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Orphan noncoding RNAs define cancer identity and enable blood-based monitoring

We knew we had something interesting with T3p, a single small RNA found in breast cancer but absent from normal tissue.

24 Jan 2026

Dual-responsive nanodelivery system enhances immunotherapy efficacy in metastatic bladder cancer

Metastatic urothelial carcinoma has a poor prognosis: ~50% of muscle-invasive bladder cancer progresses to metastasis, and the 5-year survival for advanced/metastatic disease is <10%.

24 Jan 2026

New copper-based drug shows promise against antibiotic-resistant MRSA

A research team at the University of Arizona College of Medicine – Tucson is developing a drug that works in combination with copper to kill bacteria, including those that cause MRSA, a type of staph infection that is resistant to usual treatments.

22 Jan 2026

Targeted uterine mRNA treatment boosts fertility outcomes in mice

Researchers from the Wilmer Eye Institute, Johns Hopkins Medicine Center for Nanomedicine - which designs nanotechnology-based platforms for clinical translation across specialties - developed a strategy for delivering therapeutic messenger RNA (mRNA) to the inner lining of the uterus (endometrium) in mice via modified lipid nanoparticles (LNPs), which are small capsules made of fatty molecules.

22 Jan 2026

FIU's personalized cancer treatment shows promise

Researchers at FIU are advancing a personalized approach to cancer treatment that is showing increasingly promising results for patients with hard-to-treat disease, supported by new philanthropic investment that is helping expand the science behind the work.

22 Jan 2026

Age-related changes in the gut microbiota impair intestinal stem cell function

A new study led by Hartmut Geiger at the University of Ulm, Germany, and Yi Zheng and Kodandaramireddy Nalapareddy, Cincinnati Children's Hospital Medical Center (CCHMC), USA reveals that age-related changes in the gut microbiota directly impair intestinal stem cell (ISC) function and that restoring a youthful microbial environment can reverse this decline.

22 Jan 2026

New ISSCR guidance charts path for pluripotent stem cell therapies

The International Society for Stem Cell Research (ISSCR) today announced the upcoming release of "Charting the Translational Pathway: ISSCR Best Practices for the Development of Pluripotent Stem Cell (PSC)-Derived Therapies," a new paper highlighting some of the most critical aspects of the ISSCR's breakthrough interactive resource designed to transform how PSC-derived therapies are developed, evaluated, and advanced toward clinical and commercial success.

22 Jan 2026

Myosteatosis: An emerging predictor of outcomes in chronic liver disease

Myosteatosis, the pathological infiltration of fat into skeletal muscle, is increasingly recognized as a key predictor of poor clinical outcomes across a spectrum of liver diseases.

22 Jan 2026

See through the skin: New technology spots early heart disease warning signs

Researchers from Helmholtz Munich and the Technical University of Munich (TUM) have developed "fast-RSOM", a new imaging technology that can capture detailed images of the smallest blood vessels directly through the skin – without the need for invasive procedures.

22 Jan 2026

Unlocking microbial secrets for health on Earth and beyond

Microorganisms live in biofilms - the equivalent of microbial "cities"- everywhere on Earth. These city-like structures protect and house microbial communities and play essential roles in enabling human and plant health on our planet.

22 Jan 2026

Study shows DHPS enzyme controls macrophage maturation across multiple organs

A new study led by researchers at the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Bloomberg School of Public Health found that an enzyme involved in protein translation is essential for circulating immune cells, called monocytes, to mature into tissue-resident macrophages, a specialized population of immune cells that maintain organ health by clearing dead cells and debris.

21 Jan 2026

Researchers discover a biochemical route that plays role in Parkinson's disease

About 1 million Americans suffer from Parkinson's disease, with around 90,000 new cases diagnosed each year, according to the Parkinson's Foundation.

20 Jan 2026

Monolithic photocurable hyaluronic acid patch achieves strong wet adhesion for durotomy repair

Durotomy is a common neurosurgical complication involving a tear in the dura mater, the protective membrane surrounding the brain and spinal cord.

16 Jan 2026

Thermogenic beige fat protects blood vessels from hypertension

Obesity causes hypertension. Hypertension causes cardiovascular disease. And cardiovascular disease is the leading cause of death worldwide.

15 Jan 2026

Disease-responsive nanoparticles enable ghrelin mRNA therapy in osteoarthritis

Nitin Joshi, PhD, and Jingjing Gao, PhD, of the Department of Anesthesiology at Mass General Brigham, are the co-senior authors of a paper published in Nature Nanotechnology, "A disease-severity-responsive nanoparticle enables potent ghrelin mRNA therapy in osteoarthritis." Mahima Dewani, PhD, is the lead author of this study.

14 Jan 2026

New metabolomic signature predicts type 2 diabetes risk beyond traditional factors

Diabetes, a metabolic disease, is on the rise worldwide, and over 90 percent of cases are type 2 diabetes, where the body does not effectively respond to insulin.

14 Jan 2026

ALS breakthrough: Restoring protein production in motor neuron axons

Researchers at VIB and KU Leuven have identified a molecular process that allows motor neurons to maintain protein production, a process that fails in amyotrophic lateral sclerosis (ALS).

12 Jan 2026

Aptamer-based biosensors could transform viral detection

Rapid and reliable virus detection is one of the most critical tools for controlling outbreaks, from seasonal influenza to global pandemics like COVID-19.

9 Jan 2026

CRISPR Cas12a3: A precise tool to halt viral protein production

Across all domains of life, immune defenses foil invading viruses by making it impossible for the viruses to replicate. Most known CRISPR systems target invading pathogens' DNA and chop it up to disable and modify genes, heading off infections at the (cellular) pass.

7 Jan 2026

Pitavastatin shows pomise in overcoming chemotherapy resistance in triple-negative breast cancer

Triple-negative breast cancer (TNBC) is among the most aggressive types of breast cancer, lacking estrogen, progesterone, and HER2 receptors and thus relying primarily on cytotoxic chemotherapy.

7 Jan 2026