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Mast cells found to capture and employ neutrophils during allergic reactions

Known for their role in allergic reactions, mast cells have long been recognised as key players in our immune system.

2 Aug 2024

Novel electrical impedance technique enhances drug testing for cardiac safety

When developing new drugs, understanding their effects on ion channels in the body, such as the human ether-a-go-go-related gene (hERG) ion channel found in neurons and heart muscle cells, is critical.

1 Aug 2024

ACE technology enhances single-cell protein detection with advanced signal amplification

Since the 1950s, researchers have used a famous method invented by Wallace Coulter known as "flow cytometry" to characterize different types of immune cells in research studies and in blood samples from human individuals.

30 Jul 2024

New brain atlas reveals hidden cell vulnerabilities in Alzheimer's

Researchers created a detailed transcriptomic atlas of six brain regions, revealing cell-type-specific and region-specific vulnerabilities in Alzheimer's disease and highlighting astrocyte genes linked to cognitive resilience.

25 Jul 2024

Novel antisense therapy targets α-synuclein pathologies in neurodegenerative diseases

TMDU researchers demonstrate proof of concept of antisense nucleic acid therapy to prevent the spread of α-synuclein pathologies in synucleinopathies.

25 Jul 2024

Creating the first genetically susceptible mice for late-onset Alzheimer's

Mice don't get Alzheimer's - and while that's good news for mice, it's a big problem for biomedical researchers seeking to understand the disease and test new treatments.

24 Jul 2024

Kaempferol's promise in fighting triple-negative breast cancer

Review highlights kaempferol's potential in treating triple-negative breast cancer through various anticancer mechanisms and improving chemotherapeutic efficacy.

24 Jul 2024

Dietary interventions improve mitochondrial function and reduce inflammation in obesity

Study demonstrates that dietary interventions such as calorie restriction, intermittent fasting, and ketogenic diet improve mitochondrial function in monocytes and reduce inflammation in obesity by modulating gut microbiota.

23 Jul 2024

Exploring non-coding RNAs as regulators of notch signaling in breast cancer

Breast cancer (BC) remains one of the most challenging cancers to treat, primarily due to its heterogeneity and propensity for metastasis.

23 Jul 2024

Revolutionary ATP imaging technique sheds light on kidney cell energy production

The prevalence of kidney disease has been increasing in Japan, with it now affecting one in eight adults, but developing effective treatment remains a challenge.

23 Jul 2024

Combination therapy incorporating three existing drugs shows potential for treating retinal degenerations

Drug repurposing shows promise in the treatment of retinal degenerations, according to a new study by an international team of researchers, published in Nature Communications.

22 Jul 2024

Understanding astrocyte-neuron interplay in learning deficits

In the brain, synaptic plasticity - the ability to change neuronal connections over time - is fundamental to learning and memory.

18 Jul 2024

Study finds dairy cows vulnerable to flu strains from birds, humans, and pigs

Researchers compared the distribution of sialic acid receptors in the respiratory tract and mammary glands of dairy cattle naturally infected with the highly pathogenic avian influenza A(H5N1) virus.

18 Jul 2024

Tinnitus linked to obesity and body composition in men, study finds

Study finds a significant link between tinnitus and body composition, particularly highlighting higher obesity-related inflammation in men as a potential factor.

17 Jul 2024

Twincretin drug Tirzepatide shows unmatched efficacy in weight loss and diabetes management

Tirzepatide, a novel twincretin drug, significantly improves weight loss and glycemic control in obese and type 2 diabetes patients, outperforming traditional treatments in clinical trials.

15 Jul 2024

Leveraging antibodies as a drug delivery mechanism may prove useful in the treatment of cancers

The primary goal in cancer drug research is not merely to discover compounds that can destroy cancer cells, but to develop methods that specifically target and deliver these agents to cancer cells, sparing healthy ones.

11 Jul 2024

Pentamidine: A promising prophylactic against chlamydial infections

Despite the significant increase in sexually transmitted diseases in recent years, there is currently no vaccine available against common bacterial pathogens such as chlamydia.

9 Jul 2024

How does SARS-CoV-2 cause lymphopenia when T cells barely express ACE-2 receptors?

Researchers reveal both direct and indirect mechanisms of SARS-CoV-2-induced lymphopenia, highlighting the role of CD147 and alternative viral entry routes into T cells.

8 Jul 2024

Heparan-sulfate proteoglycans found to influence Alzheimer's cell pathology

The impact of heparan-sulfate-modified proteoglycans (HSPGs) on Alzheimer's disease-associated pathways.

5 Jul 2024

Protein nanocages: A promising frontier in mRNA therapeutics

In recent years, messenger RNA (mRNA) has emerged as a promising avenue for accurate and potent therapeutic interventions. Unlike DNA drugs, mRNA can express genetic information without the risk of integrating into the host genome.

3 Jul 2024

Intracellular News and Research

Mast cells found to capture and employ neutrophils during allergic reactions

Novel electrical impedance technique enhances drug testing for cardiac safety

ACE technology enhances single-cell protein detection with advanced signal amplification

New brain atlas reveals hidden cell vulnerabilities in Alzheimer's

Novel antisense therapy targets α-synuclein pathologies in neurodegenerative diseases

Creating the first genetically susceptible mice for late-onset Alzheimer's

Kaempferol's promise in fighting triple-negative breast cancer

Dietary interventions improve mitochondrial function and reduce inflammation in obesity

Exploring non-coding RNAs as regulators of notch signaling in breast cancer

Revolutionary ATP imaging technique sheds light on kidney cell energy production

Combination therapy incorporating three existing drugs shows potential for treating retinal degenerations

Understanding astrocyte-neuron interplay in learning deficits

Study finds dairy cows vulnerable to flu strains from birds, humans, and pigs

Tinnitus linked to obesity and body composition in men, study finds

Twincretin drug Tirzepatide shows unmatched efficacy in weight loss and diabetes management

Leveraging antibodies as a drug delivery mechanism may prove useful in the treatment of cancers

Pentamidine: A promising prophylactic against chlamydial infections

How does SARS-CoV-2 cause lymphopenia when T cells barely express ACE-2 receptors?

Heparan-sulfate proteoglycans found to influence Alzheimer's cell pathology

Protein nanocages: A promising frontier in mRNA therapeutics

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