Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Canadian scientists trap gut microbe fuel to improve blood sugar and liver health

A team of Canadian scientists has discovered a surprising new way to improve blood sugar levels and reduce liver damage: by trapping a little-known fuel made by gut bacteria before they wreak havoc on the body.

30 Jul 2025

Exercise-based cardiac rehab benefits atrial fibrillation

Exercise-based cardiac rehabilitation lessens the severity, frequency, and recurrence of the most common form of irregular heart rhythm, atrial fibrillation, or AF for short, finds a pooled data analysis of the available research, published online in the British Journal of Sports Medicine.

30 Jul 2025

NR2F1 drives fibrotic cataract formation through activation of STAT3

Cataracts remain one of the most prevalent and debilitating eye conditions, often requiring surgical intervention to restore sight. Yet even after surgery, many patients develop anterior subcapsular cataracts (ASC), characterized by fibrotic tissue growth beneath the lens capsule.

29 Jul 2025

Siemens Healthineers sets new sustainability benchmark as first IVD manufacturer to earn My Green Lab ACT Ecolabel for analyzers, reagents

Siemens Healthineers has earned My Green Lab ACT Ecolabel Certification for more than 150 immunoassay and clinical chemistry reagents used globally by medical laboratories for in vitro diagnostic testing.

From Siemens Healthineers 29 Jul 2025

How a leaky gut could be putting your heart at risk

Researchers reviewed recent studies showing that gut dysbiosis contributes to heart failure by weakening the gut barrier, enabling harmful metabolites like TMAO to trigger inflammation and cardiac damage. The review highlights a bidirectional “gut-heart axis” and points to new avenues for dietary and microbial therapies.

28 Jul 2025

Vitamin D supplementation reduces liver inflammation and fibrosis largely through TXNIP

Chronic liver disease (CLD) is a major global health concern, affecting approximately 1.5 billion people. This life-threatening disease often progresses silently, eventually leading to worsened conditions like liver cirrhosis or liver cancer.

28 Jul 2025

Can one drug do it all? Reviewing the expanding clinical universe of GLP-1 agonists

Landmark trials have shown that GLP-1 receptor agonists, originally developed for diabetes and weight loss, also provide significant benefits for cardiovascular, kidney, liver, joint, and sleep-related diseases. These effects extend beyond weight loss, suggesting anti-inflammatory mechanisms with broad potential for managing chronic diseases.

22 Jul 2025

New 3D tissue model offers hope for scleroderma treatment

For the 300,000 Americans living with the immune disease scleroderma, better treatments can't come soon enough. The rare and sometimes fatal illness stiffens and scars tissue in organs like the lungs, liver, and kidneys, as well as skin.

22 Jul 2025

Global experts release guidance on CT imaging for post-COVID lung abnormalities

Experts representing multiple societies and institutions across 14 countries have published guidance for computed tomography (CT) imaging in patients with residual lung abnormalities after COVID-19 illness.

22 Jul 2025

Extreme childhood obesity drives liver and diabetes risks

Extreme obesity in US youth has risen significantly, linked to higher rates of diabetes and liver complications, necessitating immediate public health action.

22 Jul 2025

Muscle-derived vesicles heal damaged cells and reverse disease in new study

Researchers discovered that mitochondria-rich extracellular vesicles (Ti-mitoEVs) from skeletal muscle can deliver healthy mitochondria to damaged cells, restoring energy and promoting tissue repair in mice. The approach reversed acute muscle injury and chronic kidney disease, offering a promising new regenerative therapy.

21 Jul 2025

AI reshapes ARDS care by predicting risk, guiding ventilation, and personalizing treatment

Artificial intelligence and machine learning are transforming acute respiratory distress syndrome (ARDS) management, enabling earlier detection, precision risk stratification, and tailored therapies. Emerging AI techniques promise to improve outcomes, but real-world clinical validation and integration remain critical challenges.

