Preclinical News and Research

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First-of-its-kind synthetic DNA vaccine designed against Powassan virus

Scientists at The Wistar Institute have designed and tested the first-of-its-kind synthetic DNA vaccine against Powassan virus (POWV), targeting portions of the virus envelope protein.

30 Oct 2020

New therapeutic approach brings hope for treating psoriasis

Disruptive innovations in psoriasis are leading the way at EADV's 29th Congress, EADV Virtual. New data published today shows the first clinical evidence of modulating systemic inflammation by oral delivery of a non-living single strain commensal microbe.

29 Oct 2020

New method could help increase effectiveness of vaccines against coronavirus

A University at Buffalo-led research team has discovered a technique that could help increase the effectiveness of vaccines against the novel coronavirus, the virus that causes COVID-19.

29 Oct 2020

Researchers discuss emerging applications of AI in preclinical and clinical medicine

Announcing a new article publication for BIO Integration journal. In this review article the authors Chenxi Liu, Dian Jiao and Zhe Liu, from Tianjin University, Tianjin, China consider artificial intelligence (AI) aided disease prediction.

29 Oct 2020

Deep learning models help hunt for COVID-19 drugs

Michigan State University Foundation Professor Guowei Wei wasn't preparing machine learning techniques for a global health crisis. Still, when one broke out, he and his team were ready to help.

28 Oct 2020

Research details new strategy for overcoming treatment resistance by zeroing in on dendritic cells

Many of the most aggressive and hard-to-treat cancers are highly effective at blocking T cells, known as the foot soldiers of the immune system, from reaching and responding to tumors.

27 Oct 2020

Advancements in research on cancer signal transduction and treatment

Cancer is driven by numerous genetic and epigenetic changes occurring at the cellular level. These changes drive normal cells to proliferate and escape processes that usually regulate their survival and migration.

27 Oct 2020

Powerful drug used in chemotherapy could alleviate hallucinations in Parkinson's patients

A world-first double-blind clinical trial, will investigate if a powerful drug used to treat nausea in chemotherapy patients, could alleviate hallucinations in people with Parkinson's.

27 Oct 2020

Study finds new transposon-derived genes related to autism

The lack of some genes in the BEC/TCEAL cluster could be related to some alterations associated with the autism spectrum disorder, according to a preclinical study published in the journal Genome Biology, and led by Professor Jordi Garcia Fernàndez, from the Faculty of Biology and the Institute of Biomedicine of the University of Barcelona, and researcher Jaime Carvajal, from the Andalusian Centre for Developmental Biology - University Pablo de Olavide.

27 Oct 2020

Age can affect response to adjuvant treatment among patients with resected melanoma

Younger patients with resected melanoma had some benefit from adjuvant treatment with the anti-VEGF therapeutic bevacizumab (Avastin) while older patients with resected melanoma did not

23 Oct 2020

DNA vaccine-induced antibodies neutralize SARS-CoV-2

The coronavirus disease (COVID-19) is far from over as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to ravage across the globe. With the vast spread of the virus, many countries who reported flattening the curve over the past months have reported clusters of new cases and second waves of the outbreak.

22 Oct 2020

UCLA researchers discover compound that stimulates muscle cells in mice

UCLA researchers have identified a compound that can reproduce the effect of exercise in muscle cells in mice. The findings are published in the journal Cell Reports Medicine.

21 Oct 2020

New vaccine targeting toxic Aβ may offer clinical benefit in treating Alzheimer's disease

Our immune system's capacity to mount a well-regulated defense against foreign substances, including toxins, weakens with age and makes vaccines less effective in people over age 65.

20 Oct 2020

Anti-inflammatory therapy helps slow progression of multiple sclerosis in a preclinical model

Intranasal administration of an anti-inflammatory drug helped reduce disease progression in a preclinical model of multiple sclerosis, according to recent research out of the University of Alberta.

20 Oct 2020

Study findings may help identify new targets to inhibit spread of melanoma

Research led by Queen Mary University of London has revealed novel insights into the mechanisms employed by melanoma cells to form tumors at secondary sites around the body.

20 Oct 2020

Adult stem cell-based lung organoid models emulate host immune response in fatal COVID-19

Recently, a team of researchers from the University of California San Diego and The Scripps Research Institute, CA, USA, showed that an integrated stem cell-based disease modeling and computational approach is crucial for simulating the host immune response in fatal COVID-19 patients.

19 Oct 2020

Promising interim results for Sinopharm's inactivated whole-virion SARS-CoV-2 vaccine

The COVID-19 pandemic has led to intensive scientific efforts to bring about an effective vaccine for global distribution. Many different vaccine design approaches are underway. A recent study published in the journal The Lancet Infectious Diseases in October 2020 reports a potentially successful inactivated virus vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

19 Oct 2020

Cleveland Clinic joins new Center for Integrated Multi-Modal and Multi-Scale Nucleome Research

Cleveland Clinic has been named a participating institution for the newly established Center for Integrated Multi-Modal and Multi-Scale Nucleome Research, made possible by a recently awarded five-year, $6.5 million consortium grant from the National Institutes of Health Common Fund.

19 Oct 2020

Patients with congenital heart defects have lower risk of severe COVID-19 symptoms

Adults and children born with heart defects had a lower-than-expected risk of developing moderate or severe COVID-19 symptoms, finds a study of more than 7,000 patients from the congenital heart disease center at Columbia University Vagelos College of Physicians and Surgeons.

19 Oct 2020

Antispastic drug candidate could offer new hope for millions of patients suffering from spasticity

First-in-class antispastic drug candidate to reach clinical phase is published in the prestigious life science journal, Cell. Drug candidate MPH-220 could mean new hope for millions of patients suffering from spasticity.

16 Oct 2020

Preclinical News and Research

First-of-its-kind synthetic DNA vaccine designed against Powassan virus

New therapeutic approach brings hope for treating psoriasis

New method could help increase effectiveness of vaccines against coronavirus

Researchers discuss emerging applications of AI in preclinical and clinical medicine

Deep learning models help hunt for COVID-19 drugs

Research details new strategy for overcoming treatment resistance by zeroing in on dendritic cells

Advancements in research on cancer signal transduction and treatment

Powerful drug used in chemotherapy could alleviate hallucinations in Parkinson's patients

Study finds new transposon-derived genes related to autism

Age can affect response to adjuvant treatment among patients with resected melanoma

DNA vaccine-induced antibodies neutralize SARS-CoV-2

UCLA researchers discover compound that stimulates muscle cells in mice

New vaccine targeting toxic Aβ may offer clinical benefit in treating Alzheimer's disease

Anti-inflammatory therapy helps slow progression of multiple sclerosis in a preclinical model

Study findings may help identify new targets to inhibit spread of melanoma

Adult stem cell-based lung organoid models emulate host immune response in fatal COVID-19

Promising interim results for Sinopharm's inactivated whole-virion SARS-CoV-2 vaccine

Cleveland Clinic joins new Center for Integrated Multi-Modal and Multi-Scale Nucleome Research

Patients with congenital heart defects have lower risk of severe COVID-19 symptoms

Antispastic drug candidate could offer new hope for millions of patients suffering from spasticity

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