Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Pre-existing immunity to other coronaviruses may be poor

Brenda M. Westerhuis et al., in a recent medRxiv* preprint paper, investigate the antibody cross-reactivity - to explain the severe disease. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

13 Oct 2020

Cell-free DNA blood tests may help predict pregnancy complications

UCLA researchers say a blood test commonly used to detect fetal genetic abnormalities may help predict complications associated with pregnancy before symptoms develop.

13 Oct 2020

Neoadjuvant trial of combination immunotherapy has favorable outcomes in bladder cancer patients

Neoadjuvant, or pre-surgical, combination treatment with the immune checkpoint inhibitors tremelimumab (anti-CTLA-4) and durvalumab (anti-PD-1) was well-tolerated and showed early signs of activity in certain patients with localized bladder cancer who do not have standard treatment options available, according to a Phase I clinical trial conducted by The University of Texas MD Anderson Cancer Center.

13 Oct 2020

Enzyme SSH1 impairs the disposal of damaged tau and neurotoxic mitochondria

In a healthy brain, the multistep waste clearance process known as autophagy routinely removes and degrades damaged cell components - including malformed proteins like tau and toxic mitochondria.

12 Oct 2020

Even mild fatty liver disease associated with higher risk of all-cause mortality

Non-alcoholic fatty liver disease, NAFLD, affects nearly one in four adults in Europe and the U.S. Earlier research has demonstrated an increased risk of death in patients with NAFLD and advanced fibrosis or cirrhosis.

12 Oct 2020

Study highlights ongoing disparity in inflammatory breast cancer

Women with inflammatory breast cancer - a rare, highly aggressive form of the disease - are living about twice as long after diagnosis than their counterparts in the mid-to-late 1970s, according to a new University of Michigan Rogel Cancer Center study.

12 Oct 2020

A new therapeutic approach for Epstein-Barr virus-associated tumors

A research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) discovered that exosomes derived from Vδ2-T cells (Vδ2-T-Exos) can effectively control Epstein-Barr virus-associated tumours and induce T-cell anti-tumour immunity.

12 Oct 2020

CWRU and UH secure $4 million to establish research center focused on lung cancer in East Africa

Researchers with the Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have secured $4 million in funding from the National Institutes of Health (NIH)/National Cancer Institute to establish an HIV-associated Malignancy Research Center (HAMRC) focused on lung cancer in East Africa.

9 Oct 2020

Penn receives $4.5 million NIH grant to create a comprehensive resource for women’s health

Junhyong Kim, PhD, Chair and Patricia M. Williams Professor of Biology in the School of Arts and Sciences, and Kate O'Neill, MD MTR, Assistant Professor, Department of Obstetrics and Gynecology in the Perelman School of Medicine, have been awarded a Human BioMolecular Atlas Program (HuBMAP) grant supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development and the Common Fund of the National Institutes of Health.

9 Oct 2020

Study compares the effect of hydroxychloroquine versus favipiravir in SARS-CoV-2−infected hamsters

Virologists at the Rega Institute have shown that the anti-malaria drug hydroxychloroquine does not limit SARS-CoV-2 coronavirus replication in hamsters.

9 Oct 2020

Antibody cocktail may offer clinical benefit in both prevention and treatment of COVID-19

In June, two studies in Science reported an antibody cocktail against SARS-CoV-2 developed from studies in humanized mice and recovering patients. The two antibody cocktail was designed to bind the virus to reduce the risk of a drug-resistant form emerging.

9 Oct 2020

Research shows choroid plexus can act as a conduit for prenatal inflammation

Floating in fluid deep in the brain are small, little understood fronds of tissue. Two new studies reveal that these miniature organs are a hotbed of immune system activity.

9 Oct 2020

New digital dashboard enhances the efficiency of cancer case review

Multidisciplinary tumor boards are vital to cancer treatment plans, bringing together clinicians from different specialties to guide patient treatment and improve outcomes.

9 Oct 2020

University of Minnesota Medical School chosen as ‘Capacity Building Center’ for national network

The University of Minnesota Medical School's Department of Laboratory Medicine and Pathology has been selected to participate in a new national network dedicated to serological, or antibody, sciences as one of four Capacity Building Centers in the country.

9 Oct 2020

Mount Sinai to receive more than $7.3 million as part of NCI's new Serological Sciences Network

Researchers from the Icahn School of Medicine at Mount Sinai will receive more than $7.3 million from the National Cancer Institute as part of the NCI's new Serological Sciences Network (SeroNet), one of the largest coordinated national efforts to study immunology and SARS-CoV-2, the virus that causes COVID-19.

8 Oct 2020

Technological breakthrough may increase COVID-19 testing, reduce wait time and costs

The U.S. Food and Drug Administration has granted emergency use authorization for scientists at UCLA Health to begin using a new method of COVID-19 detection using sequencing technology called SwabSeq.

8 Oct 2020

Researchers discover a principle that explains metastasizing of prostate cancer

An international research team has discovered a principle that explains the metastasizing of prostate cancer.

8 Oct 2020

Simple sugar in human breast milk can promote myelin repair in multiple sclerosis patients

N-acetylglucosamine, a simple sugar found in human breast milk and sold as an over-the-counter dietary supplement in the United States, promotes myelin repair in mouse models and correlates with myelination levels in multiple sclerosis patients according to a new University of California, Irvine-led study.

8 Oct 2020

Cerenkov luminescence imaging can accurately assess surgical margins during radical prostatectomy

A new intraoperative imaging technique, Cerenkov luminescence imaging (CLI), can accurately assess surgical margins during radical prostatectomy, according to a first-in-human research published in the October issue of the Journal of Nuclear Medicine.

7 Oct 2020

Air pollution can cause neurological damage

Researchers looking at the brainstems of children and young adults exposed lifelong to air pollution in Mexico City have discovered disturbing evidence of harm.

7 Oct 2020

Pathology News and Research

Further Reading

Pre-existing immunity to other coronaviruses may be poor

Cell-free DNA blood tests may help predict pregnancy complications

Neoadjuvant trial of combination immunotherapy has favorable outcomes in bladder cancer patients

Enzyme SSH1 impairs the disposal of damaged tau and neurotoxic mitochondria

Even mild fatty liver disease associated with higher risk of all-cause mortality

Study highlights ongoing disparity in inflammatory breast cancer

A new therapeutic approach for Epstein-Barr virus-associated tumors

CWRU and UH secure $4 million to establish research center focused on lung cancer in East Africa

Penn receives $4.5 million NIH grant to create a comprehensive resource for women’s health

Study compares the effect of hydroxychloroquine versus favipiravir in SARS-CoV-2−infected hamsters

Antibody cocktail may offer clinical benefit in both prevention and treatment of COVID-19

Research shows choroid plexus can act as a conduit for prenatal inflammation

New digital dashboard enhances the efficiency of cancer case review

University of Minnesota Medical School chosen as ‘Capacity Building Center’ for national network

Mount Sinai to receive more than $7.3 million as part of NCI's new Serological Sciences Network

Technological breakthrough may increase COVID-19 testing, reduce wait time and costs

Researchers discover a principle that explains metastasizing of prostate cancer

Simple sugar in human breast milk can promote myelin repair in multiple sclerosis patients

Cerenkov luminescence imaging can accurately assess surgical margins during radical prostatectomy

Air pollution can cause neurological damage

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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