pancreatic cancer is a form of cancer associated with the highest mortality rates in the world. Genetic changes that could explain his aggressiveness and early metastasis had not been found yet.

30 Jan 2018

Vitamin deficiency prevents proliferation of cancer stem cells

DPI effectively switches off the cancer stem cells, preventing their proliferation. "It's extraordinary; the cells just sit there as if in a state of suspended animation" explains Professor Michael Lisanti, Chair of Translational Medicine and lead investigator.

30 Jan 2018