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Decoding nucleic acid-based drugs and vaccines through SEC-SLS analysis

In this interview, Malvern Panalytical’s Product Technical Specialist, Stefan Cairns, discusses how SEC-SLS can be used to understand MRNA vector composition by referencing his latest publication.

From Malvern Panalytical 19 Dec 2022

Study shows how a specific gut microbe-generated byproduct is linked to heart failure risk

New research at Cleveland Clinic expands the link between what we eat and how the gut microbiome impacts our susceptibility to develop different diseases – in this case, how a specific gut microbe-generated byproduct is linked to heart failure risk.

16 Dec 2022

NEJM study shows hidden genetic anomaly behind common late-onset cerebellar ataxia

Researchers at the University of Miami Miller School of Medicine, McGill University and other institutions have found that a well-concealed genetic variation in the gene FGF14, called a DNA tandem repeat expansion, causes a common form of late-onset cerebellar ataxia, a brain disorder that interferes with coordinated movement.

16 Dec 2022

Study uncovers new immune target to treat atherosclerosis

For the longest time, clinicians have treated cardiovascular disease by focusing on diabetes and blood pressure control, reducing cholesterol using medications like aspirin and statins.

16 Dec 2022

Assessing clinical adoption of 2017 guidelines for interpretation and reporting of sequence variants in cancer

The Association for Molecular Pathology (AMP), the premier global molecular diagnostic professional society, has published a report that was designed to assess clinical adoption, identify classification inconsistencies, and evaluate implementation barriers for the 2017 report, "Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.

15 Dec 2022

What is the role of the pediatric gut microbiome in COVID-19?

Recently, scientists have reviewed the available evidence on the gut microbiome in children with COVID-19 and published it in Microorganisms.

15 Dec 2022

No benefit of low dose apixaban following acute COVID-19

The HEAL-COVID trial compared the efficacy of Apixaban to standard care in adults who have recently recovered from severe COVID-19.

14 Dec 2022

Study finds a novel therapeutic target for prevention and treatment of gout

Many Americans think of gout as a disease from a bygone era, akin to rickets or scurvy. The condition commonly afflicted the rich and royal, including American historical figures such as Benjamin Franklin and Thomas Jefferson.

14 Dec 2022

How human cell atlases provide the missing links between genes, diseases and therapies

A Nature Medicine journal perspective article describes the potential of cell atlases in shaping the future of medicine. Providing the missing link between genes and diseases, single-cell atlases make it possible to develop more precise and specific diagnostic tools by understanding the mechanisms of complex diseases.

12 Dec 2022

Study: Only 30% of people with neuroendocrine tumors consider living longer as top priority

New research from cancer research and treatment organization City of Hope in the December 2022 issue of JNCCN - Journal of the National Comprehensive Cancer Network finds that only 30% of patients with advanced neuroendocrine tumors (NETs) say their top goal for treatment is living longer.

12 Dec 2022

Study illustrates the importance of getting outside during the day, even when it’s cloudy

A study measuring the sleep patterns of students at the University of Washington has turned up some surprises about how and when our bodies tell us to sleep - and illustrates the importance of getting outside during the day, even when it's cloudy.

12 Dec 2022

A-HIPI decision model can predict survival in adults with advanced-stage Hodgkin lymphoma

Investigators from Rutgers Cancer Institute of New Jersey, the state's only NCI-designated Comprehensive Cancer Center and leading cancer program along with Tufts Medical Center in Boston, developed and validated the Advanced-stage Hodgkin lymphoma International Prognostication Index (A-HIPI).

12 Dec 2022

How convergent evolution is creating new COVID-19 waves

Researchers detail the unique evolutionary trajectory of SARS-CoV-2, with a focus on its unprecedented scale in 2022.

11 Dec 2022

Study shows how an inflammatory molecule causes life-threatening airway damage in asthma patients

An inflammatory molecule called LIGHT, appears to be the cause of life-threatening airway damage in patients with severe asthma.

9 Dec 2022

Researchers discover a previously unknown mechanism that drives aging

Northwestern University researchers have discovered a previously unknown mechanism that drives aging.

9 Dec 2022

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

A fundamental challenge in drug development is the balance between optimizing a drug's lock-and-key fit with its target and the drug's ability to make its way across the cellular membrane and access that target.

8 Dec 2022

Trial establishes the clinical utility of circulating tumor cell count as biomarker in breast cancer care

The use of circulating tumor cell (CTC) count to guide the choice between chemotherapy and endocrine therapy as first-line therapy for patients with metastatic, estrogen receptor (ER)-positive/HER2-negative breast cancer provided overall survival benefit, compared with physician's choice of treatment, according to data from the STIC CTC trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

8 Dec 2022

T-DXd leads to longer overall survival in HER2-positive metastatic breast cancer patients than T-DM1

Second-line treatment with trastuzumab deruxtecan (T-DXd) led to significantly longer overall survival compared with trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer, according to updated results from the DESTINY-Breast03 phase III clinical trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Patients with localized, hormone receptor-positive, HER2-low breast cancer treated with trastuzumab deruxtecan (T-DXd, Enhertu) in the neoadjuvant setting had an overall response rate of 75 percent in the absence of anastrozole and 63 percent in combination with anastrozole, according to results from the phase II TRIO-US B-12 TALENT trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

Study reveals biological mechanism to explain why respiratory viruses spike in colder seasons

Researchers at Mass Eye and Ear and Northeastern University have discovered a previously unidentified immune response inside the nose that fights off viruses responsible for upper respiratory infections.

7 Dec 2022

Therapeutics News and Research

Decoding nucleic acid-based drugs and vaccines through SEC-SLS analysis

Study shows how a specific gut microbe-generated byproduct is linked to heart failure risk

NEJM study shows hidden genetic anomaly behind common late-onset cerebellar ataxia

Study uncovers new immune target to treat atherosclerosis

Assessing clinical adoption of 2017 guidelines for interpretation and reporting of sequence variants in cancer

What is the role of the pediatric gut microbiome in COVID-19?

No benefit of low dose apixaban following acute COVID-19

Study finds a novel therapeutic target for prevention and treatment of gout

How human cell atlases provide the missing links between genes, diseases and therapies

Study: Only 30% of people with neuroendocrine tumors consider living longer as top priority

Study illustrates the importance of getting outside during the day, even when it’s cloudy

A-HIPI decision model can predict survival in adults with advanced-stage Hodgkin lymphoma

How convergent evolution is creating new COVID-19 waves

Study shows how an inflammatory molecule causes life-threatening airway damage in asthma patients

Researchers discover a previously unknown mechanism that drives aging

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

Trial establishes the clinical utility of circulating tumor cell count as biomarker in breast cancer care

T-DXd leads to longer overall survival in HER2-positive metastatic breast cancer patients than T-DM1

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Study reveals biological mechanism to explain why respiratory viruses spike in colder seasons

Event guide: The Non-Opioid Pain Therapeutics Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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