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Researchers call for caution of using CAR-T immunotherapy against AML

Acute myeloid leukemia is a hematological malignancy which incidence increases with age, that is biologically, phenotypically, and genetically very heterogeneous.

17 Jun 2020

Integrin-binding peptide ATN-161: Potential COVID-19 treatment

Now, a new study by researchers at Tulane University and published on the preprint server bioRxiv* in June 2020 reports the potential role of an integrin inhibitor ATN-161 to prevent ACE2-S protein binding.

17 Jun 2020

Mapping RNA sequences of therapeutic value in the SARS-CoV-2 genome

Now, in new research published on the preprint server bioRxiv European scientists have performed RNA structure probing to obtain a single-base resolution secondary structure map of the full SARS-CoV-2 coronavirus genome.

17 Jun 2020

Novel ACE2-antibody fusion molecules show anti-SARS-CoV-2 activity

Now, in a new study published on the preprint server, bioRxiv researchers in the U.S. investigated a soluble version of ACE2 for SARS-CoV-2 viral neutralization activity.

17 Jun 2020

Scientists isolate powerful SARS-CoV-2 -neutralizing antibodies from COVID-19 patients

A new study has shown that potent antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could help protect against COVID-19 infection. Preliminary results in animal studies have so far proven successful. The study titled, "Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model," was published in the latest issue of the journal Science.

17 Jun 2020

Exposure to certain e-cig cartridges may cause fatal lung damage

Researchers at the University of Rochester Medical Center, New York, have shown that long-term exposure to certain electronic nicotine delivery systems (ENDS) may cause lung toxicity and injury among vapers.

16 Jun 2020

Depression and anxiety symptoms linked to changes in the brain's opioid system

A new study conducted in Turku, Finland, reveals how symptoms indicating depression and anxiety are linked to brain function changes already in healthy individuals.

16 Jun 2020

First National Preclinical Imaging Centre established in Ireland to enhance medical research

A new National Preclinical Imaging Centre which will provide enhanced research data to inform new clinical trials that aim to improve patient outcomes, has been awarded funding of €3.4 million under the Science Foundation Ireland Research Infrastructure Programme.

16 Jun 2020

Accelerating the Diagnosis and Treatment of Cancer with Mass-Spectrometry Based Techniques

An interview with Livia Eberlin, Assistant Professor at the University of Texas at Austin, discussing the development of mass-spectrometry based techniques for cancer diagnosis and improved clinical outcomes.

From Pittcon 16 Jun 2020

Inhaled steroids reduce ACE2 expression in COPD lungs

A new study by scientists at Imperial College London, University of Newcastle and Prokarium, and published on the preprint server bioRxiv* in June 2020 examines the role played by inhaled corticosteroids (ICS) in the risk of acquisition of COVID-19 infection by COPD patients.

15 Jun 2020

Hydroxychloroquine ineffective in animal SARS-CoV-2 infection

A new study by scientists from the U.S and U.K. and published on the preprint server bioRxiv in June 2020 reports that there is no evidence of efficacy for the drug hydroxychloroquine (HCQ) against infection with SARS-CoV-2 in hamsters or macaque models. This finding does not support the current widespread prophylactic and therapeutic use of HCQ in COVID-19.

14 Jun 2020

Hydroxychloroquine shows no antiviral effect on SARS-Cov-2 in non-human primate models

A study on the effects of hydroxychloroquinei n macaques infected with the SARS-CoV-2 virus, , used alone or in combination with azithromycin, have been pre-published on Research Square, after their submission to Nature.

12 Jun 2020

Inhibitory interneurons cause excitation in the developing brain

Brain function depends on inhibitory cells that balance or 'brake' excitation. These neurons allow the brain to process information and also prevent runaway seizures.

12 Jun 2020

Prodigiosin-based nanoformulation selectively disrupts cancer cells

Together with colleagues from the University of Palermo, KFU employees offer a nano preparation based on biocompatible halloysite nanotubes and bacterial pigment prodigiosin; the latter is known to selectively disrupt cancer cells without damaging the healthy ones.

12 Jun 2020

CELLINK collaborates with Lonza to advance complete 3D cell culture workflows

CELLINK has collaborated with Lonza to offer a comprehensive 3-dimensional (3D) bioprinting solution designed to advance complete 3D cell culture workflows.

From CELLINK 12 Jun 2020

Engineered natural killer cells show promise for treating a form of leukemia

Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells - a type of immune cell - with measurably stronger activity against a form of leukemia, both in vivo and in vitro.

12 Jun 2020

Transforming spleen to liver could bring new hope for patients suffering from organ shortage

Scientists from Nanjing University and University of Macau have transformed the spleen into a functioning liver in living mice, which could bring new hope for patients suffering from organ shortage worldwide.

11 Jun 2020

Turning autoimmunity drugs into anti-cancer treatments

Professor Mark Cragg speaks to News-Medical about his research which involves turning autoimmunity drugs into anti-cancer treatments.

11 Jun 2020

A lead compound can significantly reduce or eliminate toxoplasmosis and malaria

Toxoplasma gondii infection is one of the most frequent parasitic infections of humans. This parasite is present in the brain of an estimated two billion people--about 40 percent of all humans on earth. It is endemic throughout the world, causing water and food-borne epidemics that result in toxoplasmosis.

10 Jun 2020

The 2019 3Rs prize awarded to two pieces of novel research

The 2019 3Rs prize has been jointly awarded to Dr Francesca Nunn and Dr Marta Shahbazi for papers describing research that reduces the number of chickens and mice respectively. The 3Rs prize is awarded by the NC3Rs and sponsored by GSK.

10 Jun 2020