Antibody News and Research

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An antibody is a blood protein that is produced in response to and counteracts an antigen. Antibodies are produced in response to disease and help the body fight against the particular disease. In this way, antibodies help the body develop an immunity to disease.

How next-gen sequencing is changing antibody drug discovery

New study outlines how next-generation sequencing (NGS) and machine-learning methods can revolutionize antibody discovery, particularly against SARS-CoV-2. The research demonstrates that NGS provides greater epitopic and paratopic diversity, enabling more effective identification and prioritization of therapeutic antibodies.

31 Oct 2023

Trastuzumab deruxtecan offers added benefit for patients with HER2-low breast cancer

The antibody-drug conjugate trastuzumab deruxtecan is approved for various therapeutic indications. Since March 2023, it can also be used as monotherapy for the treatment of adults with unresectable or metastatic HER2-low breast cancer who have received prior chemotherapy at this disease stage or developed disease recurrence early after adjuvant chemotherapy.

31 Oct 2023

New classification criteria for antiphospholipid syndrome

APS is a systemic autoimmune disease associated with persistent antiphospholipid antibodies (aPL). It can cause thrombosis and pregnancy complications as well as non-thrombotic manifestations such as cardiac valve disease.

30 Oct 2023

Study unveils new approach to more precise, long-lasting, and less toxic cancer treatment

For too long, cancer treatment has been a double-edged sword – the very treatments designed to kill cancer cells often wrought havoc on healthy ones too.

30 Oct 2023

New antibody may offer effective drug treatment for breast cancer

An enzyme that may help some breast cancers spread can be stopped with an antibody created in the lab of Cold Spring Harbor Laboratory Professor Nicholas Tonks.

30 Oct 2023

New omicron sublineages surge, but Pfizer-BioNTech bivalent booster retains effectiveness

The efficacy of the bivalent Pfizer-BioNTech COVID-19 messenger ribonucleic acid (mRNA) vaccine BNT162b2 BA.4/5.

30 Oct 2023

Diabetic patients with COVID-19: low antibody levels linked to worse outcomes

The role of anti-SARS-CoV-2 antibody levels on COVID-19 outcomes in patients with T2D.

30 Oct 2023

Redefining the battle against Alzheimer's with tau-focused treatments

Researchers explore the potential of tau-targeting therapies in treating Alzheimer's disease, focusing on immunotherapies and strategies to improve their efficacy. The study dives into the complex biology of tau proteins, their modifications, and how they can be targeted to halt the progression of Alzheimer's.

29 Oct 2023

MHRA grants conditional marketing authorization for AbbVie's Tepkinly to treat aggressive blood cancer

AbbVie today announced that the UK Medicines and Healthcare products Regulatory Agency has granted conditional Marketing Authorisation for Tepkinly® (epcoritamab) as a monotherapy for the treatment of adults with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL), after two or more systemic therapies.

28 Oct 2023

New treatment combination shows promise for metastatic colorectal cancer patients with rare genetic mutation

An international Phase 3 clinical trial found that metastatic colorectal cancer patients with a rare genetic tumor mutation called KRAS G12C experienced superior progression-free survival rates compared to standard of care when offered a combination treatment of KRAS inhibitor sotorasib and monoclonal antibody panitumumab.

27 Oct 2023

A new era of vaccines leaves old questions about prices unanswered

The world is entering a new era of vaccines. Following the success of covid-19 mRNA shots, scientists have a far greater capacity to tailor shots to a virus's structure, putting a host of new vaccines on the horizon.

27 Oct 2023

Microbubble-based biomarker could improve NIR-PIT treatment for cancer

Researchers at Nagoya University in Japan and their collaborators have used a biomarker based on microbubbles to evaluate the success of near-infrared photoimmunotherapy (NIR-PIT) treatment.

26 Oct 2023

Study shows phages can promote mammalian cellular growth and survival

Bacteriophages, also called phages, are viruses that infect and kill bacteria, their natural hosts. But from a macromolecular viewpoint, phages can be viewed as nutritionally enriched packets of nucleotides wrapped in an amino acid shell.

