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Genetic marker linked to higher risk of death in COVID-19 patients

A new study discusses the importance of single nucleotide polymorphisms in the Rab46 gene as a marker of adverse outcomes in high-risk COVID-19 patients.

23 Jan 2022

Study suggests myeloid cell dysregulation is a driver of COVID-19 severity

Researchers determine the driving factors for disease severity and death due to COVID-19.

17 Jan 2022

The unique T cell response elicited by SARS-CoV-2 during a primary immune response by infection and vaccination

The distinctive characteristics of the T cell response generated by SARS-CoV-2 infection and vaccination and the relationship to CCCoVs and VOC was explored in a review published in Frontiers in Medicine.

13 Jan 2022

Withdrawing steroid treatment found to boost SARS-CoV-2 vaccine-induced immunity in kidney transplant recipients

In a new study, a team of researchers investigated the impact of the fourth dose of a vaccine against COVID-19 in kidney transplant recipients, who had not mounted a humoral immune response to three doses of vaccine.

11 Jan 2022

New approach could offer a more accurate way to evaluate donor kidney quality

A new way to evaluate the quality of kidneys before transplantation could one day help increase the number of usable donor kidneys.

5 Jan 2022

Researchers compare survival rates of AML patients treated with two forms of transplantation methods

Acute myeloid leukemia (AML) is a common type of blood cancer that has a relatively low survival rate. It is particularly deadly for patients suffering from refractory and relapsed AML (R/R AML), meaning their cancer has stopped responding to treatment and has returned after a period of remission.

5 Jan 2022

SARS-CoV-2 spike T cell responses from vaccines or infection remain robust against Omicron

In a new study, a team of researchers from multi-national institutions discovered that 70-80% of CD4 and CD8 T cell responses to spike were consistent across research groups. Moreover, although having far more mutations, the magnitude of Omicron cross-reactive T cells was comparable to that of the Beta and Delta variants.

3 Jan 2022

Third BNT162b2 dose effectively neutralizes SARS-CoV-2 Omicron pseudovirus

The findings reveal that the Omicron neutralizing titers induced by the third vaccine dose are comparable to that achieved against the original Wuhan strain (wild-type SARS-CoV-2) by the two-dose regimen. The study is currently available on the medRxiv* preprint server while awaiting peer review.

28 Dec 2021

Impact of acute kidney injury associated gene expression in human kidney cells

A new study attempts to perform a comparative single-cell census of human kidneys employing samples from individuals suffering from acute kidney injury and controls without the condition.

20 Dec 2021

Investigating potential cross-protection against SARS-CoV-2 after previous exposure to bovine coronavirus

Researchers have conducted an investigation to probe the similarity of viral epitopes between bovine coronavirus (BCoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Dec 2021

T cell responses remain broadly robust against Omicron variant of SARS-CoV-2

A new study highlights the significance of robust T cell responses in preventing severe omicron infections.

16 Dec 2021

T-cell immune response in previously infected and vaccinated individuals effective against SARS-CoV-2 Omicron variant

New findings illustrate that despite the continuous pattern of the ongoing evolution of SARS-CoV-2, it has not resulted in any significant accumulation of CD8+ T-cell escape mutations.

15 Dec 2021

COVID-19 in association with pre-existing mental and physical health issues

The present study attempts to identify the factors that increase the risk of COVID-19 infection or confer protection against COVID-19 in a study population above 55 years of age known to experience higher morbidity and risk of mortality from COVID-19.

13 Dec 2021

New approach to COVID-19 immune profiling using blood-based machine learning

A new study discusses the application of a novel deconvolution model AImmune to predict moderate and severe cases of COVID-19.

5 Dec 2021

Maternal-fetal interface yields intriguing clues to how it battles SARS-CoV-2

Scientists have hypothesized that the number of immune cells and the amount of cytokines produced in response to SARS-CoV-2 infection in pregnant women change in accordance with the timing of maternal infection in pregnancy. This study is available on the bioRxiv* preprint server.

24 Nov 2021

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

A new study, published on the bioRxiv* preprint server, has focused on public clonotypes, i.e., clones found in multiple individuals, for the development of a novel reverse epitope discovery technique. This technique holds greater potential for population-wide applications.

23 Nov 2021

What genes affect the COVID-19 gender imbalance?

Many studies have established that coronavirus disease 2019 (COVID-19) is more infective in men than women, and men are more at risk of severe disease. While some have suggested that behavioral differences could explain increased transmission to men, this does not explain the more morbid prognosis.

16 Nov 2021

Leukocyte News and Research

Genetic marker linked to higher risk of death in COVID-19 patients

Study suggests myeloid cell dysregulation is a driver of COVID-19 severity

The unique T cell response elicited by SARS-CoV-2 during a primary immune response by infection and vaccination

Withdrawing steroid treatment found to boost SARS-CoV-2 vaccine-induced immunity in kidney transplant recipients

New approach could offer a more accurate way to evaluate donor kidney quality

Researchers compare survival rates of AML patients treated with two forms of transplantation methods

SARS-CoV-2 spike T cell responses from vaccines or infection remain robust against Omicron

Third BNT162b2 dose effectively neutralizes SARS-CoV-2 Omicron pseudovirus

Impact of acute kidney injury associated gene expression in human kidney cells

Investigating potential cross-protection against SARS-CoV-2 after previous exposure to bovine coronavirus

T cell responses remain broadly robust against Omicron variant of SARS-CoV-2

T-cell immune response in previously infected and vaccinated individuals effective against SARS-CoV-2 Omicron variant

COVID-19 in association with pre-existing mental and physical health issues

New approach to COVID-19 immune profiling using blood-based machine learning

Maternal-fetal interface yields intriguing clues to how it battles SARS-CoV-2

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

What genes affect the COVID-19 gender imbalance?

What are the anti-COVID drugs currently in development?

Study finds SARS-CoV-2 infection of endothelial cells unlikely

Study assesses T-cell responses directed against highly conserved regions of SARS-CoV-2

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