Cardiometabolic News and Research

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Healthy lifestyle habits plus GLP-1 RA drugs can improve heart health of people with Type 2 diabetes

People with Type 2 diabetes who combined healthy lifestyle habits with GLP-1 receptor agonist (GLP-1 RA) medications had a greater reduction in risk of major adverse cardiovascular events, including heart attack, stroke or cardiovascular disease death, compared to people only taking the medication, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2025.

3 Nov 2025

Scientists uncover new obesity genes that reshape understanding of weight and disease risk

Researchers identified five previously unknown genes linked to obesity by analyzing rare protein-truncating variants across six ancestries. The study reveals how rare and common genetic factors combine to influence BMI and related diseases like diabetes and heart failure.

2 Nov 2025

New evidence-based points to consider and consensus definitions for people with psoriatic arthritis

Some people with psoriatic arthritis (PsA) may have disease that is difficult to manage (D2M) or does not respond to treatment. EULAR - The European Alliance of Associations for Rheumatology - has released new evidence-based points to consider and consensus definitions for these groups.

30 Oct 2025

Does fasting earlier in the day improve metabolism? This study says no

In a randomized crossover trial of 31 women with overweight, early and late time-restricted eating (TRE) produced no improvement in insulin sensitivity or cardiometabolic markers under isocaloric conditions. Both schedules, however, shifted internal circadian clocks, highlighting that meal timing affects biological rhythms more than metabolic outcomes.

30 Oct 2025

Aligning your body clock may protect your heart and metabolism, says AHA

A new American Heart Association scientific statement highlights how maintaining circadian health through regular sleep, light exposure, meal timing, and exercise may reduce cardiometabolic disease risk. Disrupting these daily rhythms can impair glucose regulation, blood pressure, and cardiovascular function.

29 Oct 2025

Circadian rhythm disruptions may increase the risk of cardiovascular disease

As modern lifestyles increasingly challenge the body's natural circadian rhythm, the American Heart Association is spotlighting the potential health consequences of regular disruptions to our body's internal clock with a new scientific statement published today in its flagship journal Circulation.

28 Oct 2025

Study finds bright nights raise risk for stroke and heart failure in adults over 40

A large UK Biobank study found that higher night-time light exposure is linked to significantly greater risks of coronary artery disease, stroke, heart failure, and other cardiovascular conditions. The findings suggest maintaining darker nights and adequate daytime light could support heart health.

26 Oct 2025

What Britain’s post-war sugar rationing teaches us about long-term heart health

A BMJ study found that individuals exposed to sugar rationing during their first 1,000 days of life had significantly lower risks of heart attack, stroke, and heart failure in adulthood. Early-life sugar restriction was linked to a 2.5-year delay in cardiovascular disease onset, suggesting long-term benefits for heart health.

26 Oct 2025

Are ultra-processed plant foods really worse than meat? Scientists weigh in

A new review challenges assumptions about ultra-processed foods, finding that plant-based versions, such as soymilk, meat analogs, and soft margarines, may lower cholesterol and disease risk compared with unprocessed animal foods when used as replacements.

26 Oct 2025

Semaglutide can offer important heart benefits that go beyond weight loss

A new analysis of the SELECT trial – the largest and longest clinical trial to date examining the cardiovascular benefits of semaglutide (a medication used to support weight loss and diabetes management) – confirms it also lowers the risk of major heart problems in people who are overweight or obese and already have heart disease, even if they don't have diabetes.

23 Oct 2025

Analysis highlights the differing physical side effects of antidepressants

Antidepressants can differ widely in how they physically affect the body, including around a 4 kg difference in weight change between certain drugs (approximately 2.5 kg weight loss from agomelatine and 2kg weight gain from maprotiline), confirms a systematic review and meta-analysis published in The Lancet.

22 Oct 2025

Early menopause increases risk of metabolic syndrome in women

The prevalence of metabolic syndrome, a dangerous and potentially deadly condition, increases with menopause.

21 Oct 2025

Baby's birthweight increases risk of cardiovascular disease in preeclamptic and hypertensive women

A new study shows that preeclamptic and hypertensive pregnant women's risk of getting cardiovascular disease is linked to their baby's birthweight.

21 Oct 2025

Transdermal hormone therapy offers potential reduction in anxiety and depression

Hormone therapy–oral and transdermal–remains the most effective treatment for such bothersome menopause symptoms as hot flashes and is generally considered safe for most patients. A new study shows that risk profiles are different based on how the hormones are administered.

21 Oct 2025

Social and environmental inequality linked to risk of Alzheimer’s

The study uncovers links between neighborhood disadvantage and Alzheimer's biomarkers, stressing the importance of addressing social inequalities in healthcare.

20 Oct 2025

MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer

Researchers developed seven MRI-based biological age clocks across major organs using UK Biobank imaging, linking each to proteins, metabolites, genetics, disease risks, mortality, and cognitive decline. These organ-specific age gaps reveal how uneven aging shapes vulnerability to conditions such as diabetes, hypertension, and dementia, opening new paths for precision prevention and clinical trial stratification

19 Oct 2025

People's heart health unlikely to be affected by some industrially processed hard fats

Two types of industrially processed hard fats, widely used in everyday foods such as bakery products, margarines and spreads, are unlikely to affect heart health when consumed in levels achievable in most people's diets.

17 Oct 2025

Why improving LE8 scores could save young adults from diabetes

Young adults with prediabetes who maintained higher Life’s Essential 8 (LE8) cardiovascular health scores were far less likely to progress to type 2 diabetes over 13 years. Ideal LE8 profiles, particularly healthy weight, blood pressure, physical activity, and sleep, were strongly associated with regression to normal glucose levels.

14 Oct 2025

Skipping breakfast raises metabolic syndrome risk

Research shows that skipping breakfast increases the risk of metabolic syndrome, emphasizing the need for a nutritious morning meal to support long-term health.

13 Oct 2025

Study reveals distinct links between depression subtypes and metabolic diseases

It is known that depression is linked to increased incidence of metabolic diseases; now scientists have discovered that different types of depression are linked to different cardiometabolic diseases. This work is presented at the ECNP Congress in Amsterdam.

12 Oct 2025

Cardiometabolic News and Research

Healthy lifestyle habits plus GLP-1 RA drugs can improve heart health of people with Type 2 diabetes

Scientists uncover new obesity genes that reshape understanding of weight and disease risk

New evidence-based points to consider and consensus definitions for people with psoriatic arthritis

Does fasting earlier in the day improve metabolism? This study says no

Aligning your body clock may protect your heart and metabolism, says AHA

Circadian rhythm disruptions may increase the risk of cardiovascular disease

Study finds bright nights raise risk for stroke and heart failure in adults over 40

What Britain’s post-war sugar rationing teaches us about long-term heart health

Are ultra-processed plant foods really worse than meat? Scientists weigh in

Semaglutide can offer important heart benefits that go beyond weight loss

Analysis highlights the differing physical side effects of antidepressants

Early menopause increases risk of metabolic syndrome in women

Baby's birthweight increases risk of cardiovascular disease in preeclamptic and hypertensive women

Transdermal hormone therapy offers potential reduction in anxiety and depression

Social and environmental inequality linked to risk of Alzheimer’s

MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer

People's heart health unlikely to be affected by some industrially processed hard fats

Why improving LE8 scores could save young adults from diabetes

Skipping breakfast raises metabolic syndrome risk

Study reveals distinct links between depression subtypes and metabolic diseases

Advances in cardiometabolic research and clinical trial design eBook

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