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Omics analysis identifies new biomarkers for predicting mortality in patients with pneumonia

Community-acquired pneumonia (CAP) is a major infectious disease worldwide and contributes to high mortality and massive economic burden. Hospital mortality among the severe CAP (SCAP) remains high, ranging from 25% to more than 50%.

22 Sep 2023

Can COVID-19 vaccines turn the tide on long-haul symptoms?

The study finds that COVID-19 vaccination can significantly reduce symptoms and improve well-being in patients suffering from post-COVID-19 conditions (PCC). Vaccination also lowered systemic markers of inflammation but did not entirely eliminate persistent SARS-CoV-2 antigens, which may continue to contribute to inflammation.

22 Sep 2023

CD1 lipidomes exhibit size-based antigen display mechanisms

Study uncovers the complexities of how CD1 molecules present a vast array of lipids to T-cells, revealing a unique, size-based antigen-display system. The findings could provide crucial insights into the intricacies of immune response and antigen presentation.

21 Sep 2023

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

A comprehensive review in Signal Transduction and Targeted Therapy delves into the versatility and effectiveness of mRNA vaccines, from their game-changing role in COVID-19 to potential applications in cancer and rare diseases. Despite drawbacks like stability and high immunogenicity, advancements in vaccine technology have poised mRNA platforms as a robust tool for both preventive and therapeutic interventions.

21 Sep 2023

Manipulating mitochondrial electron flow enhances immune response, reduces tumor growth

Immunotherapy, which uses the body's own immune system to fight cancer, is an effective treatment option, yet many patients do not respond to it.

21 Sep 2023

Study offers new insight into immune cells critical to successful vaccination against SARS-CoV-2

A study has revealed new details about a key population of immune system cells critical to successful vaccination against the pandemic virus, SARS-CoV-2.

21 Sep 2023

Study assesses duration of protection offered by smallpox infection and possible cross-reaction with Mpox virus

More than 43 years ago, many Chinese residents were vaccinated with the vaccinia virus Tiantan strain (VTT) to protect them from smallpox infection.

19 Sep 2023

New CAR T cell therapy approach minimizes severe side effects

In recent years, cancer researchers have hailed the arrival of chimeric antigen receptor T cell (CAR T) therapy, which has delivered promising results, transforming the fight against various forms of cancer. The process involves modifying patients' T-cells to target cancer cells, resulting in remarkable success rates for previously intractable forms of cancer.

19 Sep 2023

Unlocking the secret soldiers: How dendritic cells could revolutionize cancer immunotherapy

A recent review in the journal Immunity delves into the crucial role of dendritic cells (DCs) in shaping T-cell responses in cancer, highlighting their importance in both priming anti-tumor immunity and in ongoing immune interactions within tumors. The findings underscore the potential of DCs as key targets for next-generation cancer immunotherapies.

18 Sep 2023

Meridian Bioscience continues expansion of H. pylori diagnostic testing solutions with FDA clearance of premier HpSA flex

Meridian Bioscience, Inc., a leading global provider of diagnostic testing solutions and life science raw materials.

From Meridian Bioscience, Inc. 18 Sep 2023

How well do current vaccines hold up against new SARS-CoV-2 variants BA.2.86 and FLip?

The study explores the efficacy of three-dose monovalent or bivalent vaccinations in neutralizing newly emerged SARS-CoV-2 variants BA.2.86 and FLip. While BA.2.86 showed lower immune evasion abilities compared to recent XBB variants, it was less effectively neutralized by the monoclonal antibody S309, raising questions about vaccine efficacy against evolving strains.

17 Sep 2023

Phase 3 study: The efficacy of monovalent SARS-CoV-2 vaccine with AS03 adjuvant in adults

The effectiveness of a novel monovalent recombinant protein vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

15 Sep 2023

TU Dresden researchers develop highly innovative solutions for the detection of viral pathogens

The outbreak of the COVID pandemic in 2020 has once again shown how important reliable and rapid detection methods are to initiate effective measures to combat a pandemic.

14 Sep 2023

MIT study reveals why immunotherapy doesn't work for all cancer patients

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14 Sep 2023

Multi-omics study offers insights into psoriasis treatment

Researchers use a multi-omics approach combining immune cell-enriched scRNA-seq, microarray analysis, and immunohistochemistry to elucidate the translational role of anti-IL-17A in suppressing the autoimmune functions of T17 cells, thereby effectively treating human psoriasis.

14 Sep 2023

Reviving reservoirs: new findings shake up HIV treatment understanding

Researchers provide insight into the interaction between T lymphocytes and persisting reservoirs of HIV, with repercussions for harnessing effective, long-lasting responses to HIV eradication.

14 Sep 2023

A novel multi-epitope vaccine targeting extracellular proteins of Chlamydia pneumoniae

Researchers designed and evaluated a multi-epitope vaccine targeting the main outer membrane protein of Chlamydia pneumoniae using immunoinformatics.

14 Sep 2023

Oral SARS-CoV-2 vaccine shows promise in monkeys

A new paper in Biology Methods and Protocols, published by Oxford University Press, indicates that researchers studying SARS-CoV-2 may have developed new methods to administer vaccines orally, which would be both easier to administer and more effective at combatting illnesses.

13 Sep 2023

COVID-19 doubles risk of early type 1 diabetes signs in high-risk children

New research in JAMA finds a temporal association between SARS-CoV-2 infections and the onset of islet autoimmunity, a precursor to type 1 diabetes, in genetically predisposed infants. The study underscores COVID-19 as a potential risk factor for the development of this form of diabetes in young children.

13 Sep 2023

“Inverse vaccine” shows promise to reverse autoimmune diseases without shutting down rest of the immune system

A new type of vaccine developed by researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis, type 1 diabetes, and Crohn's disease -; all without shutting down the rest of the immune system.

12 Sep 2023

Antigen News and Research

Omics analysis identifies new biomarkers for predicting mortality in patients with pneumonia

Can COVID-19 vaccines turn the tide on long-haul symptoms?

CD1 lipidomes exhibit size-based antigen display mechanisms

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

Manipulating mitochondrial electron flow enhances immune response, reduces tumor growth

Study offers new insight into immune cells critical to successful vaccination against SARS-CoV-2

Study assesses duration of protection offered by smallpox infection and possible cross-reaction with Mpox virus

New CAR T cell therapy approach minimizes severe side effects

Unlocking the secret soldiers: How dendritic cells could revolutionize cancer immunotherapy

Meridian Bioscience continues expansion of H. pylori diagnostic testing solutions with FDA clearance of premier HpSA flex

How well do current vaccines hold up against new SARS-CoV-2 variants BA.2.86 and FLip?

Phase 3 study: The efficacy of monovalent SARS-CoV-2 vaccine with AS03 adjuvant in adults

TU Dresden researchers develop highly innovative solutions for the detection of viral pathogens

MIT study reveals why immunotherapy doesn't work for all cancer patients

Multi-omics study offers insights into psoriasis treatment

Reviving reservoirs: new findings shake up HIV treatment understanding

A novel multi-epitope vaccine targeting extracellular proteins of Chlamydia pneumoniae

Oral SARS-CoV-2 vaccine shows promise in monkeys

COVID-19 doubles risk of early type 1 diabetes signs in high-risk children

“Inverse vaccine” shows promise to reverse autoimmune diseases without shutting down rest of the immune system

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