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AXT add Vieworks bio-imaging solutions to their preclinical imaging portfolio

AXT is excited to add the Vieworks range of bio-imaging systems to their preclinical imaging product portfolio. Their in-vivo imaging systems provide outstanding performance in bioluminescent and fluorescent imaging and represents excellent value.

From AXT Pty Ltd 26 Sep 2020

Study identifies hiding place where tumor cells shelter from chemotherapy in childhood leukemia

The stroma of the choroid plexus is one of the locations within the central nervous system (CNS) that serves as a shelter for tumor cells, allowing them to elude chemotherapy and potentially cause subsequent relapses in childhood acute lymphoblastic leukaemia, according to research led by the Complutense University of Madrid.

25 Sep 2020

New material identifies cancer cells and mounts a surprising attack

Many people across the globe are working hard to get the better of cancer; however cancer is always working too. Cancer cells can become resistant to the methods that have been adopted to kill them, so identifying drugs that act in different ways is part of the push to outsmart this ubiquitous disease

25 Sep 2020

Human-to-cat transmission of SARS-CoV-2 confirmed

Cat-to-cat transmission of SARS-CoV-2 has been experimentally proven, but little is known about the significance of this novel virus as a feline pathogen or its reverse zoonotic potential. The establishment of new animal reservoirs of SARS-CoV-2 could pose serious problems for human health in the future.

24 Sep 2020

AI used to define the cytokine storm implicated in fatal COVID-19

A new study published on the preprint server bioRxiv* in September 2020 reports the use of artificial intelligence (AI) to identify an invariant or universal host immune response found in all viral pandemics so far. The association of this response with severe COVID-19 phenotypes indicates a new understanding of the human immune response in viral pandemics.

24 Sep 2020

Discovering a molecule that could interfere with SARS-CoV-2 replication

In this interview, News-Medical speaks to Stepan Nersisyan about his discovery of a molecule that could replicate SARS-CoV-2.

22 Sep 2020

Inhibition of SARS-CoV-2 with antisense oligonucleotides

A part of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA is highly conserved. Researchers have used this as a target for designing antisense oligonucleotide gapmers to cleave the RNA and disrupt virus replication. Their research is published as a preprint on the online server bioRxiv in September 2020.

22 Sep 2020

Soluble ACE2 microbody blocks SARS-CoV-2 entry into lung cells

A new study by researchers at NYU Langone Medical Center and Weill Cornell Medical College and published on the preprint server bioRxiv* in September 2020 reports the potential of an angiotensin-converting enzyme 2 (ACE2)-antibody Fc complex in a new format that seems to offer more significant inhibition of SARS-CoV-2.

21 Sep 2020

Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Using mouse models, scientists have investigated the active plasma metabolite of remdesivir, GS-441 524, and hydroxychloroquine as possible drug candidates in COVID-19. The research shows GS-441 524 could be an effective therapeutic drug against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while at the same time discounting hydroxychloroquine as a reliable anti-viral.

20 Sep 2020

Scientists identify new drug to prevent SARS-CoV-2 infection consequences

Scientists from the Department of Cell Biology of the University of Malaga and the Andalusian Centre for Nanomedicine and Biotechnology have made progress in finding new rapid implementation therapies to combat the COVID-19 pandemic, identifying a new drug that could prevent or mitigate the consequences derived from SARS-CoV-2 infection.

19 Sep 2020

Research provides deeper understanding of how neurons in the nose react to odors

Take a sniff of a freshly poured glass of wine, and the prevailing scientific thinking would suggest that the harmony of fragrances you perceive starts with sensory receptors in your nose simply adding up the individual odors they encounter.

19 Sep 2020

Study invalidates Ebselen and other broad-spectrum SARS-CoV-2 Mpro inhibitors

Other novel compounds with Mpro inhibitory activity have also been claimed to have antiviral activity. These include ebselen, disulfiram, tideglusib, carmofur, shikonin, and PX-12. A new research paper discusses the role of these molecules as potential Mpro inhibitors in the prevention of SARS-CoV-2 infection.