26 Oct 2023

Dato-DXd improves progression-free survival in patients with metastatic non-squamous NSCLC

Treatment with datopotamab deruxtecan (Dato-DXd), a novel Trop-2 directed antibody-drug conjugate, was found to significantly improve progression-free survival in patients with metastatic non-small cell lung cancer, an improvement that was primarily driven by patients with non-squamous tumors.

26 Oct 2023

Study helps identify children at the highest risk of severe RSV infection

A new study helps to identify children who are at the highest risk of a severe respiratory syncytial virus (RSV) infection and who would thus benefit most from new RSV prevention measures.

26 Oct 2023

New Sartorius Digital Handbook brings the power of High-Throughput Screening (HTS) by cytometry to every scientist

Sartorius, an industry-leading innovator of advanced instruments for cell analysis has released its first Advanced Flow Cytometry Handbook as a comprehensive digital guide to assays and workflows on the iQue® Advanced High Throughput Flow Cytometry Platform.

From Sartorius 26 Oct 2023

Kids not the culprits: Low COVID-19 spread in U.S. child-care centers challenges closure norms

The study found that both children and care providers in U.S. child-care centers showed low rates of COVID-19 transmission, challenging the notion that these settings are high-risk environments for the virus. The results could have implications for revising guidelines on school and child-care center closures.

25 Oct 2023

How strep bacteria outsmart your immune system and why it matters for treatment

Researchers discover that Group A streptococcal infections alter immunoglobulin G (IgG) homeostasis to evade the immune system, affecting the transition from local to systemic infections. The study also raises concerns about the effectiveness of antibody-based therapies, as the bacteria's virulence factors can degrade therapeutic antibodies.

25 Oct 2023

NF-κB activation during COVID-19 and its impact on patients with hypertension

Researchers review the role of NF-κB activation in the replication of SARS-CoV-2 and the impact of COVID-19 medications on NF-κB activation.

25 Oct 2023

Study shows benefit of convalescent plasma in Covid-19 patients requiring artificial ventilation

In a study published in The New England Journal of Medicine, clinicians and researchers from the CHU of Liège and the University of Liège show that the administration of plasma taken from convalescent donors after infection with Sars-CoV-2 to patients suffering from acute respiratory distress syndrome requiring artificial mechanical ventilation significantly reduced mortality (10%).

25 Oct 2023

Antibody News and Research

Further Reading

How next-gen sequencing is changing antibody drug discovery

Trastuzumab deruxtecan offers added benefit for patients with HER2-low breast cancer

New classification criteria for antiphospholipid syndrome

Study unveils new approach to more precise, long-lasting, and less toxic cancer treatment

New antibody may offer effective drug treatment for breast cancer

New omicron sublineages surge, but Pfizer-BioNTech bivalent booster retains effectiveness

Diabetic patients with COVID-19: low antibody levels linked to worse outcomes

Redefining the battle against Alzheimer's with tau-focused treatments

MHRA grants conditional marketing authorization for AbbVie's Tepkinly to treat aggressive blood cancer

New treatment combination shows promise for metastatic colorectal cancer patients with rare genetic mutation

A new era of vaccines leaves old questions about prices unanswered

Microbubble-based biomarker could improve NIR-PIT treatment for cancer

Study shows phages can promote mammalian cellular growth and survival

Dato-DXd improves progression-free survival in patients with metastatic non-squamous NSCLC

Study helps identify children at the highest risk of severe RSV infection

New Sartorius Digital Handbook brings the power of High-Throughput Screening (HTS) by cytometry to every scientist

Kids not the culprits: Low COVID-19 spread in U.S. child-care centers challenges closure norms

How strep bacteria outsmart your immune system and why it matters for treatment

NF-κB activation during COVID-19 and its impact on patients with hypertension

Study shows benefit of convalescent plasma in Covid-19 patients requiring artificial ventilation

Monoclonal Antibody Manufacturing Trends eBook eBook

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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