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Modified blood thinner may be first promising method to prevent repercussions after TBI

A chemically modified version of the common blood thinner heparin may be the first promising method of preventing the harmful cascade of destruction to brain tissue that commonly follows traumatic brain injury (TBI), according to new research findings.

13 Sep 2017

Researchers overcome major stumbling blocks in developing HIV vaccine

An international team of researchers has demonstrated a way of overcoming one of the major stumbling blocks that has prevented the development of a vaccine against HIV: the ability to generate immune cells that stay in circulation long enough to respond to and stop virus infection.

13 Sep 2017

Combination immunotherapy shows better overall survival in kidney cancer patients

A combination immunotherapy treatment showed better overall survival in patients with previously untreated advanced or metastatic renal cell carcinoma than current therapy, according to results from a phase 3 clinical trial presented at the Presidential Symposium of the European Society for Medical Oncology's 2017 Congress in Spain.

13 Sep 2017

Arkansas professor makes strides toward developing enhanced cancer treatment

A University of Arkansas at Little Rock professor is making strides toward developing an effective cancer treatment without the severe side effects of traditional therapies.

13 Sep 2017

Multigene panel test could be useful to detect patients with hereditary kidney cancer syndrome

A multigene panel test could be a useful diagnostic tool to help clinicians identify patients with a hereditary kidney cancer syndrome, according to the results of a study published in Cancer.

13 Sep 2017

Disrupting DNA loops could be potential strategy to reduce tumor proliferation

The discovery of a mechanism by which normal brain cells regulate the expression of the NFIA gene, which is important for both normal brain development and brain tumor growth, might one day help improve therapies to treat brain tumors. The study appears in the journal Nature Neuroscience.

13 Sep 2017

NIH grant supports temple researchers' exploration of stem cell-based treatments for heart repair

The incidence of heart disease is on the rise, and new therapeutic strategies are needed. Approaches based on stem cells, which can potentially preserve or even regenerate heart muscle cells damaged by ischemia - a hallmark of heart disease - are especially promising.

13 Sep 2017

MGH researchers identify potential strategy for improving efficacy of angiogenesis inhibitors

A Massachusetts General Hospital research team has identified a potential strategy for improving the efficacy of angiogenesis inhibitors, drugs that help fight cancer by blocking the formation of new blood vessels.

13 Sep 2017

New testing regime could speed up diagnosis and treatment of SCID in infants

Babies born with Severe Combined Immune Deficiency (SCID) syndrome are defenceless against bacterial and viral infections that would be virtually harmless to most healthy people. If untreated, SCID is often fatal within a baby's first year of life.

13 Sep 2017

New research uncovers 17 new genetic variants linked to Parkinson’s disease

In the UK, every hour someone receives the devastating news that they have Parkinson’s disease. One in every 500 people suffers from Parkinson's, which equates to approximately 127,000 people across the UK. The majority of those diagnosed with Parkinson's are aged over 50, but for many, it will begin far earlier. There is currently no cure.

13 Sep 2017

Japanese researchers find new way for increasing effectiveness of drug delivery to brain tumors

For a cancer drug to be successful, it needs to reach the malignant tumor site. Researchers in Japan have now found a way for increasing the effectiveness of drug delivery to certain types of brain tumors, by packing epirubicin, a known antitumor agent, in specially designed polymeric micelles.

13 Sep 2017

Scientists use novel microscopy to illuminate chromosomal 'dark matter'

Using a microscope invented at the Marine Biological Laboratory (MBL), a collaborative team of biologists, instrument developers, and computational scientists has for the first time measured the density of a relatively inscrutable, highly condensed form of chromosomal material that appears in the cells of human beings and other eukaryotes.

13 Sep 2017

PCORI Board awards $18 million for two new studies on sickle cell disease

The Patient-Centered Outcomes Research Institute Board of Governors today approved about $18 million to fund two studies comparing different ways to manage the transition of people with sickle cell disease from pediatric to adult care.

13 Sep 2017

NIH awards $15 million to develop 3D microphysiological system platforms that model human disease

More than 60 percent of investigational drugs fail in human clinical trials due to a lack of effectiveness, despite promising pre-clinical studies using cell and animal research models.

13 Sep 2017

Researchers develop fluorescent sensors for detecting, tracking GTP levels in living cells

For several decades, scientists have recognized the key role that a molecule known as GTP, one of the building blocks of RNA, plays in the development of cancer and other diseases.

13 Sep 2017

Research uncovers new target for therapy, diagnosis, and prognosis of colon cancer

Genetic research conducted at LSU Health New Orleans School of Medicine and Stanley S. Scott Cancer Center demonstrated for the first time that a novel protein can cause normal cells in the lining of the colon to become malignant, grow and spread, as well as take on the characteristics of stem cells.

12 Sep 2017

Epigenetic changes triggered by cigarette smoke may be earliest step in lung cancer development

Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory-grown, human airway cells that a condensed form of cigarette smoke triggers so-called "epigenetic" changes in the cells consistent with the earliest steps toward lung cancer development.

12 Sep 2017

Phthalate levels in expectant fathers influence sperm epigenetics, study suggests

Early results from a larger, ongoing study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst suggest that phthalate levels in expectant fathers have an effect on couples' reproductive success via epigenetic modifications of sperm DNA.

12 Sep 2017

Researchers set new delivery distance record for medical drones

Johns Hopkins researchers have set a new delivery distance record for medical drones, successfully transporting human blood samples across 161 miles of Arizona desert. Throughout the three-hour flight, they report, the on-board payload system maintained temperature control, ensuring the samples were viable for laboratory analysis after landing.

12 Sep 2017

Chemists examine radioactive metal complexes for tumor diagnosis and treatment

A team under the direction of chemist Prof. Dr Peter Comba is investigating radioactive metal complexes for use in the diagnosis and treatment of tumors.

12 Sep 2017

B Cell News and Research

Modified blood thinner may be first promising method to prevent repercussions after TBI

Researchers overcome major stumbling blocks in developing HIV vaccine

Combination immunotherapy shows better overall survival in kidney cancer patients

Arkansas professor makes strides toward developing enhanced cancer treatment

Multigene panel test could be useful to detect patients with hereditary kidney cancer syndrome

Disrupting DNA loops could be potential strategy to reduce tumor proliferation

NIH grant supports temple researchers' exploration of stem cell-based treatments for heart repair

MGH researchers identify potential strategy for improving efficacy of angiogenesis inhibitors

New testing regime could speed up diagnosis and treatment of SCID in infants

New research uncovers 17 new genetic variants linked to Parkinson’s disease

Japanese researchers find new way for increasing effectiveness of drug delivery to brain tumors

Scientists use novel microscopy to illuminate chromosomal 'dark matter'

PCORI Board awards $18 million for two new studies on sickle cell disease

NIH awards $15 million to develop 3D microphysiological system platforms that model human disease

Researchers develop fluorescent sensors for detecting, tracking GTP levels in living cells

Research uncovers new target for therapy, diagnosis, and prognosis of colon cancer

Epigenetic changes triggered by cigarette smoke may be earliest step in lung cancer development

Phthalate levels in expectant fathers influence sperm epigenetics, study suggests

Researchers set new delivery distance record for medical drones

Chemists examine radioactive metal complexes for tumor diagnosis and treatment

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