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Study invalidates Ebselen and other broad-spectrum SARS-CoV-2 Mpro inhibitors

Other novel compounds with Mpro inhibitory activity have also been claimed to have antiviral activity. These include ebselen, disulfiram, tideglusib, carmofur, shikonin, and PX-12. A new research paper discusses the role of these molecules as potential Mpro inhibitors in the prevention of SARS-CoV-2 infection.

18 Sep 2020

Study: Pleotropic drugs can have both favorable and unfavorable effects on cell growth, survival

The cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21.

17 Sep 2020

Optimal antibody combinations and Fc binding inhibit SARS-CoV-2 in vivo

A recent study by researchers at the University of North Carolina at Chapel Hill and The Rockefeller University and published on the preprint server bioRxiv in September 2020 shows that a combination of neutralizing antibodies with intact Fc effector function can effectively reduce the viral load and prevent infection.

17 Sep 2020

Researchers develop 3D functional heart organoids from mouse embryonic stem cells

Heart development as it happens in vivo, or in a living organism, is a complex process that has traditionally been difficult to mimic in vitro, or in the laboratory.

16 Sep 2020

Pfizer's anti-viral 3CL protease inhibitor shows antiviral potential against SARS-CoV-2

Now, a new study by researchers from Pfizer, University of Arizona, Purdue University, The Scripps Research Institute, and UC San Diego School of Medicine and published on the preprint server bioRxiv in September 2020 reports that an enzyme inhibitor may act in synergism with the approved antiviral remdesivir to suppress viral replication in COVID-19.

16 Sep 2020

Researchers develop protein-based biosensor for multiplex imaging of neurotransmitter

In 2018, Lin Tian and her team at UC Davis Health developed dLight1, a single fluorescent protein-based biosensor. This family of highly specific sensors detects dopamine, a hormone released by neurons to send signals to other nerve cells.

16 Sep 2020

SARS-CoV-2 N protein forms biomolecular condensates with viral RNA

Now, a study by researchers from the University of California has shown that the N protein forms biomolecular condensates with the viral RNA in both in vitro and in vivo studies. The research titled, ‘SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA’, was published on the preprint server bioRxiv on September 14th, 2020.

15 Sep 2020

Can amodiaquine short circuit this pandemic?

A recent study by the US researchers highlights the value of the human organ chip technology as a more robust and physiologically relevant platform for rapid drug repurposing, and suggest that amodiaquine may be used to prevent the infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

15 Sep 2020

New bone-on-a-chip device could revolutionize pharmaceutical pre-clinical testing

A new technology that could be used to test new treatments for human organs and bone tissue - all whilst reducing the need for animal research - has been developed by engineers at the University of Sheffield.

14 Sep 2020

Study demonstrates new method to synthesize gold nanoparticles in cancer cells

Dipanjan Pan, professor of chemical, biochemical, and environmental engineering at UMBC, and collaborators published a seminal study in Nature Communications that demonstrates for the first time a method of biosynthesizing plasmonic gold nanoparticles within cancer cells, without the need for conventional bench-top lab methods.

12 Sep 2020

New antitumor vaccines control melanoma growth in preclinical models

Combining their expertise in protein engineering and synthetic DNA technology, scientists at The Wistar Institute successfully delivered nanoparticle antitumor vaccines that stimulated robust CD8 T cell immunity and controlled melanoma growth in preclinical models.

11 Sep 2020

Effective, simple, safe self-amplifying RNA vaccines

A recent review paper in the journal Current Opinion in Virology in September 2020 shows how a new generation of RNA vaccines called self-amplifying RNA vaccines are more potent than conventional mRNA vaccines and could hold the key to the global production of cost-effective potent COVID-19 vaccines.

11 Sep 2020

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Researchers designed DLnano-vaccines displaying 60 copies of protein parts derived from the melanoma-specific antigens Trp2 and Gp100 and tested these in mouse models of melanoma, observing prolonged survival that depended on CD8 T cell activation both in therapeutic and prophylactic settings.

10 Sep 2020

Scientists explain how SARS-CoV-2 attacks the brain

Now, a team of scientists at Yale University revealed the changes that happen in the brain caused by SARS-CoV-2, the virus that has caused over 27.86 million people and claimed over 903,000 lives.

10 Sep 2020

Pfizer, BioNTech COVID-19 vaccine candidate shows promise in preclinical study

Researchers in the United States and Germany have conducted a study demonstrating the preclinical efficacy of a new candidate vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease 2019 (COVID-19).

9 Sep 2020

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

The cover for issue 36 of Oncotarget features, "Knockdown of APOBEC3B is associated with a lower tumor growth in an adrenocortical carcinoma xenograft mouse model," by Gara, et al. which reported that the role of APOBEC3B in adrenocortical carcinoma and the mechanisms through which its expression is regulated in cancer are not fully understood.

9 Sep 2020

Scientists explain why men are at higher risk from COVID-19

Published in the journal PLOS Biology, the study aimed to provide a better understanding of the mechanisms that drive the varying responses of the infected individuals among different patient demographics, including sex and age.

9 Sep 2020

New medical instruments with smart sensors can improve surgery, therapy for cardiac diseases

Researchers developed a new class of medical instruments equipped with an advanced soft electronics system that could dramatically improve the diagnoses and treatments of a number of cardiac diseases and conditions.

7 Sep 2020

Novel RNA vaccine from Arcturus Therapeutics protects mice against SARS-CoV-2

A new study published on the preprint server bioRxiv in September 2020 reports a novel RNA vaccine platform that shows robust protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in mice and performs much better than a conventional mRNA vaccine. This could allow single-dose immunization, allowing progress towards global vaccination.

6 Sep 2020

Seasonal influenza and COVID-19 risk

In a new study published on the preprint server medRxiv, researchers from Laval University and McGill University in Canada reviewed evidence from 18 relevant studies on a possible interaction between influenza vaccines on non-influenza respiratory disease (NIRD).

6 Sep 2020

in vivo News and Research

Study invalidates Ebselen and other broad-spectrum SARS-CoV-2 Mpro inhibitors

Study: Pleotropic drugs can have both favorable and unfavorable effects on cell growth, survival

Optimal antibody combinations and Fc binding inhibit SARS-CoV-2 in vivo

Researchers develop 3D functional heart organoids from mouse embryonic stem cells

Pfizer's anti-viral 3CL protease inhibitor shows antiviral potential against SARS-CoV-2

Researchers develop protein-based biosensor for multiplex imaging of neurotransmitter

SARS-CoV-2 N protein forms biomolecular condensates with viral RNA

Can amodiaquine short circuit this pandemic?

New bone-on-a-chip device could revolutionize pharmaceutical pre-clinical testing

Study demonstrates new method to synthesize gold nanoparticles in cancer cells

New antitumor vaccines control melanoma growth in preclinical models

Effective, simple, safe self-amplifying RNA vaccines

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Scientists explain how SARS-CoV-2 attacks the brain

Pfizer, BioNTech COVID-19 vaccine candidate shows promise in preclinical study

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

Scientists explain why men are at higher risk from COVID-19

New medical instruments with smart sensors can improve surgery, therapy for cardiac diseases

Novel RNA vaccine from Arcturus Therapeutics protects mice against SARS-CoV-2

Seasonal influenza and COVID-19 risk

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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