18 Sep 2020

Study: Pleotropic drugs can have both favorable and unfavorable effects on cell growth, survival

The cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21.

17 Sep 2020

Optimal antibody combinations and Fc binding inhibit SARS-CoV-2 in vivo

A recent study by researchers at the University of North Carolina at Chapel Hill and The Rockefeller University and published on the preprint server bioRxiv in September 2020 shows that a combination of neutralizing antibodies with intact Fc effector function can effectively reduce the viral load and prevent infection.

17 Sep 2020

Researchers develop 3D functional heart organoids from mouse embryonic stem cells

Heart development as it happens in vivo, or in a living organism, is a complex process that has traditionally been difficult to mimic in vitro, or in the laboratory.

16 Sep 2020

Pfizer's anti-viral 3CL protease inhibitor shows antiviral potential against SARS-CoV-2

Now, a new study by researchers from Pfizer, University of Arizona, Purdue University, The Scripps Research Institute, and UC San Diego School of Medicine and published on the preprint server bioRxiv in September 2020 reports that an enzyme inhibitor may act in synergism with the approved antiviral remdesivir to suppress viral replication in COVID-19.

16 Sep 2020

Researchers develop protein-based biosensor for multiplex imaging of neurotransmitter

In 2018, Lin Tian and her team at UC Davis Health developed dLight1, a single fluorescent protein-based biosensor. This family of highly specific sensors detects dopamine, a hormone released by neurons to send signals to other nerve cells.

16 Sep 2020

SARS-CoV-2 N protein forms biomolecular condensates with viral RNA

Now, a study by researchers from the University of California has shown that the N protein forms biomolecular condensates with the viral RNA in both in vitro and in vivo studies. The research titled, ‘SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA’, was published on the preprint server bioRxiv on September 14th, 2020.

15 Sep 2020

Can amodiaquine short circuit this pandemic?

A recent study by the US researchers highlights the value of the human organ chip technology as a more robust and physiologically relevant platform for rapid drug repurposing, and suggest that amodiaquine may be used to prevent the infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

15 Sep 2020

New bone-on-a-chip device could revolutionize pharmaceutical pre-clinical testing

A new technology that could be used to test new treatments for human organs and bone tissue - all whilst reducing the need for animal research - has been developed by engineers at the University of Sheffield.

14 Sep 2020

in vivo News and Research

AXT add Vieworks bio-imaging solutions to their preclinical imaging portfolio

Study identifies hiding place where tumor cells shelter from chemotherapy in childhood leukemia

New material identifies cancer cells and mounts a surprising attack

Human-to-cat transmission of SARS-CoV-2 confirmed

AI used to define the cytokine storm implicated in fatal COVID-19

Discovering a molecule that could interfere with SARS-CoV-2 replication

Inhibition of SARS-CoV-2 with antisense oligonucleotides

Soluble ACE2 microbody blocks SARS-CoV-2 entry into lung cells

Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Scientists identify new drug to prevent SARS-CoV-2 infection consequences

Research provides deeper understanding of how neurons in the nose react to odors

Study invalidates Ebselen and other broad-spectrum SARS-CoV-2 Mpro inhibitors

Study: Pleotropic drugs can have both favorable and unfavorable effects on cell growth, survival

Optimal antibody combinations and Fc binding inhibit SARS-CoV-2 in vivo

Researchers develop 3D functional heart organoids from mouse embryonic stem cells

Pfizer's anti-viral 3CL protease inhibitor shows antiviral potential against SARS-CoV-2

Researchers develop protein-based biosensor for multiplex imaging of neurotransmitter

SARS-CoV-2 N protein forms biomolecular condensates with viral RNA

Can amodiaquine short circuit this pandemic?

New bone-on-a-chip device could revolutionize pharmaceutical pre-clinical testing

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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