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Targeting ST6Gal-I shows promise in reducing Alzheimer’s disease pathology

A recent study published in Engineering has provided novel insights into the involvement of α2,6-sialylation in Alzheimer's disease (AD), revealing that the ablation of α2,6-sialyltransferase-I (ST6Gal-I), an enzyme responsible for α2,6-sialylation, can downregulate BACE1 expression and suppress the production of amyloid-β42 (Aβ42) plaques, which are hallmarks of AD.

20 Jun 2025

Multiple brain profiles underlie the same symptoms in depression

A novel study aimed at disentangling the neurological underpinnings of depression shows that multiple brain profiles may manifest as the same clinical symptoms, providing evidence to support the presence of both one-to-one and many-to-one heterogeneity in depression.

20 Jun 2025

Transfer RNA-derived small RNAs transform the landscape of liquid biopsy

A new review highlights the transformative potential of transfer RNA-derived small RNAs (tsRNAs) in the field of liquid biopsy, emphasizing their role as promising biomarkers for a wide range of diseases, particularly cancers.

20 Jun 2025

Inflammation and immune dysregulation drive breast cancer in aging women

Age-related and postmenopausal breast cancer progression remains a significant challenge, with growing evidence pointing to the role of pro-inflammatory cytokines and CXC chemokines in tumor development and immune system modulation.

20 Jun 2025

Targeting IGF2BP1 offers a new approach to cancer therapy

The RNA-binding protein IGF2BP1 has emerged as a key regulator of cancer hallmarks, influencing tumor proliferation, metastasis, immune evasion, and resistance to cell death.

20 Jun 2025

Study finds no evidence to suggest mild COVID-19 may cause long-term kidney damage

A new study of over 13 million people in England has found no evidence to suggest mild COVID-19 infection may cause long-term kidney damage.

19 Jun 2025

Autoantibodies against vinculin linked to childhood kidney disease

Idiopathic nephrotic syndrome (INS) is a serious kidney disease in children with no clear cause. In a recent study, researchers have identified a novel autoantibody targeting vinculin—a protein crucial for kidney cell structure—as a significant factor in INS.

19 Jun 2025

New technology tracks solid tumor treatment response through blood samples

Altum Sequencing, a start-up supported by the C3N-IA Science Park at Universidad Carlos III de Madrid (UC3M) and specialized in oncology, has developed a tool to monitor treatment response in patients with solid tumors from a simple blood sample.

19 Jun 2025

NHCS and Mayo Clinic join forces to advance global cardiovascular care

The National Heart Centre Singapore (NHCS) and Mayo Clinic have collaborated under a Memorandum of Understanding (MOU) to accelerate cardiovascular innovation and research, and to foster knowledge for future cardiovascular care worldwide.

19 Jun 2025

Food insecurity, neighborhood disadvantage, and lack of social support affect stroke outcomes

Having poor access to food, living in a disadvantaged neighborhood and not having strong friend and family support may lead to worse outcomes after stroke, according to a study published June 18, 2025, in Neurology® Clinical Practice, an official journal of the American Academy of Neurology.

19 Jun 2025

Genes may determine how early life exposures shape the gut microbiome

Early nutritional and antibiotic exposures affect adult gut microbiota, with genetic background and parent-of-origin significantly influencing outcomes.

19 Jun 2025

Full tumor DNA sequencing becomes standard for children with cancer

Readouts of the full DNA of children with cancer at diagnosis have been implemented as the standard of care in a European first.

19 Jun 2025

New meta-analysis highlights effective non-drug therapies for knee osteoarthritis

Knee braces, water therapy and exercise are the most promising non-drug therapies for treating knee osteoarthritis, according to a new meta-analysis publishing June 18, 2025 in the open-access journal PLOS One by Yuan Luo of the First People's Hospital of Neijiang, China.

19 Jun 2025

Study identifies strategies for expanding low-barrier wound care services for people who use drugs

A new study published in the Harm Reduction Journal identifies critical factors and strategies for expanding low-barrier wound care services for people who use drugs (PWUD).

19 Jun 2025

Intermittent fasting shows similar weight loss benefits to traditional diets

Intermittent fasting diets appear to have similar benefits to traditional calorie-restricted diets for weight loss, suggests an analysis of trial evidence published by The BMJ today.

19 Jun 2025

Cognitive decline tied to gut microbes and nutritional access

A new study led in part by Mount Sinai researchers has found a compelling link between the composition of the gut microbiome and the risk of cognitive impairment (RCI) in adults, underscoring the complex role that both biology and social determinants-such as food insecurity-play in brain health.

18 Jun 2025

Living near microplastic polluted waters linked to higher risk of heart and metabolic diseases

Living in a U.S. coastal county bordered by ocean waters with very high concentrations of microplastics may increase the risk of heart and metabolic diseases, such as Type 2 diabetes, coronary artery disease and stroke.

18 Jun 2025

CAR T-cell therapy successfully treats rare autoimmune disease of the peripheral nervous system

Physicians from Bochum have used a cancer treatment method to treat severe autoimmune diseases.

18 Jun 2025

Interferon pathway genes linked to treatment success in juvenile arthritis

A set of genes that could be used to help doctors predict which children will respond well to treatment for juvenile idiopathic arthritis (JIA) have been identified by researchers at UCL and Great Ormond Street Hospital for Children (GOSH), who are part of the CLUSTER Consortium.

18 Jun 2025

OCCAM Immune and Cancer Research Institute join forces to advance immunotherapy

In a new collaboration that could transform how cancer is treated, OCCAM Immune-a Mount Sinai initiative focused on understanding the immune system's role in disease-is partnering with the Cancer Research Institute (CRI) to unlock the secrets of how the immune system responds to advanced therapies.

17 Jun 2025