Mutation News and Research

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Antibiotic clofoctol shows potential against SARS-CoV-2

In a recent study, a group of French researchers aimed to reduce the regulatory preclinical development steps that potential candidates are normally subjected to.

5 Jul 2021

Study says mRNA COVID vaccines are effective against Lambda variant

Researchers in the United States have conducted a study suggesting that the coronavirus disease 2019 (COVID-19) vaccines that are currently being rolled out in many countries should be effective against the C.37 lineage (lambda variant) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 Jul 2021

Scientists identify natural SARS-CoV-2 super immunity against 23 variants

The antibodies are capable of neutralizing a wide range of SARS-CoV-2 variants even at sub-nanomolar concentrations. In addition, the combinations of these antibodies reduce the risk of generating escape mutants in vitro. The study is published in the journal Science.

5 Jul 2021

Researchers develop random priming amplification method for whole-genome sequencing of SARS-CoV-2 and H1N1

Researchers from the UK recently compared the performance of 4 different random priming amplification methods to recover SARS-CoV-2 RNA. In method 1 (H-P), the reverse transcriptase (RT) step included random hexamers, whereas, in methods 2-4, RT incorporated an octamer primer with a known tag. This study is published on the bioRxiv preprint server.

5 Jul 2021

Structure-guided T cell vaccine design could offer broad protection SARS-CoV-2 variants

Gaurav Gaiha, MD, DPhil, a member of the Ragon Institute of MGH, MIT and Harvard, studies HIV, one of the fastest-mutating viruses known to humankind.

2 Jul 2021

Mutations in the spike proteins of SARS-CoV-2 select for amino acid changes, increasing protein stability

A team of researchers recently demonstrated that mutations in the S protein of SARS-CoV-2 select for amino acid changes that result in a more stable protein than would otherwise be expected.

1 Jul 2021

Ion channel conserved in coronaviruses a potential new drug target for COVID therapeutics

To this end, a recent study published in Nature Structural & Molecular Biology discusses the structures of the SARS-CoV-2 ORF3a using cryo-electron microscopy (cryo-EM).

30 Jun 2021

Study highlights changes within SARS-CoV-2 variants that could be exploited to design effective inhibitors

A computational study that analyzes and explores the time-based structures of the SARS-CoV-2 variants with specific spike (S) protein mutations is discussed here.

30 Jun 2021

Reduced function of key gene may affect communication between motor neurons and muscles in ALS

Amyotrophic lateral sclerosis, or ALS, attacks nerve cells known as motor neurons in the brain and spinal cord, gradually leading to paralysis.

30 Jun 2021

Study uncovers common neural mechanism for cognitive impairment in autism and schizophrenia

Many neurodevelopmental disorders share similar symptoms, such as learning disabilities or attention deficits.

30 Jun 2021

Widespread SARS-CoV-2 mutation escapes vaccine- and infection-induced CD8 T-cell responses

Researchers in the UK have warned that a widespread mutation that has arisen in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to escape recognition by CD8 T-cell responses in both convalescent patients and recipients of the current coronavirus disease 2019 (COVID-19) vaccines.

29 Jun 2021

Findings suggest that the cross-linking of fibrin proteins is key to reducing blood clot formation

Researchers have found that the y cross-chain structure of fibrin proteins is essential to stabilizing blood clots that can lead to harmful embolism formation.

29 Jun 2021

H69/V70 deletion in Alpha variant enables SARS-CoV-2 to overcome chinks in its armor

One of the key mutations seen in the 'Alpha variant' of SARS-CoV-2 - the deletion of two amino acids, H69/V70 - enables the virus to overcome chinks in its armor as it evolves, say an international team of scientists.

29 Jun 2021

UPMC expert finds successful treatment for rare diseases diagnosed by newborn screenings

1It was a nagging mystery: A rare-disease expert at UPMC Children's Hospital of Pittsburgh had found a successful treatment for two of the deadliest symptoms of one of the more common classes of rare diseases diagnosed by newborn screenings, but one symptom--painful episodes of muscle breakdown that land victims in intensive care--persisted.

29 Jun 2021

Two CU Cancer Center studies provide insights into the link between inflammation and leukemia

Two recent collaborative publications by CU Cancer Center members provide insights into how chronic inflammation can serve as a key factor in the development of leukemia and other blood cancers.

29 Jun 2021

Study shows rapid expansion of SARS-CoV-2 Delta lineage in Ontario, Canada

A recent short report from Canada, currently available on medRxiv* preprint server, shows a rapid increase in severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) cases characterized by the N501Y-/E484K- mutation in the Ontario province, which implies that Delta variant will rapidly overtake the Alpha variant.

28 Jun 2021

Novel approach to molecular drug design paves way for promising bladder cancer therapy

A new approach to molecular drug design has yielded a highly promising bladder cancer drug, which induced rapid shedding of tumor cells and resulted in a significant reduction in tumour size when used in clinical trials.

28 Jun 2021

IR imaging-based AI offers a label-free and automated approach to identify lung tumor types

Infrared spectroscopy can automatically distinguish between various types of lung cancer and genetic mutations, allowing quick and reliable statements to be made regarding prognosis and treatment decisions.

28 Jun 2021

Vaccines and drugs must be adapted to combat emerging SARS-CoV-2 variants, says study

A new review of the emerging variants of concern (VOCs) of the SARS-CoV-2, which has caused the COVID-19 pandemic, shows that there is a major need to constantly re-evaluate the utility of existing therapeutics and vaccines against the virus and to develop new ones.

28 Jun 2021

Mutation-signature–associated metrics predict cancer progression in patients

Oncotarget published "Predicting clinical outcomes using cancer progression associated signatures" which reported somatic mutation signatures are an informative facet of cancer etiology, however they are rarely useful for predicting patient outcome.

28 Jun 2021

Mutation News and Research

Antibiotic clofoctol shows potential against SARS-CoV-2

Study says mRNA COVID vaccines are effective against Lambda variant

Scientists identify natural SARS-CoV-2 super immunity against 23 variants

Researchers develop random priming amplification method for whole-genome sequencing of SARS-CoV-2 and H1N1

Structure-guided T cell vaccine design could offer broad protection SARS-CoV-2 variants

Mutations in the spike proteins of SARS-CoV-2 select for amino acid changes, increasing protein stability

Ion channel conserved in coronaviruses a potential new drug target for COVID therapeutics

Study highlights changes within SARS-CoV-2 variants that could be exploited to design effective inhibitors

Reduced function of key gene may affect communication between motor neurons and muscles in ALS

Study uncovers common neural mechanism for cognitive impairment in autism and schizophrenia

Widespread SARS-CoV-2 mutation escapes vaccine- and infection-induced CD8 T-cell responses

Findings suggest that the cross-linking of fibrin proteins is key to reducing blood clot formation

H69/V70 deletion in Alpha variant enables SARS-CoV-2 to overcome chinks in its armor

UPMC expert finds successful treatment for rare diseases diagnosed by newborn screenings

Two CU Cancer Center studies provide insights into the link between inflammation and leukemia

Study shows rapid expansion of SARS-CoV-2 Delta lineage in Ontario, Canada

Novel approach to molecular drug design paves way for promising bladder cancer therapy

IR imaging-based AI offers a label-free and automated approach to identify lung tumor types

Vaccines and drugs must be adapted to combat emerging SARS-CoV-2 variants, says study

Mutation-signature–associated metrics predict cancer progression in patients

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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