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New class of antivirals shows promise against multiple viruses

The arrival of Paxlovid in December 2021 marked another turning point in the COVID-19 pandemic - an effective antiviral that has since successfully treated millions.

11 Dec 2024

Wiley expands its KnowItAll solutions with new tools for LC-MS analysis, enterprise data management, and additional spectral advances

The latest KnowItAll software accelerates spectral analysis, featuring automated LC-MS tools and extensive spectral libraries to optimize research workflows.

From John Wiley and Sons - Scientific Publishers 11 Dec 2024

High-dose chemotherapy followed by autologous stem cell transplant ineffective for patients with mantle cell lymphoma

Late-breaking research reveals there is no benefit from high-dose chemotherapy followed by autologous stem cell transplant (ASCT) for patients with mantle cell lymphoma (MCL) in remission following their initial treatment.

11 Dec 2024

Mayo Clinic researchers advocate for comprehensive TPMT genotyping across ancestries

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of African or African American descent. A novel study in The Journal of Molecular Diagnostics, published by Elsevier, details the researchers' goal to provide pharmacogenomic testing that can be used clinically to predict drug response that is beneficial to all patients, regardless of their ancestral background.

11 Dec 2024

Elevated PGE2 levels drive age-related skin changes and cancer risk

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 18, 2024, entitled, "Prostaglandin E2 regulates senescence and post-senescence neoplastic escape in primary human keratinocytes."

11 Dec 2024

New advisory offers evidence-based strategies to prevent postoperative delirium in older adults

Delirium and cognitive decline are common complications of anesthesia and surgery in older adults.

10 Dec 2024

Study links Western diet to chronic inflammation and colorectal cancer growth

Colorectal cancer, the second leading cause of cancer-related deaths in the United States, may be fueled by the food on our plates.

10 Dec 2024

Structural and functional brain changes found in individuals with opioid use disorder

Researchers at the Yale School of Medicine found structural and functional alterations in specific brain regions of individuals with opioid use disorder.

10 Dec 2024

Study unveils how Toxoplasma gondii parasites escape drug treatment

A study by Indiana University School of Medicine researchers sheds new light on how Toxoplasma gondii parasites make the proteins they need to enter a dormant stage that allows them to escape drug treatment.

10 Dec 2024

Financial hardship still prevents many asthma patients from taking medications

Despite a fall in the number of people with asthma over the past decade who say that cost has stopped them taking their meds as prescribed, financial hardship still remains a deterrent for 1 in 6 with the condition, suggests research published online in the respiratory medicine journal Thorax.

10 Dec 2024

New triplet therapies show promise for relapsed and newly diagnosed leukemias

Three clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated significant positive results from novel triplet therapies in the treatment of relapsed or refractory and newly diagnosed leukemias.

9 Dec 2024

Scientists uncover genetic code driving tumor formation and spread

A group of scientists at VCU Massey Comprehensive Cancer Center has revealed a new genetic code that acts like a cancer ringleader, recruiting and deploying a gang of tumor cells to incite a biological turf war by invading healthy organs and overpowering the normal cells.

9 Dec 2024

New advances offer hope for patients with systemic mastocytosis

Dana-Farber Cancer Institute researchers are breaking new ground in the fight against systemic mastocytosis, a rare and heterogeneous condition that is often challenging for clinicians to accurately diagnose and treat.

9 Dec 2024

Researchers identify key mechanisms behind heart disease in type 2 diabetes

People with type 2 diabetes have a higher risk of developing cardiovascular disease and dying prematurely due to atherosclerosis.

9 Dec 2024

Potential new treatment for motor neurone disease shows promising results

A potential new treatment for motor neurone disease (MND) developed by a company spun-out of The University of Queensland has produced successful results in a human clinical trial.

9 Dec 2024

Study identifies potential risk factor for aortic aneurysms in Loeys-Dietz syndrome

Studying the cells of people and genetically engineered mice, Johns Hopkins Medicine scientists say they have uncovered a potential reason why patients with Loeys-Dietz syndrome, an inherited connective tissue disorder, are especially prone to developing aneurysms at the root of the aorta, the major artery that carries blood away from the heart and to the rest of the body.

9 Dec 2024