Therapeutics News and Research

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Intranasal delivery of CRISPR/Cas9 therapeutics may help treat chronic anxiety

A study in mice reports a CRISPR/Cas9 gene-editing delivery system, capable of bypassing the blood-brain-barrier and modulating neuronal receptor pathways, to treat chronic anxiety.

20 Jun 2023

The contribution of transcription factor ROB1 to the pathophysiology of C. albicans-induced candidal infections

Researchers evaluated the function of the zinc finger transcription factor ROB1 and its two phenotypically distinct alleles in the pathogenesis of Candida albicans infections.

20 Jun 2023

Injectable osteoporosis drug can be safely administered orally using a novel 'robotic pill'

A proven and effective medication for osteoporosis, which is currently only available as an injection, can be administered orally using a novel "robotic pill," according to a study presented Saturday at ENDO 2023, the Endocrine Society's annual meeting in Chicago, Ill.

18 Jun 2023

Adagrasib shows promise for the treatment of patients with KRAS G12C-mutated non-small cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center found the KRAS G12C inhibitor adagrasib showed promising activity suppressing cancer growth not only within the lungs but also in brain metastases for patients with KRAS G12C-mutated non-small cell lung cancer.

16 Jun 2023

Study concludes a single intramuscular injection of adintrevimab provides prophylactic efficacy against COVID-19 without safety concerns

Researchers evaluated the prophylactic immune protection conferred by a single intramuscular injection of adintrevimab (ADG20) against symptomatic COVID-19.

16 Jun 2023

From COVID-19 to future threats: building a global genomic surveillance network

Researchers present a modular framework for global sustainable networks of viral genomic surveillance.

16 Jun 2023

Bempedoic acid may offer an alternative to the popular cholesterol-lowering drugs

A medication called bempedoic acid reduced the risk of cardiac events as well as statins and may offer an alternative to the popular cholesterol-reducing medications, according to industry-supported research being presented Thursday at ENDO 2023, the Endocrine Society's annual meeting, in Chicago, Ill.

15 Jun 2023

Scientist identifies the specific mechanistic cause of life-threatening fungal infections

Major fungal infections have become more common across the globe, and one unexpected phenomenon among the rise of fungi is life-threatening infections as a result of a complication of certain immunotherapies and small molecule kinase inhibitors.

15 Jun 2023

KU investigator develops treatment for stroke, heart disease, other metabolic diseases

An investigator with the University of Kansas School of Pharmacy has filed an invention disclosure, part of a provisional patent application with the United States Patent and Trademark Office, for a treatment that could apply to heart disease, stroke and a host of other human diseases related to metabolism.

15 Jun 2023

Cerillo showcases wireless, scalable, off-the-shelf co-culture solution

Cerillo, a biotechnology company at the forefront of developing advanced research platforms for the study of the microbiome, will host demonstrations of the company’s new co-culture duet system at ASM Microbe 2023 from June 16-18th in Houston, Texas at booth #704.

From Cerillo 15 Jun 2023

Scientists identify major mechanism behind the transition between chronic and acute bacterial infections

People with weakened immune systems are at constant risk of infection. Pseudomonas aeruginosa, a common environmental bacterium, can colonize different body parts, such as the lungs, leading to persistent, chronic infections that can last a lifetime – a common occurrence in people with cystic fibrosis.

14 Jun 2023

Study finds altered gut bacteria in people with early signs of Alzheimer's disease

People in the earliest stage of Alzheimer's disease - after brain changes have begun but before cognitive symptoms become apparent - harbor an assortment of bacteria in their intestines that differs from the gut bacteria of healthy people, according to a study by researchers at Washington University School of Medicine in St. Louis.

14 Jun 2023

Using ultrasound for an effective sonodynamic treatment of orthotopic pancreatic cancer

Ultrasound is a promising technique for treating cancer. Unlike laser light, used in photodynamic cancer therapy, ultrasound waves can reach deep into tissue - up to 12 cm - to treat deep tumors without damaging healthy cells.

14 Jun 2023

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals - from fuels to fabrics and drugs - beyond the normal repertoire of microbes.

13 Jun 2023

New process for creating a “meta-cell overcomes the challenges of studying single-cell secrets

University of California, Irvine neuroscientists probing the gene changes behind Alzheimer's disease have developed a process of making a "meta-cell" that overcomes the challenges of studying a single cell.

13 Jun 2023

Study illuminates how T cells fight and remember infections

The immune system protects the body from invaders, such as bacteria, viruses, or tumors, with its intricate network of proteins, cells, and organs.

13 Jun 2023

Study reveals biologically validated imaging-based evidence of medically induced myelin repair

A decade after UC San Francisco scientists identified an over-the-counter antihistamine as a treatment for multiple sclerosis, researchers have developed an approach to measure the drug's effectiveness in repairing the brain, making it possible to also assess future therapies for the devastating disorder.

13 Jun 2023

Metformin shows promising antiviral activity against SARS-CoV-2

Metformin, a widely available oral medication, reduces SARS-CoV-2 viral load by 3.6-fold in outpatient trial, offering a potential treatment option. Ivermectin and fluvoxamine show no significant virologic effect.

12 Jun 2023

Metformin reduces risk of long COVID by over 40%

Researchers discuss whether metformin, ivermectin, or fluvoxamine could reduce the risk of long COVID if administered shortly after infection.

12 Jun 2023

Researchers identify a potential breakthrough in glioblastoma treatment

In a recently published manuscript, Howard Colman, MD, PhD, Jon M. Huntsman Presidential Professor of Neuro-Oncology and co-leader of the Neurologic Cancers Disease Center and the Experimental Therapeutics CCSG program at Huntsman Cancer Institute, identified a potential breakthrough in glioblastoma treatment.

12 Jun 2023

Therapeutics News and Research

Intranasal delivery of CRISPR/Cas9 therapeutics may help treat chronic anxiety

The contribution of transcription factor ROB1 to the pathophysiology of C. albicans-induced candidal infections

Injectable osteoporosis drug can be safely administered orally using a novel 'robotic pill'

Adagrasib shows promise for the treatment of patients with KRAS G12C-mutated non-small cell lung cancer

Study concludes a single intramuscular injection of adintrevimab provides prophylactic efficacy against COVID-19 without safety concerns

From COVID-19 to future threats: building a global genomic surveillance network

Bempedoic acid may offer an alternative to the popular cholesterol-lowering drugs

Scientist identifies the specific mechanistic cause of life-threatening fungal infections

KU investigator develops treatment for stroke, heart disease, other metabolic diseases

Cerillo showcases wireless, scalable, off-the-shelf co-culture solution

Scientists identify major mechanism behind the transition between chronic and acute bacterial infections

Study finds altered gut bacteria in people with early signs of Alzheimer's disease

Using ultrasound for an effective sonodynamic treatment of orthotopic pancreatic cancer

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

New process for creating a “meta-cell overcomes the challenges of studying single-cell secrets

Study illuminates how T cells fight and remember infections

Study reveals biologically validated imaging-based evidence of medically induced myelin repair

Metformin shows promising antiviral activity against SARS-CoV-2

Metformin reduces risk of long COVID by over 40%

Researchers identify a potential breakthrough in glioblastoma treatment

Understanding the DNA Damage Response in Innate Immunity eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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