Clinical Trial News and Research

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Understanding post-COVID interstitial lung disease: Causes, treatment options

After being hospitalized for three months with COVID-19 and double pneumonia in 2020, Houston police officer Hito Bazan awoke one morning to discover that he couldn't talk, eat, walk, or most importantly, breathe. Bazan was diagnosed with interstitial lung disease (ILD) known as pulmonary fibrosis (PF).

27 Apr 2023

Biomarker signature test can predict tumor response to bladder cancer immunotherapy

In a discovery that could improve the survival of bladder cancer patients, Northwestern Medicine scientists have developed a biomarker signature test to predict which tumors will respond to immunotherapy.

27 Apr 2023

Groundbreaking discovery could pave the way for safer and more effective blood thinners

Safer and more effective blood thinners could be on the way following a groundbreaking discovery by researchers at UBC and the University of Michigan, published today in Nature Communications.

26 Apr 2023

Checkpoint inhibitors may not be effective lymphoma treatment when CAR T fails

For 30% to 40% of lymphoma patients who receive CAR T therapy, the treatment is a godsend.

25 Apr 2023

Novel immunotherapy appears to be safe, well tolerated by children with relapsed brain tumors

The first in-human-study of a new immunotherapy that blocks a natural enzyme tumors commandeer for their protection was well tolerated by children with relapsed brain tumors and enabled many to have unexpected months of a more normal life, researchers say.

25 Apr 2023

Study shows how the brain benefits from consistently lower blood pressure

Intensive blood pressure treatment significantly reduces the risk of adverse cerebrovascular events such as stroke.

24 Apr 2023

Drug-metabolizing enzyme may be a major player in safety concerns related to the painkiller diclofenac

Safety concerns related to the widely used painkiller diclofenac may be tied to a little-studied drug-metabolizing enzyme whose expression can vary as much as 3,000 times from one individual to the next, according to new research.

24 Apr 2023

Mitophagy helps blood cancer cells to evade the killing effects of BH3 mimetic drug

Despite the promise of new medications that promote cancer cell death in people with acute myeloid leukemia, leukemic cells often adopt features that let them evade the drugs' effects within a year.

24 Apr 2023

Trial recommends replacing skull section following surgery to treat brain hemorrhage

A major international trial has concluded that, where possible, surgeons should replace the removed section of the skull following surgery to treat a form of brain hemorrhage.

24 Apr 2023

Pain, hope, and science collide as athletes turn to magic mushrooms

The boxer felt broken. Every day, he was waking up in pain. Some days, it was debilitating headaches. Other times, it was his back. Or his fists. His ribs. His nose. On top of that, he had mood swings. Depression. Anxiety.

24 Apr 2023

Study shows no significant cognitive benefit of adhering to Mediterranean diets regardless of calorie intake

Researchers investigated whether adhering to the Mediterranean diet with or without limiting calorie intake could improve cognition.

24 Apr 2023

Underrepresentation of women in research studies correlates with lack of female scientists

The underrepresentation of female research subjects has been documented from clinical trials down to sources for cell cultures.

21 Apr 2023

Weight loss surgery more effective for the treatment of non-alcoholic fatty liver disease

Metabolic (bariatric) surgery is more effective than medications and lifestyle interventions for the treatment of advanced non-alcoholic fatty liver disease.

21 Apr 2023

Collaborative trial set to prove the effectiveness of treating alcohol use disorder and PTSD

A collaborative multi-site randomized controlled trial at the University of Houston and the Medical University of South Carolina is set to prove the effectiveness of treating alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) together.

21 Apr 2023

NOVA system's food guidance: Valid concerns or oversimplification of health and diet?

Research evaluates the proposed mechanisms for the association between ultra-processed food (UPF) consumption and BMI. It concludes that there is limited evidence establishing causality and recommends against making recommendations about the role of UPF in diets before plausible mechanisms have been verified.

21 Apr 2023

New preservation temperature extends the lifespan of donor organ outside the body

Storing donor lungs for transplant at 10 degrees Celsius markedly increases the length of time the organ can live outside the body according to research led by a team of scientists at the Toronto Lung Transplant Program in the Ajmera Transplant Centre at the University Health Network.

20 Apr 2023

Study hints at the potential of sleep pills to slow or stop Alzheimer's disease progression

Sleep disturbances can be an early sign of Alzheimer's disease. Many people eventually diagnosed with Alzheimer's start experiencing difficulty falling and staying asleep years before cognitive problems such as memory loss and confusion emerge.

20 Apr 2023

Antibody combination strongly protects high-risk people with early COVID-19 symptoms, trial shows

A treatment combining two antibodies against the coronavirus SARS-CoV-2 strongly protected high-risk people with early COVID-19 symptoms from hospitalization and death in an international Phase 2/3 clinical trial conducted in the first half of 2021 and co-led by researchers at Weill Cornell Medicine and NewYork-Presbyterian.

20 Apr 2023

Houston-based cancer survivor donates $10 million to accelerate translational research and clinical trials

Vijay Goradia, a Houston-based businessman, philanthropist, and cancer survivor, has donated $10 million to The University of Texas MD Anderson Cancer Center to speed translational research and clinical trials.

20 Apr 2023

Delays in stoma reversal surgery do not affect post-operative clinical outcomes

Patients can be reassured that delays in stoma reversal surgery do not affect long-term outcomes according to research funded by Bowel Cancer UK and North West Cancer Research.

20 Apr 2023

Clinical Trial News and Research

Understanding post-COVID interstitial lung disease: Causes, treatment options

Biomarker signature test can predict tumor response to bladder cancer immunotherapy

Groundbreaking discovery could pave the way for safer and more effective blood thinners

Checkpoint inhibitors may not be effective lymphoma treatment when CAR T fails

Novel immunotherapy appears to be safe, well tolerated by children with relapsed brain tumors

Study shows how the brain benefits from consistently lower blood pressure

Drug-metabolizing enzyme may be a major player in safety concerns related to the painkiller diclofenac

Mitophagy helps blood cancer cells to evade the killing effects of BH3 mimetic drug

Trial recommends replacing skull section following surgery to treat brain hemorrhage

Pain, hope, and science collide as athletes turn to magic mushrooms

Study shows no significant cognitive benefit of adhering to Mediterranean diets regardless of calorie intake

Underrepresentation of women in research studies correlates with lack of female scientists

Weight loss surgery more effective for the treatment of non-alcoholic fatty liver disease

Collaborative trial set to prove the effectiveness of treating alcohol use disorder and PTSD

NOVA system's food guidance: Valid concerns or oversimplification of health and diet?

New preservation temperature extends the lifespan of donor organ outside the body

Study hints at the potential of sleep pills to slow or stop Alzheimer's disease progression

Antibody combination strongly protects high-risk people with early COVID-19 symptoms, trial shows

Houston-based cancer survivor donates $10 million to accelerate translational research and clinical trials

Delays in stoma reversal surgery do not affect post-operative clinical outcomes

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