21 Jul 2025

Heart scarring linked to abnormal rhythms in older male endurance athletes

Scar tissue in the heart was associated with abnormal heart rhythms among healthy, long-time male endurance athletes age 50 or older, potentially increasing their risk of sudden cardiac death, according to a small study published today in Circulation: Cardiovascular Imaging, an American Heart Association journal.

18 Jul 2025

Uncovering a protective RNA molecule in kidney stress and disease

Cells contain helper molecules called transfer RNAs (tRNAs), which carry building blocks (amino acids) to make proteins.

17 Jul 2025

Targeting GLUD1 shows promise in restoring muscle function in Duchenne muscular dystrophy

New research has identified the enzyme glutamate dehydrogenase 1 (GLUD1) as a new therapeutic target for Duchenne muscular dystrophy (DMD).

17 Jul 2025

Qureight analyze of Insilico Medicine's Phase IIa rentosertib data support preliminary efficacy results and future trial expansion

Qureight, a techbio company accelerating drug development using its proprietary deep-learning image biomarkers and clinical data analytics platform, today announced the first results from a collaboration with Insilico Medicine ("Insilico"), a clinical-stage biotechnology company driven by generative AI, focused on rentosertib (ISM001-055), a novel TNIK inhibitor discovered using Insilico's generative AI approach, in development for the treatment of IPF.

16 Jul 2025

New 3D bio-printed model closely mimics the complexity of natural lung tissue

UBC Okanagan researchers have developed a 3D bio-printed model that closely mimics the complexity of natural lung tissue, an innovation that could transform how scientists study lung disease and develop new treatments.

15 Jul 2025

Blocking Epac1 protein slows lung fibrosis in preclinical models

Researchers at the Icahn School of Medicine at Mount Sinai and collaborators have identified a previously overlooked protein, Epac1, as a key driver of idiopathic pulmonary fibrosis (IPF), a chronic and progressive lung-scarring disease.

15 Jul 2025

Early-career physician-scientists receive major support from Damon Runyon Cancer Research Foundation

The Damon Runyon Cancer Research Foundation has named five new Damon Runyon Clinical Investigators.

14 Jul 2025

Exploring the roles of orphan nuclear receptors in MASLD pathogenesis

Metabolic dysfunction-associated steatotic liver disease (MASLD), affecting approximately 30% of the global population, represents a spectrum of liver disorders ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis.

12 Jul 2025

Fibrosis News and Research

Further Reading

Canadian scientists trap gut microbe fuel to improve blood sugar and liver health

Exercise-based cardiac rehab benefits atrial fibrillation

NR2F1 drives fibrotic cataract formation through activation of STAT3

Siemens Healthineers sets new sustainability benchmark as first IVD manufacturer to earn My Green Lab ACT Ecolabel for analyzers, reagents

How a leaky gut could be putting your heart at risk

Vitamin D supplementation reduces liver inflammation and fibrosis largely through TXNIP

Can one drug do it all? Reviewing the expanding clinical universe of GLP-1 agonists

New 3D tissue model offers hope for scleroderma treatment

Global experts release guidance on CT imaging for post-COVID lung abnormalities

Extreme childhood obesity drives liver and diabetes risks

Muscle-derived vesicles heal damaged cells and reverse disease in new study

AI reshapes ARDS care by predicting risk, guiding ventilation, and personalizing treatment

Heart scarring linked to abnormal rhythms in older male endurance athletes

Uncovering a protective RNA molecule in kidney stress and disease

Targeting GLUD1 shows promise in restoring muscle function in Duchenne muscular dystrophy

Qureight analyze of Insilico Medicine's Phase IIa rentosertib data support preliminary efficacy results and future trial expansion

New 3D bio-printed model closely mimics the complexity of natural lung tissue

Blocking Epac1 protein slows lung fibrosis in preclinical models

Early-career physician-scientists receive major support from Damon Runyon Cancer Research Foundation

Exploring the roles of orphan nuclear receptors in MASLD pathogenesis

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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