Clinical Trial News and Research

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Green tea compound may offer new treatment option for uterine fibroids

In a pre-clinical, proof-of-concept study from Johns Hopkins Medicine, researchers found that epigallocatechin gallate (EGCG), a green tea compound with powerful antioxidant properties, could be promising for both treating and preventing uterine fibroids.

13 Jul 2023

New precision medicine trial shows promise for treating rare brain tumors

Papillary craniopharyngiomas (PCPs) are a rare type of brain tumor that cause substantial morbidity for patients.

13 Jul 2023

Ancient remedy oxymel shows potential for modern wound care

The mixture of honey and vinegar, also known as oxymel, has been used as a medical treatment throughout history and now scientists have established that this combination could have modern applications in the treatment of wounds.

12 Jul 2023

Study shows potential for treating ALS with two existing drugs

New research suggests that targeting autoimmune inflammation associated with amyotrophic lateral sclerosis (ALS) using two drugs, one of them already approved for multiple sclerosis, could be a promising approach for treatment.

12 Jul 2023

CBT can be an effective first-line treatment for insomnia among individuals with alcohol use disorder

A study led by a University of Missouri School of Medicine researcher has established that cognitive behavioral therapy (CBT) is an effective first-line treatment for insomnia among individuals with alcohol use disorder, regardless of abstinence from alcohol.

12 Jul 2023

Lecanemab: First disease-modifying therapy for Alzheimer's disease approved by FDA

On July 6, 2023, the U.S. Food and Drug Administration granted full approval to lecanemab, marketed as Leqembi, for the treatment of Alzheimer's disease.

12 Jul 2023

Chemotherapy-induced changes to gut bacteria linked to unhealthy weight gain in breast cancer patients

Researchers have found a link between chemotherapy-induced changes to gut bacteria and the unhealthy weight gain seen in breast cancer patients, pointing the way to potentially help survivors avoid obesity-related illness later in their lives.

11 Jul 2023

Cytisinicline could offer adult cigarette smokers a potential new treatment option

The first large-scale U.S. clinical trial of cytisinicline, led by a Massachusetts General Hospital (MGH) investigator, found the smoking cessation medication to be effective and well tolerated in adults who wished to break their nicotine dependence.

11 Jul 2023

New clinical trial seeks a regenerative pharmaceutical solution for meniscal tears

With support from Amplicore, a University of Cincinnati spinoff biopharmaceutical company, researchers at UC have begun a Department of Defense-funded clinical trial that seeks a regenerative pharmaceutical solution for meniscal tears.

10 Jul 2023

High tumor monocyte content linked to better outcomes for esophageal cancer patients

A Ludwig Cancer Research study has discovered that the presence of relatively high numbers of immune cells known as monocytes in tumors is linked to better outcomes in esophageal cancer patients treated with a combination of chemotherapy and immunotherapy, or immunochemotherapy.

10 Jul 2023

Biomarkers in the brain could redefine mental health conditions

The study of biomarkers in the brain - powered by cutting-edge machine learning techniques - could redefine the way mental health conditions are categorized and diagnosed and lead to more effective, personalized treatments.

10 Jul 2023

Two anti-inflammatory drugs reduce deaths in severe COVID-19 patients

Two anti-inflammatory drugs, abatacept and infliximab, reduced deaths among patients hospitalized with severe COVID-19, according to a national study led by Washington University School of Medicine in St. Louis. William G. Powderly, MD, (right) who led the large clinical trial, discusses patient conditions with Maanasi Samant, MD, in the intensive care unit at Barnes-Jewish Hospital, one of the major trial sites, during the COVID-19 pandemic.

10 Jul 2023

Do system-level DOAC therapy management services affect anticoagulation outcomes for AF patients compared to usual care?

Researchers compared outcomes related to three direct oral anticoagulant (DOAC) care models.

10 Jul 2023

Depression after TBI may not be the same as depression related to other causes, study suggests

A new study led by Shan Siddiqi, MD, from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, suggests that depression after traumatic brain injury (TBI) could be a clinically distinct disorder rather than traditional major depressive disorder, with implications for patient treatment.

10 Jul 2023

Pulse oximetry: A 50-year-old device gets an upgrade

A portable device used to detect blood oxygen levels revolutionized the medical field 50 years ago and is now receiving essential updates

7 Jul 2023

Fecal transplants safe and effective in treating advanced melanoma, clinical trial shows

In a world-first clinical trial published in the journal Nature Medicine, a multi-center study from Lawson Health Research Institute, the Centre hospitalier de l'Université de Montréal and the Jewish General Hospital (JGH) has found fecal microbiota transplants (FMT) from healthy donors are safe and show promise in improving response to immunotherapy in patients with advanced melanoma.

7 Jul 2023

Immunotherapy significantly improves overall survival for advanced NSCLC patients

A global study, led by UCL and UCLH and sponsored by Roche, has shown that the cancer immunotherapy atezolizumab significantly improved the overall survival of advanced stage non-small cell lung cancer patients who were not able to be treated with platinum-containing chemotherapy, when compared to single-agent chemotherapy.

6 Jul 2023

Clinical Trial News and Research

Green tea compound may offer new treatment option for uterine fibroids

New precision medicine trial shows promise for treating rare brain tumors

Ancient remedy oxymel shows potential for modern wound care

Study shows potential for treating ALS with two existing drugs

CBT can be an effective first-line treatment for insomnia among individuals with alcohol use disorder

Lecanemab: First disease-modifying therapy for Alzheimer's disease approved by FDA

Chemotherapy-induced changes to gut bacteria linked to unhealthy weight gain in breast cancer patients

Cytisinicline could offer adult cigarette smokers a potential new treatment option

New clinical trial seeks a regenerative pharmaceutical solution for meniscal tears

High tumor monocyte content linked to better outcomes for esophageal cancer patients

Biomarkers in the brain could redefine mental health conditions

Two anti-inflammatory drugs reduce deaths in severe COVID-19 patients

Do system-level DOAC therapy management services affect anticoagulation outcomes for AF patients compared to usual care?

Depression after TBI may not be the same as depression related to other causes, study suggests

Pulse oximetry: A 50-year-old device gets an upgrade

Fecal transplants safe and effective in treating advanced melanoma, clinical trial shows

Immunotherapy significantly improves overall survival for advanced NSCLC patients

Kidney transplant recipients may benefit from new fluid therapy

Using digital health technologies for assessment of people with Parkinson's

Aneuploidy could function as a therapeutic target for cancer

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