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SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

In a new study, researchers used a cell-cell fusion assay to extract potentially cleaved spike protein products from syncytia in order to explore the functional and biochemical characteristics of spike (S) protein when it engages its receptor ACE2 in living cells.

10 Jan 2022

NYBC discovers novel small-molecule pancoronavirus fusion inhibitors

New York Blood Center has published a study that reports the discovery of highly potent small molecules with the ability to inhibit COVID-19 in infected individuals.

9 Jan 2022

Slight pH adjustment may turn a metabolic inhibiting drug into promising COVID-19 treatment

Mechanical engineering and materials science professor David Needham has shown that a slight increase in solution pH might be all it takes to turn a metabolic inhibiting drug, traditionally used to treat gut parasites, into a promising prophylactic/preventative nasal spray and early treatment throat spray for COVID-19.

7 Jan 2022

Small molecule identified as a SARS-CoV-2 inhibitor

A new study published in iScience reports the results of a screening strategy to identify small molecules that target viral entry to block infection with this virus.

6 Jan 2022

Host kinase identified as an inhibition target for SARS-CoV-2

In this experiment, the chemical probe SGC-CK2-1 inhibited virus replication at nanomolar concentration, showing a highly selective effect on the kinase.

6 Jan 2022

New drug targeting LF and onchocerciasis begins its first in human trial in Liverpool

A new drug developed by an LSTM led partnership, which targets the neglected tropical diseases lymphatic filariasis and onchocerciasis has begun its first in human trial.

6 Jan 2022

Serological antibody response to SARS-CoV-2 infection at a population level

The scientists in this study used pooled convalescent serum to examine the serologic response in a population at risk of infection.

6 Jan 2022

Streamlined, efficient approaches to cell culture spectrometry and analysis

As demand for the high throughput production of high quality, highly specialized and reliable cell culture products continues to rise, laboratories and manufacturers need to move away from traditional manual analysis methods in favor of advanced real-time analysis using power spectroscopic methods.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 6 Jan 2022

PhoreMost and POLARISqb announce a multi-target collaboration to investigate next-generation cancer therapies

PhoreMost Limited and Polaris Quantum Biotech (POLARISqb) today announced a collaboration to study oncology targets currently considered undruggable.

From PhoreMost 6 Jan 2022

New compound could combat multidrug-resistant pathogens in healthcare settings

For years, public-health experts have been sounding the alarm about the next phase in humanity's co-existence with bacteria - a dark future where emerging strains have rendered once-powerful antibiotics useless.

5 Jan 2022

New approach could offer a more accurate way to evaluate donor kidney quality

A new way to evaluate the quality of kidneys before transplantation could one day help increase the number of usable donor kidneys.

5 Jan 2022

Study uncovers a harmful neutrophil behavior linked to cardiovascular disease

Scientists led by Dr. Andrés Hidalgo at the Centro Nacional de Investigadores Cardiovasculares have discovered that circulating neutrophils - a type of immune cell - acquire different behavior patterns during inflammatory processes.

5 Jan 2022

NRL researchers aim to advance understanding of how cells organize and communicate

U.S. Naval Research Laboratory researchers in the Chemistry Division apply their knowledge of biology in conjunction with materials to improve understanding of how cells and tissues organize and apply new methods to affect cell communication.

5 Jan 2022

Wistar announces initiation of Phase 2 clinical study of VK-2019 in patients with advanced head and neck cancer

The Wistar Institute announces the initiation of a Phase 2 clinical study of VK-2019 in patients with advanced Epstein-Barr Virus (EBV)-positive nasopharyngeal carcinoma (NPC) and lymphoma.

5 Jan 2022

Study finds pan-sarbecovirus nanobodies can enhance development of super-immunity

A new study found that applying pan-sarbecovirus nanobodies shows a strong affinity toward all sarbecovirus clades and neutralized SARS-CoV-2 receptor binding domains

4 Jan 2022

Researchers identify a biomarker in platelets that tracks the extent of depression

Researchers are one step closer to developing a blood test that provides a simple biochemical hallmark for depression and reveals the efficacy of drug therapy in individual patients.

3 Jan 2022

Humanized antibody shows strong neutralization ability against SARS-CoV-2 Delta variant

Researchers combine SARS-CoV-2 spike vaccination with single-cell B-cell receptor sequencing technology to discover neutralizing antibody candidates.

3 Jan 2022

Researchers investigate the effect of emerging SARS-CoV-2 mutations on ACE2 binding

Now in new research, scientists from the University of Leicester have been investigating how these mutations alter the affinities of RBDs to ACE2.

28 Dec 2021

Scientists identify a new Achilles' heel of influenza virus

Scientists at Scripps Research, University of Chicago and Icahn School of Medicine at Mount Sinai have identified a new Achilles' heel of influenza virus, making progress in the quest for a universal flu vaccine.

24 Dec 2021

Researchers unravel how our organs know when to stop growing

The smallest fish in the world, the Paedocypris, measures only 7 millimeters. This is nothing compared to the 9 meters of the whale shark.

23 Dec 2021

Molecule News and Research

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

NYBC discovers novel small-molecule pancoronavirus fusion inhibitors

Slight pH adjustment may turn a metabolic inhibiting drug into promising COVID-19 treatment

Small molecule identified as a SARS-CoV-2 inhibitor

Host kinase identified as an inhibition target for SARS-CoV-2

New drug targeting LF and onchocerciasis begins its first in human trial in Liverpool

Serological antibody response to SARS-CoV-2 infection at a population level

Streamlined, efficient approaches to cell culture spectrometry and analysis

PhoreMost and POLARISqb announce a multi-target collaboration to investigate next-generation cancer therapies

New compound could combat multidrug-resistant pathogens in healthcare settings

New approach could offer a more accurate way to evaluate donor kidney quality

Study uncovers a harmful neutrophil behavior linked to cardiovascular disease

NRL researchers aim to advance understanding of how cells organize and communicate

Wistar announces initiation of Phase 2 clinical study of VK-2019 in patients with advanced head and neck cancer

Study finds pan-sarbecovirus nanobodies can enhance development of super-immunity

Researchers identify a biomarker in platelets that tracks the extent of depression

Humanized antibody shows strong neutralization ability against SARS-CoV-2 Delta variant

Researchers investigate the effect of emerging SARS-CoV-2 mutations on ACE2 binding

Scientists identify a new Achilles' heel of influenza virus

Researchers unravel how our organs know when to stop growing

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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