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Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

An analysis of millions of SARS-CoV-2 genomes finds that recombination of the virus is uncommon, but when it occurs, it is most often in the spike protein region, the area which allows the virus to attach to and infect host cells.

11 Aug 2022

Transposable element controls the immune system to favor host survival during virus infection

Researchers from UNSW Sydney have discovered that a particular transposable element, or jumping gene, in the genome has a profound effect on the immune response to virus infection.

11 Aug 2022

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

DNA damage caused by factors such as ultraviolet radiation affect nearly three-quarters of all stem cell lines derived from human skin cells, say Cambridge researchers, who argue that whole genome sequencing is essential for confirming if cell lines are usable.

11 Aug 2022

Study defines how the circadian clock influences cell growth, metabolism and tumor progression

In a new University of California, Irvine-led study, researchers define how the circadian clock influences cell growth, metabolism and tumor progression.

11 Aug 2022

Scientists discover new target for treatment of premature aging disorders

A stretch of DNA that hops around the human genome plays a role in premature aging disorders, scientists at the Salk Institute and King Abdullah University of Science and Technology in Saudi Arabia have discovered.

10 Aug 2022

Refined analysis method provides new insights into the dominance transition of Omicron sublineages

Researchers at Karolinska Institutet in Sweden present the results of a refined clinical COVID-19 test, which has been used to track the spread of the Omicron variant in real time in the Swedish population.

10 Aug 2022

What is the correlation between monkeypox viral DNA and infectivity in clinical samples?

In a new study, researchers investigated the correlation between monkeypox virus (MPXV) infectivity and viral DNA content in clinical specimens.

10 Aug 2022

The features of the newly emerging SARS-CoV-2 Omicron BA.2.75 subvariant

Researchers evaluated all the features, especially the antigenic properties and transmission potential of SARS-CoV-2 Omicron sub-variant BA.2.75.

10 Aug 2022

A direct lineage-typing RT-PCR assay reveals insights into the transition from Omicron BA.1 to BA.2 dominance in Sweden

Researchers monitored the remarkably rapid Omicron BA.1 to BA.2 sublineage dominance transition in the Swedish population in early 2022 on a day-to-day basis using a customized lineage-typing RT-PCR assay.

10 Aug 2022

Researchers explore SARS-CoV-2 entry route and downstream cellular and viral processes

In a new study, researchers assessed the impact of the SARS-CoV-2 entry route on downstream cellular and viral processes.

10 Aug 2022

Coronavirus biology: viral RNA synthesis, origin, and vaccines

Researchers analyzed the characteristics of coronaviruses and novel CoV vaccine candidates.

10 Aug 2022

IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

CRISPR/Cas9 is a commonly used, very precise, gene editing technique whose development, by Jennifer A. Doudna and Emmanuelle Charpentier, was recognised with the 2020 Nobel Prize in Chemistry. Commonly known as "genetic scissors", CRISPR allows the introduction of the desired DNA sequence into (virtually) any spot of the genome, thus modifying or inactivating a gene. This technique is widely used in biomedical research and some CRISPR-based therapies are in clinical trials for the treatment of human blood disorders, some types of cancer and HIV, among other conditions.

10 Aug 2022

Pathogens in ancient DNA could explain how two civilizations collapsed

The current study has strongly indicated the presence of Y. pestis and S. enterica on the island of Crete that contributed to societal changes during 2,000 BCE.

9 Aug 2022

A genome-wide catalog of rare copy-number variant associations for 54 disease phenotypes

A recent study published in Cell illustrated a human genome map with dosage sensitivity across disorders.

9 Aug 2022

Evaluating vaccine effectiveness against Omicron BA.5 and BA.2 in Portugal

Researchers estimated the vaccine effectiveness (VE) of the primary and booster doses of COVID-19 vaccines against reinfection by Omicron BA.5 and BA.2 lineages and severe post-infection outcomes.

9 Aug 2022

Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Researchers evaluated the comparative pathogenicity of SARS-CoV-2 Omicron sub-variants BA.1, BA.2, and BA.5, in vitro and in vivo.

9 Aug 2022

Novel AI tools accurately predict the role of DNA’s regulatory elements

Newly developed artificial intelligence (AI) programs accurately predicted the role of DNA's regulatory elements and three-dimensional (3D) structure based solely on its raw sequence, according to two recent studies in Nature Genetics.

9 Aug 2022

Serbia's genome center monitors potential virus mutations to facilitate more effective COVID-19 control

In partnership with BGI Genomics from China, Serbia's first genome sequencing center, opened in December 2021, is monitoring potential virus mutations to facilitate more effective COVID-19 control and accelerating access to genomics to enhance health outcomes.

9 Aug 2022

Proof-of-concept model uses AI to combine multiple types of data to predict cancer outcomes

While it's long been understood that predicting outcomes in patients with cancer requires considering many factors, such as patient history, genes and disease pathology, clinicians struggle with integrating this information to make decisions about patient care.

8 Aug 2022

Research progress on the three-dimensional interaction between virus and host genome

A recent study reviewed the current progress on 3D interactions between host and viral genomes.

8 Aug 2022

Genome News and Research

Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

Transposable element controls the immune system to favor host survival during virus infection

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

Study defines how the circadian clock influences cell growth, metabolism and tumor progression

Scientists discover new target for treatment of premature aging disorders

Refined analysis method provides new insights into the dominance transition of Omicron sublineages

What is the correlation between monkeypox viral DNA and infectivity in clinical samples?

The features of the newly emerging SARS-CoV-2 Omicron BA.2.75 subvariant

A direct lineage-typing RT-PCR assay reveals insights into the transition from Omicron BA.1 to BA.2 dominance in Sweden

Researchers explore SARS-CoV-2 entry route and downstream cellular and viral processes

Coronavirus biology: viral RNA synthesis, origin, and vaccines

IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

Pathogens in ancient DNA could explain how two civilizations collapsed

A genome-wide catalog of rare copy-number variant associations for 54 disease phenotypes

Evaluating vaccine effectiveness against Omicron BA.5 and BA.2 in Portugal

Study suggests BA.5 evolved to induce enhanced inflammation when compared to prior Omicron subvariants

Novel AI tools accurately predict the role of DNA’s regulatory elements

Serbia's genome center monitors potential virus mutations to facilitate more effective COVID-19 control

Proof-of-concept model uses AI to combine multiple types of data to predict cancer outcomes

Research progress on the three-dimensional interaction between virus and host genome

Genetics & Genomics - Second Edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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